Results 171 to 180 of about 550,877 (189)

Toll like receptor 2/1 mediated platelet adhesion and activation on bacterial mimetic surfaces is dependent on src/Syk-signaling and purinergic receptor P2X1 and P2Y12 activation

Biointerphases, 2014
Platelets are considered to have important functions in inflammatory processes as key players in innate immunity. Toll like receptors (TLRs), expressed on platelets, recognize pathogen associated molecular patterns and trigger immune responses. Pathogens are able to adhere to human tissues and form biofilms which cause a continuous activation of the ...
Kristin, Klarström Engström, Caroline, Brommesson, Hanna, Kälvegren, Torbjörn, Bengtsson   +3 more
openaire   +2 more sources

Carba‐nucleosides as Potent Antagonists of the Adenosine 5′‐Diphosphate (ADP) Purinergic Receptor (P2Y₁₂) on Human Platelets

ChemMedChem, 2008
Whereas the activation and aggregation of blood platelets are crucial to normal hemostasis, this ensemble is also a key factor in serious cardiovascular disorders, such as myocardial infarction, unstable angina, transient ischemic attack, stroke, peripheral arterial disease, and artherosclerosis.
Hong, Ye, Cailin, Chen, Han-Cheng, Zhang, Barbara, Haertlein, Tom J, Parry, Bruce P, Damiano, Bruce E, Maryanoff   +6 more
openaire   +2 more sources

Restored response to ADP downstream of purinergic P2Y₁₂ receptor in apheresis platelets after pathogen‐reducing xenon flash treatment

Transfusion, 2018
BACKGROUNDOur previous study revealed that pathogen‐reducing filtered xenon flash‐treated platelets (fXe‐PLTs) showed sustained aggregation in response to adenosine diphosphate (ADP), but apheresis‐collected PLTs (Aph‐PLTs) showed reversible aggregation.STUDY DESIGN AND METHODSAph‐PLTs, fXe‐PLTs, and freshly prepared PLTs (PRP‐PLTs) from whole blood ...
Hideki, Abe, Takaaki, Abe, Masayuki, Shiba, Masahiro, Satake   +3 more
openaire   +2 more sources

Interaction of Tau with G-Protein-Coupled Purinergic P2Y12 Receptor by Molecular Docking and Molecular Dynamic Simulation

Alzheimer's disease, a progressive neurological disorder, is characterized by the accumulation of neurofibrillary tangles and senile plaques by Tau and amyloid-β, respectively, in the brain microenvironment. The misfolded protein aggregates interact with several components of neuronal and glial cells such as membrane lipids, receptors, transporters ...
Hariharakrishnan Chidambaram, Smita Eknath Desale, Subashchandrabose Chinnathambi   +2 more
openaire   +2 more sources

Carba-nucleosides as Potent Antagonists of the Adenosine 5′-Diphosphate (ADP) Purinergic Receptor (P2Y12) on Human Platelets

ChemMedChem, 2008
Han-Cheng Zhang, Bruce P Damiano, Cailin Chen   +2 more
exaly  

Human Pancreatic Islets Express the Purinergic P2Y₁₁and P2Y₁₂Receptors

Hormone and Metabolic Research, 2008
L, Lugo-Garcia, B, Nadal, R, Gomis, P, Petit, R, Gross, A D, Lajoix   +5 more
openaire   +2 more sources

Association Between Polymorphisms in the Purinergic P2Y12 Receptor Gene and Severity of Both Cancer Pain and Postoperative Pain

Pain Medicine, 2018
Kazutaka Ikeda, Hiroaki Abe, Masahiko Sumitani   +2 more
exaly  

Evidence that the purinergic receptor P2Y12 potentiates platelet shape change by a Rho kinase-dependent mechanism

Platelets, 2005
Alastair W Poole, Darryl J Hill
exaly  

ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1

Acta Pharmacologica Sinica, 2020
Qing Jing, Xiao-Shuai Han
exaly  

Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma

Clinical and Experimental Allergy, 2012
Supinda Bunyavanich, S T Weiss
exaly