Results 21 to 30 of about 89,614 (169)

Optimal controlling of anti-TGF- $$\beta$$ β and anti-PDGF medicines for preventing pulmonary fibrosis

Scientific Reports, 2023
In the repair of injury, some transforming growth factor- $$\beta$$ β s (TGF- $$\beta$$ β s) and platelet-derived growth factors (PDGFs) bind to fibroblast receptors as ligands and cause the differentiation of fibroblasts into myofibroblasts.
Fatemeh Bahram Yazdroudi, Alaeddin Malek
doaj   +1 more source

Induction of inflammatory cytokines and toll-like receptors in chickens infected with avian H9N2 influenza virus

Veterinary Research, 2011
H9N2 influenza virus is endemic in many Asian countries and is regarded as a candidate for the next human pandemic. Knowledge of the induction of inflammatory responses and toll-like receptors (TLRs) in chickens infected with H9N2 is limited.
Nang Nguyen, Lee Joo, Song Byung, Kang Young, Kim Hyun, Seo Sang   +5 more
doaj   +1 more source

An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases. [PDF]

PLoS ONE, 2015
The epidermal growth factor receptor (EGFR) is overexpressed in approximately 90% of head and neck squamous cell carcinomas (HNSCC), and molecularly targeted therapy against the EGFR with the monoclonal antibody cetuximab modestly increases overall ...
Emily K Kleczko, Jihye Kim, Stephen B Keysar, Lydia R Heasley, Justin R Eagles, Matthew Simon, Marianne E Marshall, Katherine R Singleton, Antonio Jimeno, Aik-Choon Tan, Lynn E Heasley   +10 more
doaj   +1 more source

Development of Normal and Cleft Palate: A Central Role for Connective Tissue Growth Factor (CTGF)/CCN2

Journal of Developmental Biology, 2018
Development of the palate is the result of an organized series of events that require exquisite spatial and temporal regulation at the cellular level. There are a myriad of growth factors, receptors and signaling pathways that have been shown to play an ...
Joseph T. Tarr, Alex G. Lambi, James P. Bradley, Mary F. Barbe, Steven N. Popoff   +4 more
doaj   +1 more source

Precursors and preinvasive lesions of the breast: the role of molecular prognostic markers in the diagnostic and therapeutic dilemma

World Journal of Surgical Oncology, 2007
Precursors and preinvasive lesions of the breast include atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and lobular neoplasia (LN).
Zografos George C, Sergentanis Theodoros N, Zagouri Flora   +2 more
doaj   +1 more source

Three-Dimensional Culture of Human Dental Pulp Tissue: A Preliminary Experimental In Vitro Model for Regenerative Endodontic Procedures

Dental Hypotheses, 2023
Introduction: Dental pulp regeneration is fundamental in dentistry and endodontics; however, few in vitro experimental models are available to study its biological process.
Saber Khazaei, Rezvan Amirkhani, Azam Bozorgi, Mozafar Khazaei   +3 more
doaj   +1 more source

Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture

Cell Communication and Signaling, 2010
Background Uterine leiomyomas (fibroids) are benign smooth muscle tumors that often contain an excessive extracellular matrix (ECM). In the present study, we investigated the interactions between human uterine leiomyoma (UtLM) cells and uterine leiomyoma-
Robboy Stanley J, Walmer David K, Kissling Grace E, Castro Lysandra, Wang Lu, Swartz Carol D, Zheng Xaiolin, Yu Linda, Moore Alicia B, Dixon Darlene   +9 more
doaj   +1 more source

Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist. [PDF]

PLoS ONE, 2010
Transforming growth factor-beta (TGFbeta) homologues form a diverse superfamily that arose early in animal evolution and control cellular function through membrane-spanning, conserved serine-threonine kinases (RII and RI receptors).
Jie Zhu, Edward L Braun, Satomi Kohno, Monica Antenos, Eugene Y Xu, Robert W Cook, S Jack Lin, Brandon C Moore, Louis J Guillette, Theodore S Jardetzky, Teresa K Woodruff   +10 more
doaj   +1 more source

TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study

BMC Cancer, 2007
Background Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter.
Guo Qun, Penney Kathryn, Cox David G, Hankinson Susan E, Hunter David J   +4 more
doaj   +1 more source

Chimeric Peptides from Californiconus californicus and Heterodontus francisci with Antigen-Binding Capacity: A Conotoxin Scaffold to Create Non-Natural Antibodies (NoNaBodies)

Toxins, 2023
Research into various proteins capable of blocking metabolic pathways has improved the detection and treatment of multiple pathologies associated with the malfunction and overexpression of different metabolites.
Salvador Dueñas, Teresa Escalante, Jahaziel Gasperin-Bulbarela, Johanna Bernáldez-Sarabia, Karla Cervantes-Luévano, Samanta Jiménez, Noemí Sánchez-Campos, Olivia Cabanillas-Bernal, Blanca J. Valdovinos-Navarro, Angélica Álvarez-Lee, Marco A. De León-Nava, Alexei F. Licea-Navarro   +11 more
doaj   +1 more source