Results 11 to 20 of about 18,523 (160)

Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity

Frontiers in Pharmacology, 2018
Platelets are small anucleated cells present only in mammals. Platelets mediate intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in thrombosis.
Milka Koupenova, Katya Ravid
doaj   +2 more sources

Mitogenic signaling from P1 and P2 purinergic receptors to mitogen-activated protein kinase in human fetal astrocyte cultures

Neuroscience Letters, 1998
To investigate potential trophic actions of extracellular ATP in human astrocytes, we have examined mitogenic signaling by purinergic receptors in cultures prepared from first trimester rostral central nervous system tissue. We found that ATP and ATPgammaS, a hydrolysis-resistant analog, stimulated DNA synthesis, thereby indicating that P2 purinergic ...
J T, Neary, M, McCarthy, Y, Kang, S, Zuniga   +3 more
openaire   +3 more sources

Expression profiles of purinergic P1 and P2 receptors in cultured bovine aortic endothelial cells, bovine aortic smooth muscle cells, and human vascular endothelial EA.hy926 cells

The Journal of Toxicological Sciences
Purinergic signaling plays an important role in vascular biology by vascular tone, inflammation, and remodeling through extracellular nucleotides that activate the P1 and P2 receptors.
Lihito Ikeuchi, Takato Hara, Kazuki Kitabatake, Fumiaki Uchiumi, Chika Yamamoto, Mitsutoshi Tsukimoto, Tomoya Fujie, Toshiyuki Kaji   +7 more
openaire   +2 more sources

Uridine adenosine tetraphosphate (Up4A) as a novel coronary vasodilator in health and disease: Role of purinergic P1 and P2 receptors

The FASEB Journal, 2012
Up4A is a potent endothelium‐derived contracting factor that contains purine and pyrimidine moieties and activates purinergic P2X and P2Y receptors. Up4A has recently been found to also have vasodilator effects. Here, we evaluated Up4A in isolated coronary small arteries from normal (N) swine and swine after myocardial infarction ...
Zhichao Zhou, Dirk Jan Duncker, Daphne Merkus   +2 more
openaire   +2 more sources

Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery. [PDF]

Purinergic Signal
Hypochlorous acid (HOCl) is generated by neutrophils during the innate immune response. ATP is released from cells by various stimuli and during inflammation but whether ATP is released by and participates in the response to HOCl is unclear.
Baghdadi A, Dunn WR, Ralevic V.
europepmc   +2 more sources

Purinergic enzymes on extracellular vesicles: immune modulation on the go

Frontiers in Immunology
An increase in the extracellular concentration of ATP as a consequence of cellular stress or cell death results in the activation of immune cells. To prevent inflammation, extracellular ATP is rapidly metabolized to adenosine, which deploys an anti ...
Riekje Winzer, Du Hanh Nguyen, Felix Schoppmeier, Felix Schoppmeier, Filippo Cortesi, Filippo Cortesi, Nicola Gagliani, Nicola Gagliani, Eva Tolosa   +8 more
doaj   +2 more sources

Purines and purinergic receptors in primary tumors of the central nervous system. [PDF]

Purinergic Signal
Soares AA, Dos Santos HM, Domann KN, Alves NPR, Böhm BR, Haack CM, Pretto KP, Guimarães ES, Rocha GF, de Paula IR, de Alcântara Guimarães LE, de Ávila Pessoa HC, Rodrigues RD, Dalagnol AMK, da Cunha MLV, de Resende E Silva DT.   +15 more
europepmc   +2 more sources

Adenosine receptors as emerging therapeutic targets for diabetic kidney disease [PDF]

Kidney Research and Clinical Practice, 2022
Diabetic kidney disease (DKD) is now a pandemic worldwide, and novel therapeutic options are urgently required. Adenosine, an adenosine triphosphate metabolite, plays a role in kidney homeostasis through interacting with four types of adenosine receptors
Eun Seon Pak, Jin Joo Cha, Dae Ryong Cha, Keizo Kanasaki, Hunjoo Ha   +4 more
doaj   +1 more source

Purinergic signaling: Diverse effects and therapeutic potential in cancer

Frontiers in Oncology, 2023
Regardless of improved biological insights and therapeutic advances, cancer is consuming multiple lives worldwide. Cancer is a complex disease with diverse cellular, metabolic, and physiological parameters as its hallmarks.
Jasmeet Kaur, Sanchit Dora
doaj   +1 more source

The adenosinergic machinery in cancer: In-tandem insights from basic mechanisms to therapy

Frontiers in Immunology, 2023
Extracellular adenosine (eADO) signaling has emerged as an increasingly important regulator of immune responses, including tumor immunity. eADO is mainly produced from extracellular ATP (eATP) hydrolysis.
Chifei Kang, Chifei Kang, Luyu Liu, Chengyu Wu, Lingyun Li, Xiao Jia, Wendi Xie, Siyu Chen, Xinying Wu, Huaxiao Zheng, Jingxin Liu, Rongsong Li, Bin Zeng   +12 more
doaj   +1 more source