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Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart
Circulation, 1996Background Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine that produces negative inotropic effects in the heart. Recently, elevated levels of TNF-α have been reported in patients with advanced congestive heart failure.
G, Torre-Amione +6 more
semanticscholar +5 more sources
Signal transduction by tumor necrosis factor receptors
Cellular Signalling, 2012Tumor necrosis factor (TNF) is a key mediator in the inflammatory response which is implicated in the onset of a number of diseases. Research on TNF led to the characterization of the largest family of cytokines known until now, the TNF superfamily, which exert their biological effects through the interaction with transmembrane receptors of the TNFR ...
Lucía, Cabal-Hierro, Pedro S, Lazo
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Receptors | Tumor Necrosis Factor Receptors
Encyclopedia of Biological Chemistry III, 2021Timothy C. Cheung +2 more
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The Tumor Necrosis Factor Ligand and Receptor Families
New England Journal of Medicine, 1996Tumor necrosis factor (TNF) and lymphotoxin-α were isolated more than 10 years ago, on the basis of their ability to kill tumor cells in vitro and to cause hemorrhagic necrosis of transplantable tumors in mice.1 The complementary DNAs and genes encoding each protein were cloned immediately thereafter.2,3 Concurrently, a factor known as cachectin was ...
BAZZONI, Flavia, BEUTLER B.
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TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
Annual Review of Immunology, 1999▪ Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-α, LT-α, LT-β, and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF receptor (CD120a), the p75 TNF receptor (CD120b), the lymphotoxin beta receptor (LTβR), and herpes virus entry mediator (HVEM) to control a wide range of innate and ...
D, Wallach +5 more
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Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target
Expert opinion on therapeutic targets, 2019Introduction: Tumor necrosis factor (TNF) receptor 2 (TNFR2) is one of two receptors of the cytokines, TNF and lymphotoxin-α. TNFR1 is a strong inducer of proinflammatory activities.
Juliane Medler, H. Wajant
semanticscholar +1 more source
Veterinary Immunology and Immunopathology, 2004
Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the tumor necrosis factor receptor (TNFR) superfamily. In this study, we cloned and characterized two genes that encode chicken TNFR-II and TRAF5.
Sayed Abdalla, Abdalla +3 more
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Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the tumor necrosis factor receptor (TNFR) superfamily. In this study, we cloned and characterized two genes that encode chicken TNFR-II and TRAF5.
Sayed Abdalla, Abdalla +3 more
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International Journal of Hematology, 2006
The interactions between members of the tumor necrosis factor (TNF) family and their specific receptors (TNFRs) are influential in controlling cell division, life, and death. Recent evidence suggests that these interactions control the functionality and longevity of many types of cells involved in immune responses.
Takanori, So +2 more
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The interactions between members of the tumor necrosis factor (TNF) family and their specific receptors (TNFRs) are influential in controlling cell division, life, and death. Recent evidence suggests that these interactions control the functionality and longevity of many types of cells involved in immune responses.
Takanori, So +2 more
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Immunobiology of Tumor Necrosis Factor Receptor Superfamily
Immunologic Research, 2002The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The number of recognized members of the
Tong, Zhou +2 more
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Assay of Soluble Tumor Necrosis Factor Receptors
2003Over the last decade, numerous basic biological as well as experimental and clinical studies have firmly established the significance of tumor necrosis factor (TNF) as a principal proximal mediator of sepsis (1-4). One of the major insights that has emerged during recent years has been that under physiological circumstances, TNF activity is tightly ...
Boumaand, M.G., Buurman, W.A.
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