Results 51 to 60 of about 54,333 (259)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Nitrosylated high density lipoprotein is recognized by a scavenger receptor in rat liver.

Journal of Lipid Research, 1989
In order to assess the presence of specific recognition sites for high density lipoprotein (HDL) in vivo, HDL was nitrosylated with tetranitromethane and the decay and liver uptake were compared with that of native HDL.
M F Kleinherenbrink-Stins, D Schouten, J van der Boom, A Brouwer, D L Knook, T J van Berkel   +5 more
doaj   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface

Journal of Lipid Research, 1999
In addition to its effect on high density lipoprotein (HDL) cholesteryl ester (CE) uptake, scavenger receptor BI (SR-BI) was recently reported to stimulate free cholesterol (FC) flux from Chinese hamster ovary (CHO) cells stably expressing mouse SR-BI, a
Margarita de la Llera-Moya, George H. Rothblat, Margery A. Connelly, Ginny Kellner-Weibel, Sana W. Sakr, Michael C. Phillips, David L. Williams   +6 more
doaj   +1 more source

Homeostasis: A scavenger receptor for haemoglobin [PDF]

Current Biology, 2001
Recent studies have identified a macrophage-specific receptor for the clearance of haemoglobin-haptoglobin complexes, which protects the host against the toxicity of free haemoglobin.
openaire   +2 more sources

Three‐Dimensional Biomimetic Aerogel Conduits with Electro‐Ionic‐Immune Coupling Reverse the Pathological Cascade of Spinal Cord Injury

Advanced Functional Materials, EarlyView.
A biomimetic aerogel conduit was engineered from a nanofiber of gelatin/poly(l‐lactic acid) doped with polypyrrole nanoparticles, integrated with tannic acid and Mg2+. This “electro‐ionic‐immune” strategy mimicked spinal cord properties, reduced calcium overload, inflammation, oxidative damage, promoted neural stem cell differentiation, suppressed ...
Qingxiang Liu, Xin Yu, Jingtong Li, Chunyang Zheng, Yukang Zhang, Mingyu Jia, Tan Tian, Weiwei Zheng, Pinghui Zhou, Yingji Mao   +9 more
wiley   +1 more source

Polymorphism of class A scavenger receptors in C57BL/6 mice1

Journal of Lipid Research, 2000
Scavenger receptors class A (SR-A) have been hypothesized to regulate the development of atherosclerotic lesions through recognition of modified low density lipoprotein (LDL) and macrophage adhesion to substrata.
Alan Daugherty, Stewart C. Whitman, Amy E. Block, Debra L. Rateri   +3 more
doaj   +1 more source

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides

Nature Communications, 2020
Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating ...
Max Meyrath, Martyna Szpakowska, Julian Zeiner, Laurent Massotte, Myriam P. Merz, Tobias Benkel, Katharina Simon, Jochen Ohnmacht, Jonathan D. Turner, Rejko Krüger, Vincent Seutin, Markus Ollert, Evi Kostenis, Andy Chevigné   +13 more
doaj   +1 more source

Mimicking Silent Synapse Recruitment: A SiOx/Cu‐Pancake Memristive Device For Analog Neuromorphic Computing

Advanced Functional Materials, EarlyView.
Electroforming‐free TiN/SiOx/Cu/SiOx/TiN memristive devices exploit pancake‐like Cu nanoparticles embedded in a SiOx double layer to create a heterogeneous Schottky‐barrier landscape. Under bias, oxygen‐vacancy redistribution progressively lowers local barriers and recruits initially inactive Cu‐PC pathways into a parallel conduction ensemble, enabling
Rouven Lamprecht, Ole Gronenberg, Sahitya Yarragolla, Tobias Gergs, Richard Marquardt, Victor Witte, Jürgen Carstensen, George Popkirov, Jan Trieschmann, Lorenz Kienle, Hermann Kohlstedt   +10 more
wiley   +1 more source