Results 61 to 70 of about 8,875 (174)

P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells [PDF]

, 2014
This work is supported the British Heart Foundation [grant number PG/13/22/ 30077]. Deposited in PMC for immediate release.The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and ...
Campwala, H., Fountain, Samuel J., Sexton, D. W., Campwala, Hinnah, Fountain, SJ, Crossman, David C., Sexton, Darren W., Campwala, H, Crossman, D. C., Fountain, S. J., Sexton, DW, Crossman, DC   +11 more
core   +1 more source

Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells: characterization and inhibition by low molecular weight antagonists

, 2009
P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus,
Gever, J.L.
core  

New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders

, 2007
Ionotropic P2X and metabotropic P2Y purinergic receptors are expressed in the central nervous system and participate in the synaptic process particularly associated with acetylcholine, GABA, and glutamate neurotransmission. As a result of activation, the
Trujillo, Cleber Augusto, Gomes, Katia das Neves, Katia N. Gomes, Cleber A. Trujillo, Henning Ulrich, Resende, Rodrigo Ribeiro, Lopes, Camila Galvão, Katia K. Yuahasi, Ulrich, Henning, Rodrigo R. Resende, Paromita Majumder, Luiz R. G. Britto, Majumder, Paromita, Camila G. Lopes, Britto, Luiz Roberto Giorgetti de, Yuahasi, Katia Kioko [UNIFESP]   +15 more
core   +1 more source

The Purinergic P2Y Receptor Family as Novel Drug Target in Epilepsy

, 2018
Epilepsy is one of the most common chronic neurological diseases and is characterized by recurrent seizures. Despite the existence of numerous anti-epileptic drugs, 30-40% of patients remain drug-refractory. Consequently, we must identify novel target genes with new mechanisms of action.
openaire   +1 more source

Expression of purinergic P2Y receptor subtypes by INS-1 insulinoma beta-cells: a molecular and binding characterization.

, 2007
National audiencePurinergic P2Y-receptor agonists amplify glucose-induced insulin secretion from pancreatic beta-cells, thus offering new opportunities for the treatment of type 2 diabetes.
Gross, René, Petit, Pierre, Vignon, Jacques, Lajoix, Anne-Dominique, Filhol, Romain, Lugo-Garcia, Laura   +5 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Nucleotides regulate NaCl transport in mIMCD-K2 cells via P2X and P2Y purinergic receptors

, 1999
Extracellular nucleotides regulate NaCl transport in some epithelia. However, the effects of nucleotide agonists on NaCl transport in the renal inner medullary collecting duct (IMCD) are not known.
Lisa M. Schwiebert, Bruce A. Stanton, Katherine Karlson, Erik M. Schwiebert, Amanda L. Taylor, Brian A. Kudlow, David E. McCoy, Margaret J. Slattery   +7 more
core   +1 more source

Role of P2Y purinergic receptors in neuron-glia signaling in trigeminal ganglia: involvement in pain transmission

, 2010
During chronic pain conditions, a cross-communication between sensory neurons and satellite glial cells (SGCs) within the trigeminal ganglia (TG), contributes to the development of hyperalgesia and allodynia.
L. Jasmin, M. Fumagalli, C. Verderio, A. M. van den Maagdenberg, M.P. Abbracchio, S.M. Ceruti, A. Bhargava, L. Colombo, P. T. Ohara, M. Zanardelli, G. Villa   +10 more
core  

Characteristics of the P2Y 11 nucleotide receptor : ligand binding characteristics and P2Y 11-P2Y 1 receptor [PDF]

, 2007
Purinergic receptors, nucleotides, P2Y, diastereoselectivity, potency, mutagenesis, ligand recognition, heterooligomerization, endocytosis, co-pulldownMagdeburg, Univ., Fak.
Ecke, Denise
core  

Role of P2Y receptors in trigeminal pain signalling

, 2008
Migraine is a chronic neurovascular disorder associated to activation and sensitization of the trigeminovascular system. Since little information is available on purinergic transmission in the generation of migraine pain, we aimed at studying the ...
M. Fumagalli, C. Verderio, S. Ceruti, M.P. Abbracchio, G. Villa   +4 more
core   +1 more source