Results 41 to 50 of about 13,430 (194)

Gastrointestinal neurotensin receptors: lack of modulation by thyrotropin releasing hormone

Journal of Pharmacy and Pharmacology, 1985
AbstractTo examine whether thyrotropin releasing hormone (TRH) antagonized gastrointestinal neurotensin receptors in isolated segments of the rat fundus, duodenum and ileum, tissues were superfused, mounted and the isometric tension recorded. Picomoles of neurotensin caused concentration-dependent contractions of the fundus and relaxation of the smooth
M V, Donoso, J P, Huidobro-Toro
openaire   +2 more sources

Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning

Frontiers in Cellular Neuroscience, 2018
Thyrotropin-releasing hormone (TRH) regulates various physiological activities through activation of receptors expressed in a broad range of cells in the central nervous system.
Masashi Watanave, Yasunori Matsuzaki, Yasuyo Nakajima, Atsushi Ozawa, Masanobu Yamada, Hirokazu Hirai, Hirokazu Hirai   +6 more
doaj   +1 more source

Thyrotropin-Releasing Hormone Receptor Processing: Role of Ubiquitination and Proteasomal Degradation [PDF]

Molecular Endocrinology, 2003
These studies were designed to characterize ubiquitination of the G protein-coupled TRH receptor (TRHR). TRHRs and ubiquitin coprecipitated with antibodies to either receptor or ubiquitin in Chinese hamster ovary or pituitary GHFT cells. Inhibition of the proteasome with MG-132 resulted in an accumulation of total TRHRs and the appearance of a small ...
Laurie B, Cook, Chang-Cheng, Zhu, Patricia M, Hinkle   +2 more
openaire   +2 more sources

Neural differentiation of the human neuroblastoma cell line IMR32 induces production of a thyrotropin-releasing hormone-like peptide [PDF]

, 1994
The human neuroblastoma cell line IMR32 produces and secretes substantial amounts of TRH-immunoreactivity (TRH-IR) as measured with radioimmunoassay (RIA) using the nonspecific antiserum 4319.
Greef, W.J. (W.) de, Klootwijk, W. (Willem), Linkels, E., Rondeel, J.M.M. (Jan), Visser, T.J. (Theo)   +4 more
core   +1 more source

PET Study in a Patient with Spinocerebellar Degeneration before and after Long-Term Administration of Thyrotropin Releasing Hormone

Behavioural Neurology, 1996
We studied the chronic effect of thyrotropin releasing hormone (TRH) in a patient with spinocerebellar degeneration by measuring cerebral metabolic rate for glucose (CMRG1c) using 2-[18F]fluoro-2-deoxy-D-glucose (18FDG) and positron emission tomography ...
H. Tanji, H. Nagasawa, T. Hayashi, H. Onodera, T. Fujiwara, M. Itoh, T. Ido, Y. Itoyama   +7 more
doaj   +1 more source

Parathyroid localization [PDF]

, 1986
Twenty-nine consecutive patients with suspected primary hyperparathyroidism were examined preoperatively using ultrasound, sonographically guided fine needle aspiration, and aspirate immunostaining for PTH.
Borisch, B., Gutekunst, R., Hafermann, W., Kiffner, E., Löhrs, U., Scriba, Peter Christian, Thies, E., Valesky, A.   +7 more
core   +1 more source

Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor [PDF]

Frontiers in Endocrinology, 2012
Taltirelin (TAL) is a thyrotropin-releasing hormone (TRH) analog that is approved for use in humans in Japan. In this study, we characterized TAL binding to and signaling by the human TRH receptor (TRH-R) in a model cell system. We found that TAL exhibited lower binding affinities than TRH and lower signaling potency via the inositol-1,4,5 ...
Thirunarayanan, Nanthakumar, Raaka, Bruce M., Gershengorn, Marvin C.   +2 more
openaire   +3 more sources

The hypothalamic–pituitary–thyroid axis is intact in male Irs4 knockout mice

European Thyroid Journal
Objective: Loss of function mutations in the insulin receptor substrate 4 (IRS4) gene cause a rare form of X-linked congenital central hypothyroidism in boys and men.
Emilie Brûlé, Xiang Zhou, Ying Wang, Evan R S Buddle, Luisina Ongaro, Mary Loka, Anita Boelen, Daniel J Bernard   +7 more
doaj   +1 more source

The G alpha q and G alpha 11 proteins couple the thyrotropin-releasing hormone receptor to phospholipase C in GH3 rat pituitary cells [PDF]

, 1992
Thyrotropin-releasing hormone stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) in GH3 cell membranes. The stimulation of the phosphoinositide phospholipase C (PI/PLC) activity can be blocked by incubation of GH3 membranes with ...
Aragay, Anna M., Katz, Arieh, Simon, Melvin I.   +2 more
core  

The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFβ and Activin pathways [PDF]

, 2017
IGSF1 (Immunoglobulin Superfamily 1) gene defects cause central hypothyroidism and macroorchidism. However, the pathogenic mechanisms of the disease remain unclear.
Alvarez, C.V. (Clara V.), Barrio, R. (Raquel), Cameselle-Teijeiro, J.M. (José Manuel), De Miguel, M.P. (María P.), Díaz-Rodríguez, E. (Esther), Escudero, A. (Adela), Fernández, A. (Ana), Garcia-Rendueles, A.R. (Angela R.), García, M. (Marta), García-Lavandeira, M. (Montserrat), Gorbenko del Blanco, D. (Darya), Hinkle, P.M. (Patricia M.), Hokken-Koelega, A.C.S. (Anita), Lapunzina, P. (Pablo), Matre, V. (Vilborg), Moreno, J.C. (José C.), Nevado, J. (Julián), Nistal, M. (Manuel), Rijke, Y.B. (Yolanda) de, Vallespín, E. (Elena)   +19 more
core   +2 more sources