Results 161 to 170 of about 550,877 (189)

P2Y12 but not P2Y13 Purinergic Receptor Controls Postnatal Rat Retinogenesis In Vivo

Molecular Neurobiology, 2018
Adenine nucleotides through P2Y1 receptor stimulation are known to control retinal progenitor cell (RPC) proliferation by modulating expression of the p57KIP2, a cell cycle regulator. However, the role of Gi protein-coupled P2Y12 and P2Y13 receptors also activated by adenine nucleotides in RPC proliferation is still unknown.
Luana de Almeida-Pereira, Marinna Garcia Repossi, Camila Feitosa Magalhães, Rafael de Freitas Azevedo, Juliana da Cruz Corrêa-Velloso, Henning Ulrich, Ana Lúcia Marques Ventura, Lucianne Fragel-Madeira   +7 more
openaire   +2 more sources

A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor

Bioorganic & Medicinal Chemistry Letters, 2011
A novel series of P2Y(12) antagonists for development of drugs within the antiplatelet area is presented. The synthesis of the piperazinyl-pyridine urea derivatives and their structure-activity relationships (SAR) are described. Several compounds showed P2Y(12) antagonistic activities in the sub-micromolar range.
Peter, Bach, Jonas, Boström, Kay, Brickmann, J J J, van Giezen, Ragnar, Hovland, Annika U, Petersson, Asim, Ray, Fredrik, Zetterberg   +7 more
openaire   +2 more sources

ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12 [PDF]

Cell Death and Disease, 2019
AbstractMelanoma immunotherapy is still not satisfactory due to immunosuppressive cell populations within the tumor stroma. Targeting tumor-associated macrophages (TAM) can help to restore an anti-tumor immunity. Previously, we could show that classical TAM markers expressed in vivo need a 7 day M-CSF/dexamethasone/IL-4 (MDI) stimulation for their ...
Jochen Utikal, Carolina de la Torre, Kai Schledzewski   +2 more
exaly   +3 more sources

A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y12 receptor in platelets

Thrombosis Research, 2018
Tumor-suppressing subchromosomal transferable fragment cDNA 6 (TSSC6) expression is restricted to hematopoietic organs and tissues where it plays a role in hematopoietic-cell function. The ADP purinergic receptor P2Y12 is mainly expressed by platelets with important clinical significance as a target for several clinically approved antithrombotic agents.
Denise E Jackson, Mark D Wright, David Howells   +2 more
exaly   +3 more sources

Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin [PDF]

Journal of Biological Chemistry, 2017
Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated receptor-4 (PAR4) has been shown to dimerize with the ...
Michael R Dores, Thomas H Smith, JoAnn Trejo   +2 more
exaly   +5 more sources

The role of purinergic P2Y12 receptor blockers on the angiogenic properties of endothelial cells: an in vitro study.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2018
Pharmacotherapy with agents that inhibit platelet function has proven to be effective in the treatment of acute coronary syndrome. Proper re-endothelization after angioplasty prevents adverse cardiovascular events. Therefore, in this in vitro study we examined how antiplatelet P2Y12 receptor blockers can affect endothelial cells' angiogenic properties.
K, Korybalska, R, Rutkowski, J, Luczak, N, Czepulis, K, Karpinski, J, Witowski   +5 more
openaire   +2 more sources

Purinergic P2Y12 Receptor Blockade Inhibits Shear-Induced Platelet Phosphatidylinositol 3-Kinase Activation

Molecular Pharmacology, 2003
Pathologically elevated shear stress triggers aspirin-insensitive platelet thrombosis. Signaling mechanisms involved in shear-induced platelet thrombosis are not well understood. To investigate these, we examined the hypothesis that functionally important platelet phosphatidylinositol 3-kinase (PI3-K) activity is stimulated by an in vitro shear stress ...
Julio C, Reséndiz, Shuju, Feng, Guilan, Ji, Ketia A, Francis, Michael C, Berndt, Michael H, Kroll   +5 more
openaire   +2 more sources

Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia

Microglia are the resident brain macrophage cells that are involved in constant surveillance of brain microenvironment. In Alzheimer's disease, microglia get over activated upon the accumulation of Tau and amyloid-β species in the extracellular space, ultimately leading to neurodegeneration.
Hariharakrishnan Chidambaram, Smita Eknath Desale, Subashchandrabose Chinnathambi   +2 more
openaire   +2 more sources

Functional characterization of purinergic P2Y2 and P2Y12 receptors involved in Japanese flounder (Paralichthys olivaceus) innate immune responses

Fish & Shellfish Immunology, 2018
G-protein-coupled P2Y receptors activated by extracellular nucleotides play important roles under different physiological and pathophysiological conditions in mammals. To investigate the immunological relevance of P2Y receptors in fish, we identified and characterized the P2Y2 and P2Y12 receptors in Japanese flounder Paralichthys olivaceus.
Shuo, Li, Gaixiang, Hao, Yaqi, Xu, Nan, Wang, Jiafang, Li, Xuyun, Geng, Jinsheng, Sun   +6 more
openaire   +2 more sources

The role of the purinergic receptor P2Y12 in Alzheimer's disease

Alzheimer’s disease (AD), the most common cause of dementia, shows a significant rise in prevalence due to increased global life expectancy and represents a major public health, social, and economic burden. Microglia, the resident immune cells of the CNS, have recently moved into prime focus of AD research due to the discovery of risk loci and genes ...
openaire   +1 more source