Results 51 to 60 of about 89,614 (169)

Reversing EGFR Mediated Immunoescape by Targeted Monoclonal Antibody Therapy

Frontiers in Pharmacology, 2017
Uncontrolled growth is a signature of carcinogenesis, in part mediated by overexpression or overstimulation of growth factor receptors. The epidermal growth factor receptor (EGFR) mediates activation of multiple oncogenic signaling pathways and escape ...
Fernando Concha-Benavente, Fernando Concha-Benavente, Robert L. Ferris, Robert L. Ferris   +3 more
doaj   +1 more source

HR+HER2− breast cancers with growth factor receptor–mediated EMT have a poor prognosis and lapatinib downregulates EMT in MCF-7 cells

Tumor Biology, 2017
Despite an overall good prognosis, a significant proportion of patients with hormone receptor positive human epidermal growth factor receptor 2 negative breast cancers develop distant metastases.
Krisha Desai, Radhika Aiyappa, Jyothi S Prabhu, Madhumathy G Nair, Patrick Varun Lawrence, Aruna Korlimarla, Anupama CE, Annie Alexander, Rohini S Kaluve, Suraj Manjunath, Marjorrie Correa, BS Srinath, Shekhar Patil, Anjali Kalamdani, MSN Prasad, TS Sridhar   +15 more
doaj   +1 more source

Altered Brain Expression of Insulin and Insulin-Like Growth Factors in Frontotemporal Lobar Degeneration: Another Degenerative Disease Linked to Dysregulation of Insulin Metabolic Pathways

ASN Neuro, 2019
Background Frontotemporal lobar degeneration (FTLD) is the third most common dementing neurodegenerative disease with nearly 80% having no known etiology. Objective Growing evidence that neurodegeneration can be linked to dysregulated metabolism prompted
Connie J. Liou, Ming Tong, Jean P. Vonsattel, Suzanne M. de la Monte   +3 more
doaj   +1 more source

The Role of TGF-β and Its Receptors in Gastrointestinal Cancers

Translational Oncology, 2019
Early detection of gastrointestinal tumors improves patient survival. However, patients with these tumors are typically diagnosed at an advanced stage and have poor prognosis. The incidence and mortality of gastrointestinal cancers, including esophageal,
Jingwen Luo, Xu-Qiao Chen, Ping Li
doaj   +1 more source

Epigallocatechin-3-gallate suppresses transforming growth factor-beta signaling by interacting with the transforming growth factor-beta type II receptor

World Journal of Experimental Medicine, 2013
Epigallocatechin-3-gallate suppresses transforming growth factor-beta signaling by interacting with the transforming growth factor-beta type II ...
Masaki Tabuchi, Sumio Hayakawa, Eiko Honda, Kana Ooshima, Tatsuki Itoh, Koji Yoshida, Ah-Mee Park, Hideaki Higashino, Mamoru Isemura, Hiroshi Munakata   +9 more
openaire   +1 more source

Small-Dose Sunitinib Modulates p53, Bcl-2, STAT3, and ERK1/2 Pathways and Protects against Adenine-Induced Nephrotoxicity

Pharmaceuticals, 2020
The therapeutic use of numerous pharmacological agents may be limited due to their nephrotoxicity and associated kidney injury. The aim of our study is to test the hypothesis that the blockade of tyrosine kinase-linked receptors signaling protects ...
Mohamed A. Saleh, Ahmed M. Awad, Tarek M. Ibrahim, Nashwa M. Abu-Elsaad   +3 more
doaj   +1 more source

Homomeric interactions between type II transforming growth factor-beta receptors.

Journal of Biological Chemistry, 1994
Transforming growth factor-beta (TGF-beta) binds with high affinity to three cell-surface receptors. Both type I and II receptors are transmembrane serine/threonine kinases and thought to mediate TGF-beta responses by forming a heteromeric complex in the presence of TGF-beta. We investigated whether the type II receptors form a homomeric complex in the
R H, Chen, R, Derynck
openaire   +2 more sources

Association between a history of hypothyroidism and incident chronic kidney disease and potential mediators: A cohort study with Mendelian randomization analysis

Journal of International Medical Research
Objective To investigate the association between hypothyroidism and incident chronic kidney disease and identify potential mediators. Methods This study included a retrospective cohort and Mendelian randomization analysis.
Yaofang Zhang, Yue Shen, Aiwen Shen, Yuqi Shen, Zhu Zhu, Yining He, Wenji Wang, Xuezhu Li, Xiao Bi, Feng Ding   +9 more
doaj   +1 more source

In Vitro and In Silico Wound-Healing Activity of Two Cationic Peptides Derived from Cecropin D in Galleria mellonella

Antibiotics
Background: Chronic wounds pose a significant public health challenge due to high treatment costs and the limited efficacy of current therapies.
Sandra Patricia Rivera-Sanchez, Iván Darío Ocampo-Ibáñez, Maria Camila Moncaleano, Yamil Liscano, Liliana Janeth Flórez Elvira, Yesid Armando Aristizabal Salazar, Luis Martínez-Martínez, Jose Oñate-Garzon   +7 more
doaj   +1 more source

Regulation of epithelial growth factor receptors by the oncoprotein E5 during the HPV16 differentiation-dependent life cycle

Tumour Virus Research
Human papillomavirus (HPV) 16 infection initiates upon viral entry into the basal cells of the epithelium. The virus manipulates signaling pathways to complete its life cycle, which depends on cellular differentiation.
Mariano A. Molina, Sneha Biswas, Omar Jiménez-Vázquez, Jason M. Bodily   +3 more
doaj   +1 more source