Results 151 to 160 of about 550,877 (189)
Developmental synchrony of retinal waves, apoptosis, and angiogenesis in postnatal retina. [PDF]
ElifeSavage MA +7 more
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P2Y12 Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment [PDF]
Molecules, 2021 Gliomas are the most common malignant brain tumors in adults, characterized by a high proliferation and invasion. The tumor microenvironment is rich in growth-promoting signals and immunomodulatory pathways, which increase the tumor’s aggressiveness. In response to hypoxia and glioma therapy, the amounts of adenosine triphosphate (ATP) and adenosine ...
Liliana Rockenbach +2 more
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International Journal of Biological Sciences, 2023 Increasing evidence suggests that immunometabolism has started to unveil the role of metabolism in shaping immune function and autoimmune diseases. In this study, our data show that purinergic receptor P2Y12 (P2RY12) is highly expressed in concanavalin A (ConA)-induced immune hepatitis mouse model and serves as a potential metabolic regulator in ...
Changsheng Du, Changjie Shi
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Molecular modeling of purinergic receptor P2Y12 and interaction with its antagonists
Journal of Molecular Graphics and Modelling, 2007Purinergic receptors are a class of cell surface receptors for purines that prefer ATP or ADP over adenosine. The surface receptors for extracellular nucleotides are called P2 receptors. They are activated by both pyrimidine and purine nucleotides. ADP initiates platelet aggregation by 'simultaneous activation of two G protein-coupled receptors, P2Y1 ...
Chenyang Zhan
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Expression and Localization of Purinergic P2Y12 Receptor in Human Nasal Mucosa
Allergology International, 2013 Extracellular nucleotides such as ATP and UTP are released from essentially all cells, and they interact with cell surface P2 receptors to produce a broad range of physiological responses. P2Y12 receptor is the major platelet receptor that mediates ADP-induced aggregation, P2Y12 receptor inhibitors such as clopidogrel and prasugrel inhibit platelet ...
Hideaki Shirasaki +2 more
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Thrombosis and Haemostasis, 2015
SummaryP2Y12 receptor is required for sustained activation of integrin αllbβ3, irreversible platelet aggregation and thrombus stabilisation. Tetraspanin superfamily member CD151 associates with integrin aNbp3 and plays critical roles in regulation of thrombus growth and stability in vivo.
Denise E Jackson +2 more
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SummaryP2Y12 receptor is required for sustained activation of integrin αllbβ3, irreversible platelet aggregation and thrombus stabilisation. Tetraspanin superfamily member CD151 associates with integrin aNbp3 and plays critical roles in regulation of thrombus growth and stability in vivo.
Denise E Jackson +2 more
exaly +3 more sources
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is associated with protein misfolding, plaque accumulation, neuronal dysfunction, synaptic loss, and cognitive decline. The pathological cascade of AD includes the intracellular Tau hyperphosphorylation and its subsequent aggregation, extracellular Amyloid-β plaque formation and ...
Subashchandrabose, Chinnathambi +2 more
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Alzheimer's disease (AD) is a progressive neurodegenerative disease that is associated with protein misfolding, plaque accumulation, neuronal dysfunction, synaptic loss, and cognitive decline. The pathological cascade of AD includes the intracellular Tau hyperphosphorylation and its subsequent aggregation, extracellular Amyloid-β plaque formation and ...
Subashchandrabose, Chinnathambi +2 more
openaire +2 more sources
Thrombosis and Haemostasis, 2010
SummaryToll-like receptor 2 (TLR2), which recognise and respond to conserved microbial pathogen-associated molecular patterns, is expressed on the platelet surface. Furthermore, it has recently been shown that the TLR2/1 agonist Pam3CSK4 stimulates platelet activation.
Maria Lerm +2 more
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SummaryToll-like receptor 2 (TLR2), which recognise and respond to conserved microbial pathogen-associated molecular patterns, is expressed on the platelet surface. Furthermore, it has recently been shown that the TLR2/1 agonist Pam3CSK4 stimulates platelet activation.
Maria Lerm +2 more
exaly +3 more sources
A Comparison of Microglia Detection in Mammals and Humans Using Purinergic Receptor P2Y12 Labeling
Journal of Evolutionary Biochemistry and Physiology, 2021The problem of choosing an adequate method to detect microglia is relevant for modern neurophysiological and interdisciplinary research due to the lack of universal approaches allowing visualization of this cell population in the brain of humans and laboratory animals.
D. E. Korzhevskii +3 more
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Purinergic Signalling, 2020 ATP is a cotransmitter released with other neurotransmitters from sympathetic nerves, where it stimulates purinergic receptors. Purinergic adenosine P1 receptors (coupled to Gi/o proteins) produce sympatho-inhibition in several autonomic effectors by prejunctional inhibition of neurotransmitter release.
Kristian A Haanes +2 more
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