Results 181 to 190 of about 22,494 (202)
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Purinergic receptors modulators: An emerging pharmacological tool for disease management
Medicinal research reviews (Print), 2022Purinergic signaling is mediated through extracellular nucleotides (adenosine 5′‐triphosphate, uridine‐5'‐triphosphate, adenosine diphosphate, uridine‐5'‐diphosphate, and adenosine) that serve as signaling molecules.
A. Mahmood, J. Iqbal
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P1 and P2 purinergic receptor signal transduction in rat type II pneumocytes
Journal of Applied Physiology, 1989Extracellular ATP is a potent agonist of surfactant phosphatidylcholine (PC) exocytosis from type II pneumocytes in culture. We studied P1 and P2 receptor signal transduction in type II pneumocytes. The EC50 for ATP on PC exocytosis was 10(-6) M, whereas the EC50 for ADP, AMP, adenosine, and the nonmetabolizable ATP analogue alpha,beta-methylene ATP ...
D, Warburton, S, Buckley, L, Cosico
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International Reviews of Immunology, 2020
The nucleotide adenosine-5′-triphosphate (ATP) is mostly thought to be energy carrier, but evidence presented in multiple studies proves ATP involvement into variety of processes, due to its neuromodulatory capabilities. ATP and its metabolite—adenosine,
Marharyta Zyma, R. Pawliczak
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The nucleotide adenosine-5′-triphosphate (ATP) is mostly thought to be energy carrier, but evidence presented in multiple studies proves ATP involvement into variety of processes, due to its neuromodulatory capabilities. ATP and its metabolite—adenosine,
Marharyta Zyma, R. Pawliczak
semanticscholar +1 more source
Mini-Reviews in Medical Chemistry, 2020
Recent studies have proven that the purinergic signaling pathway plays a key role in neurotransmission and neuromodulation, and is involved in various neurodegenerative diseases and psychiatric disorders.
Lili Pan +6 more
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Recent studies have proven that the purinergic signaling pathway plays a key role in neurotransmission and neuromodulation, and is involved in various neurodegenerative diseases and psychiatric disorders.
Lili Pan +6 more
semanticscholar +1 more source
Biochemical and Biophysical Research Communications, 1994
Genistein, a potent inhibitor for protein tyrosine kinase, remarkably inhibited the stimulatory action of N6-(L-2-phenylisopropyl)adenosine (PIA), an A1-adenosine receptor agonist, on thyrotropin (TSH)-induced phospholipase C activation in FRTL-5 thyroid cells.
F, Okajima +5 more
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Genistein, a potent inhibitor for protein tyrosine kinase, remarkably inhibited the stimulatory action of N6-(L-2-phenylisopropyl)adenosine (PIA), an A1-adenosine receptor agonist, on thyrotropin (TSH)-induced phospholipase C activation in FRTL-5 thyroid cells.
F, Okajima +5 more
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EPITHELIAL PURINERGIC RECEPTORS ARE DOWNREGULATED IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE
GastroenterologyPurines are among the most influential and ubiquitous signaling molecules. In the human body, there are 19 different purinergic receptor subtypes that are classified into P1 and P2 receptors.
Anna M. Tingler +2 more
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Nephrology, Dialysis and Transplantation
Indoxyl sulfate (IS) is a uremic toxin present in kidney diseases. It has hypertrophic effects on the heart, fibrotic effects on the kidney, and impairs the functioning of blood vessels through inflammatory processes.
Jeferson Stabile +4 more
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Indoxyl sulfate (IS) is a uremic toxin present in kidney diseases. It has hypertrophic effects on the heart, fibrotic effects on the kidney, and impairs the functioning of blood vessels through inflammatory processes.
Jeferson Stabile +4 more
semanticscholar +1 more source
Role of P1 and P2 purinergic receptors in the dentate gyrus during in vitro ischemia
2015The hippocampus is comprised of two distinct subfields that show different responses to hypoxic/ischemic brain injury: the CA1 region is particularly susceptible, whereas the dentate gyrus (DG) is quite resistant. A major resistance of the DG to ischemia in adulthood is probably due to the regenerative capacity of the neural stem cells of the ...
PUGLIESE, ANNA MARIA +7 more
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