Results 51 to 60 of about 8,875 (174)
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.Abnormal extracellular ATP levels cause lower urinary tract symptoms (LUTS). Here, we demonstrate that overexpression of ENTPD1 (CD39TG)—an ATP/ADP converting enzyme—reduces voiding frequency while increasing void volume. Conversely, ENTPD1 deficiency results in frequent, small‐volume voiding.
Zhaobo Luo +7 more
wiley +1 more source
Characterisation of canine P2X and P2Y receptors
, 2021 Purinergic signalling is an important biological process that utilises extracellular nucleotides to activate P2X and P2Y purinergic receptors. P2 receptors play a range of roles in human physiology and pathophysiology. Despite this, little is known about
Reece Andrew Sophocleous (20166279)
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Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome
Arthritis &Rheumatology, Volume 78, Issue 4, Page 896-903, April 2026.Objective ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. The objective of this study was to evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired ...
Bruna de Moraes Mazetto Fonseca +13 more
wiley +1 more source
Pharmacological Separation of Mechanosensory Mechanisms in Rat Urinary Bladder Ex Vivo
Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.ABSTRACT The local response of the bladder wall to stretch is believed to result from the coordinated activation of mechanosensitive ion channels located in the plasma membrane of the cells that form the wall's urothelial and detrusor smooth muscle (DSM) layers.
Igor B. Philyppov +4 more
wiley +1 more source
Purinergic receptors in the endocrine and exocrine pancreas
, 2007 Udgivelsesdato: 2007-Dec-11The pancreas is a complex gland performing both endocrine and exocrine functions. In recent years there has been increasing evidence that both endocrine and exocrine cells possess purinergic receptors, which influence ...
Novak, I, I. Novak
core +1 more source
Advanced Science, Volume 13, Issue 18, 27 March 2026.This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan +10 more
wiley +1 more source
Purinergic receptors and the inflammatory response mediated by lipids.
, 2019 The inflammatory response is regulated by the production of different extracellular mediators, including lipids and extracellular nucleotides. In the extracellular environment, intermediate lipids activate specific G-protein-coupled receptors (GPCRs) in ...
Pelegrín, Pablo +2 more
core +1 more source
Purinergic receptors expressed in human skeletal muscle fibres
, 2011 Purinergic receptors are present in most tissues and thought to be involved in various signalling pathways, including neural signalling, cell metabolism and local regulation of the microcirculation in skeletal muscles. The present study aims to determine
A. Bornø +9 more
core +1 more source
, 1998 The P2Y₂ receptor is a uridine/adenosine triphosphate (UTP/ATP)-sensitive G-protein-linked nucleotide receptor that previously has been reported to stimulate the phosphoinositide signaling pathway.
Webb, TE +3 more
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The P2X receptor mediated regulation of inhibitory synaptic transmission [PDF]
In the central nervous system ATP can be released by neurons and glial cells through similar pathways as other neurotransmitters. Extracellular ATP targets P2X purinoreceptors, causing an influx of Ca2+ ions which transmit very important messages for ...
Andrew-Adiamah, Jemma
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