Results 11 to 20 of about 8,520 (182)
The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease. [PDF]
J Trop MedChagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Pereira CSF, Faria RX.
europepmc +2 more sources
Purinergic signaling in the modulation of redox biology
Redox Biology, 2021 Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors ...
Luiz Eduardo Baggio Savio +4 more
doaj +1 more source
Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease
Frontiers in Neuroscience, 2021 Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich +4 more
doaj +1 more source
Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells
Frontiers in Endocrinology, 2020 The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martin-Aragon Baudel +3 more
doaj +1 more source
Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications
Molecular Imaging, 2020 Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes.
Hamideh Zarrinmayeh PhD +1 more
doaj +1 more source
Folia Neuropathologica, 2022 Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully ...
Lidia Babiec +2 more
doaj +1 more source
Purinergic Signaling and Related Biomarkers in Depression
Brain Sciences, 2020 It is established that purinergic signaling can shape a wide range of physiological functions, including neurotransmission and neuromodulation. The purinergic system may play a role in the pathophysiology of mood disorders, influencing neurotransmitter ...
Francesco Bartoli +3 more
doaj +1 more source
Purinergic signaling: A new front-line determinant of resistance and susceptibility in leishmaniasis
Biomedical Journal, 2022 Leishmaniasis is a neglected tropical disease that causes several clinical manifestations. Parasites of the genus Leishmania cause this disease. Spread across five continents, leishmaniasis is a particular public health problem in developing countries ...
Mariana Chaves +2 more
doaj +1 more source
Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]
, 2013 Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch +49 more
core +3 more sources
Purinergic Regulation of Neutrophil Function
Frontiers in Immunology, 2018 Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through ...
Xu Wang, Deyu Chen
doaj +1 more source