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Scavenger Receptors and Atherosclerosis

Biological Research, 2000
Scavenger receptors were discovered as cell surface proteins capable of binding and internalization of modified lipoproteins. These receptors exhibit a broad ligand binding specificity including potential physiological and pathophysiological ligands ...
ATTILIO RIGOTTI
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Scavenger receptors: key players in the immunological puzzle of lupus [PDF]

Frontiers in Lupus
Scavenger receptors (SRs) play an important role in the innate immune response by recognizing and binding a variety of ligands to initiate the removal of both altered self- and non-self-antigens. Over the last two decades, SRs have become a forefront for
Sabine Hahn, Monika Chitre, Dominique Shepard, Romana Rashid, Zaida G. Ramirez-Ortiz   +4 more
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The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors [PDF]

Frontiers in Immunology, 2015
The class A Scavenger Receptor (cA-SR) family is a group of five evolutionarily related innate immune receptors. The cA-SRs are known for their promiscuous ligand binding; as they have been shown to bind bacteria such as Streptococcus pneumoniae, and ...
Nicholas eYap, Fiona Jane Whelan, Dawn M.E. Bowdish, Brian eGolding   +3 more
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Scavenger receptors [PDF]

Current Biology, 2020
Scavenger receptors (SRs) are a large family of cell-surface receptors that are diverse in their structure and biological function and are divided into different classes. SRs can bind to a range of ligands and enhance the elimination of altered-self or non-self targets.
Ali, Alquraini, Joseph, El Khoury
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Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer

Frontiers in Oncology, 2021
Alpha-fetoprotein (AFP) entrance into cancer cells is mediated by AFP receptors (AFPRs) and exerts malignant effects. Therefore, understanding the structure of AFPRs will facilitate the development of rational approaches for vaccine design, drug delivery,
Bo Lin, Qiujiao Wang, Kun Liu, Xu Dong, Mingyue Zhu, Mengsen Li, Mengsen Li   +6 more
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Standardizing Scavenger Receptor Nomenclature [PDF]

The Journal of Immunology, 2014
Abstract Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a variety of ligands, including endogenous and modified host-derived molecules and microbial pathogens.
PrabhuDas, Mercy, Bowdish, Dawn, Drickamer, Kurt, Febbraio, Maria, Herz, Joachim, Kobzik, Lester, Krieger, Monty, Loike, John D., Means, Terry K., Moestrup, Soren K., Post, Steven, Sawamura, Tatsuya, Silverstein, Samuel C., Wang, Xiang-Yang, El Khoury, Joseph   +14 more
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Scavenger receptors in host defense: from functional aspects to mode of action

Cell Communication and Signaling, 2022
Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous and encompass the miscellaneous group of transmembrane proteins and soluble secretory extracellular domain.
Qamar Taban, Peerzada Tajamul Mumtaz, Khalid Z. Masoodi, Ehtishamul Haq, Syed Mudasir Ahmad   +4 more
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Macrophage scavenger receptors: Tumor support and tumor inhibition

Frontiers in Oncology, 2023
Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells that constitute up to 50% of the cell mass of human tumors. TAMs interact with the components of the tumor microenvironment (TME) by using scavenger receptors (SRs), a ...
Elena Kazakova, Elena Kazakova, Pavel Iamshchikov, Pavel Iamshchikov, Irina Larionova, Irina Larionova, Irina Larionova, Julia Kzhyshkowska, Julia Kzhyshkowska, Julia Kzhyshkowska, Julia Kzhyshkowska   +10 more
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Thematic review series: The Immune System and Atherogenesis. Recent insights into the biology of macrophage scavenger receptors

Journal of Lipid Research, 2005
Scavenger receptors were originally defined by their ability to bind and internalize modified lipoproteins. Macrophages express at least six structurally different cell surface receptors for modified forms of LDL that contribute to foam cell formation in
David R. Greaves, Siamon Gordon
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Targeting Scavenger Receptors in Inflammatory Disorders and Oxidative Stress

Antioxidants, 2022
Oxidative stress and inflammation cannot be considered as diseases themselves; however, they are major risk factors for the development and progression of the pathogenesis underlying many illnesses, such as cancer, neurological disorders (including ...
Govigerel Bayarsaikhan, Delger Bayarsaikhan, Jaewon Lee, Bonghee Lee   +3 more
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