Results 51 to 60 of about 56,954 (204)

Pituitary somatostatin receptor signaling [PDF]

Trends in Endocrinology & Metabolism, 2010
Somatotropin-release inhibitory factor (SRIF) is a major regulator of pituitary function, mostly inhibiting hormone secretion and to a lesser extent pituitary cell growth. Five SRIF receptor subtypes (SSTR1-5) are ubiquitously expressed G-protein coupled receptors.
Anat, Ben-Shlomo, Shlomo, Melmed
openaire   +2 more sources

A computational study of somatostatin subtype-4 receptor agonist binding

SN Applied Sciences, 2022
The somatostatin subtype-4 receptor (sst4) is highly expressed in neocortical and hippocampal areas, which are affected by amyloid beta accumulation. Sst4 agonists enhance downstream activity of amyloid beta peptide catabolism through neprilysin and may ...
Olivia Slater, Maria Kontoyianni
doaj   +1 more source

Bidirectional plasticity of GABAergic tonic inhibition in hippocampal somatostatin- and parvalbumin-containing interneurons

Frontiers in Cellular Neuroscience, 2023
GABAA receptors present in extrasynaptic areas mediate tonic inhibition in hippocampal neurons regulating the performance of neural networks. In this study, we investigated the effect of NMDA-induced plasticity on tonic inhibition in somatostatin- and ...
Marcin Wyroślak, Grzegorz Dobrzański, Jerzy W. Mozrzymas   +2 more
doaj   +1 more source

Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence

Frontiers in Behavioral Neuroscience, 2019
Somatostatin (SOM) and somatostatin receptors (SSTR1–4) are present in all olfactory structures, including the olfactory bulb (OB), where SOM modulates physiological gamma rhythms and olfactory discrimination responses.
Sonia Nocera, Sonia Nocera, Axelle Simon, Axelle Simon, Oriane Fiquet, Oriane Fiquet, Ying Chen, Ying Chen, Jean Gascuel, Frédérique Datiche, Nanette Schneider, Jacques Epelbaum, Jacques Epelbaum, Cécile Viollet, Cécile Viollet   +14 more
doaj   +1 more source

Two Birds with One Stone: Skull Base Meningioma and Jugulotympanic Paragangliomas with Somatostatin Receptor Positron Emission Tomography

Diagnostics, 2021
We describe the case of a 74-year-old female patient previously treated with radiation therapy for a meningioma of the skull base and with surgery for a right tympanic paraganglioma.
Giorgio Treglia, Mariana Raditchkova, Luca Giovanella, Jean-Jacques Stelmes, Davide G. Bosetti, Francesco Martucci   +5 more
doaj   +1 more source

Agonists, Antagonists and Receptors of Somatostatin: Pathophysiological and Therapeutical Implications in Neoplasias

Current Issues in Molecular Biology
Somatostatin is a peptide that plays a variety of roles such as neurotransmitter and endocrine regulator; its actions as a cell regulator in various tissues of the human body are represented mainly by inhibitory effects, and it shows potent activity ...
Argyrios Periferakis, Georgios Tsigas, Aristodemos-Theodoros Periferakis, Carla Mihaela Tone, Daria Alexandra Hemes, Konstantinos Periferakis, Lamprini Troumpata, Ioana Anca Badarau, Cristian Scheau, Ana Caruntu, Ilinca Savulescu-Fiedler, Constantin Caruntu, Andreea-Elena Scheau   +12 more
doaj   +1 more source

Somatostatin and opioid receptors do not regulate proliferation or apoptosis of the human multiple myeloma U266 cells

Journal of Experimental & Clinical Cancer Research, 2009
Background opioid and somatostatin receptors (SSTRs) that can assemble as heterodimer were individually reported to modulate malignant cell proliferation and to favour apoptosis.
Allouche Stéphane, Jauzac Philippe, Sola Brigitte, Cavey Thibault, Kerros Céline   +4 more
doaj   +1 more source

Focal Spot, Fall/Winter 1993 [PDF]

, 1993
https://digitalcommons.wustl.edu/focal_spot_archives/1065/thumbnail ...

core   +1 more source

On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]

, 2013
The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Fuxe, Kjell, Rivera, Alicia, Romero-Fernandez, Wilber, Tarakanov, Alexander O, Van Craenenbroeck, Kathleen   +6 more
core   +3 more sources

68Ga-DOTATATE Uptake in COVID-19 Pneumonia: A Non-Neoplastic False Positive

World Journal of Nuclear Medicine, 2022
In the detection and characterization of neuroendocrine tumors (NETs), the NETSPOT 68Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) utilizes a somatostatin analog to capture whole body imaging of somatostatin receptors.
Joshua P. Weissman, Twyla Bartel
doaj   +1 more source