In Silico Identification of Molecular Interactions of the Emerging Contaminant Octyl Methoxycinnamate (OMC) on HPT Axis: Implications for Humans and Zebrafish [PDF]
PharmaceuticalsBackground/Objectives: Thyroid hormones (THs) regulate almost all physiological processes in vertebrates via specific mechanisms exercised spatiotemporally throughout the lifespan.
Margarida Lorigo +5 more
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Desensitization, trafficking and resensitization of the pituitary thyrotropin-releasing hormone receptor [PDF]
Frontiers in Neuroscience, 2012 The pituitary receptor for thyrotropin-releasing hormone (TRH) is a calcium-mobilizing G protein-coupled receptor (GPCR) that signals through Gq/11, elevating calcium and activating protein kinase C.
Patricia M Hinkle +2 more
doaj +3 more sources
Characterization of a novel thyrotropin-releasing hormone receptor, TRHR3, in chickens
Poultry Science, 2020 The physiological roles of thyrotropin-releasing hormone (TRH) are proposed to be mediated by TRH receptors (TRHR), which have been divided into 3 subtypes, namely, TRHR1, TRHR2, and TRHR3, in vertebrates.
Xiaoxiao Li +5 more
doaj +3 more sources
Role of the thyrotropin-releasing hormone of the limbic system in mood and eating regulation
Journal of Integrative Neuroscience, 2022 Thyrotropin-releasing hormone (TRH) and its receptors are expressed in the hypothalamus and limbic regions. Brain thyrotropin-releasing hormone actions are exerted directly through its receptors and indirectly by modulating the effects of ...
Elena Alvarez-Salas +3 more
doaj +1 more source
Receptor modulators associated with the hypothalamus -pituitary-thyroid axis
Frontiers in Pharmacology, 2023 The hypothalamus-pituitary-thyroid (HPT) axis maintains normal metabolic balance and homeostasis in the human body through positive and negative feedback regulation.
Xianbin Cheng +7 more
doaj +1 more source
Biochemical and physiological insights into TRH receptor-mediated signaling
Frontiers in Cell and Developmental Biology, 2022 Thyrotropin-releasing hormone (TRH) is an important endocrine agent that regulates the function of cells in the anterior pituitary and the central and peripheral nervous systems.
Radka Trubacova +2 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2023 Benzisothiazolinone (BIT), one of the most widely used antimicrobial agents in consumer products, has frequently been detected in the water environment. The present study was conducted to determine the adverse effects of BIT on the thyroid neuroendocrine
Sujin Lee +4 more
doaj +1 more source
Interaction between the hypothalamo-pituitary-adrenal and thyroid axes during immobilization stress
Frontiers in Physiology, 2022 The location of corticotropin-releasing hormone receptor 2 (CRH-R2) on thyrotropes within the avian anterior pituitary (APit) and its activation by different stressors indicate a possible communication between hypothalamo-pituitary-adrenal (HPA) and ...
Hakeem J. Kadhim, Wayne J. Kuenzel
doaj +1 more source
Thyrotropin-releasing hormone receptors -- similarities and differences [PDF]
Journal of Molecular Endocrinology, 2003 Thyrotropin-releasing hormone (TRH) initiates its effects by interacting with cell-surface membrane receptors. Two G protein-coupled receptors for TRH, TRH receptor type 1 (TRH-R1) and TRH receptor type 2 (TRH-R2), have been cloned from mammals. In this review, we compare TRH-R1 and TRH-R2 with regard to their tIssue distribution, binding affinities ...
Y, Sun, X, Lu, M C, Gershengorn
openaire +2 more sources
Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter. [PDF]
PLoS ONE, 2010 Hormonally-regulated histone modifications that govern positive versus negative transcription of target genes are poorly characterized despite their importance for normal and pathological endocrine function.
Dongqing Wang +4 more
doaj +1 more source