Results 161 to 170 of about 7,951 (196)

Purinergic Regulation of Neutrophil Function

Frontiers in Immunology, 2018
Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through ...
Xu Wang
exaly   +3 more sources

Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells

Frontiers in Endocrinology, 2020
The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martín-aragón Baudel, Madeline Nieves-cintrón, Manuel F Navedo   +2 more
exaly   +3 more sources

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors [PDF]

Glia, 2012
AbstractMicroglia are sensitive to environmental changes and are immediately transformed into several phenotypes. For such dynamic “modal shifts”, purinergic receptors have central roles. When microglia sense ATP/ADP leaked from injured cells by P2Y12 receptors, they are transformed into a moving phenotype, showing process extension and migration ...
Kazuhide Inoue, Shinichi Kohsaka, Schuichi Koizumi, Keiko Ohsawa   +3 more
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P1 and P2 purinergic receptor signal transduction in rat type II pneumocytes

Journal of Applied Physiology, 1989
Extracellular ATP is a potent agonist of surfactant phosphatidylcholine (PC) exocytosis from type II pneumocytes in culture. We studied P1 and P2 receptor signal transduction in type II pneumocytes. The EC50 for ATP on PC exocytosis was 10(-6) M, whereas the EC50 for ADP, AMP, adenosine, and the nonmetabolizable ATP analogue alpha,beta-methylene ATP ...
L. Cosico, David Warburton, Sue Buckley
openaire   +3 more sources

Purinergic signaling: a common pathway for neural and mesenchymal stem cell maintenance and differentiation

Frontiers in Cellular Neuroscience, 2015
Extracellular ATP, related nucleotides and adenosine are among the earliest signaling molecules, operating in virtually all tissues and cells. Through their specific receptors, namely purinergic P1 for nucleosides and P2 for nucleotides, they are ...
Fabio Cavaliere, Nadia D'ambrosi
exaly   +3 more sources

P-/P-purinergic receptors on cultured rabbit retinal M�ller cells

Japanese Journal of Ophthalmology, 1998
Adenosine 5'-triphosphate (ATP) and its metabolic products function as neurotransmitters or neuromodulators under the control of P1/P2-purinergic receptors. To determine the presence of these receptors on retinal Müller cells, spectrofluorometry was carried out on intracellular calcium mobilization, using Fura-2 images.
Yao Liu, Masato Wakakura
openaire   +3 more sources

On the purinergic system in rat duodenum : existence of P₁and P₂receptors on the smooth muscle

Archives Internationales de Physiologie et de Biochimie, 1990
In rat duodenum, in vitro, in the presence of atropine and guanethidine, ATP administration caused a tetrodotoxin-insensitive relaxation followed by a rebound contraction. A similar response was obtained also after electrical field stimulation (EFS) of non-adrenergic, non-cholinergic (NANC) nerves.
Rosa Serio, A. Postorino, Flavia Mulè
openaire   +3 more sources

Genistein, an Inhibitor of Protein Tyrosine Kinase, Is Also a Competitive Antagonist for P1-Purinergic (Adenosine) Receptor in FRTL-5 Thyroid Cells

Biochemical and Biophysical Research Communications, 1994
Genistein, a potent inhibitor for protein tyrosine kinase, remarkably inhibited the stimulatory action of N6-(L-2-phenylisopropyl)adenosine (PIA), an A1-adenosine receptor agonist, on thyrotropin (TSH)-induced phospholipase C activation in FRTL-5 thyroid cells.
Yoichi Kondo, F Okajima, Hideaki Tomura, Kimie Sho, Mohammed Abdul Majid, Mohammed Akbar   +5 more
openaire   +3 more sources