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Tumor necrosis factor receptors-structure and function
Immunologic Research, 1992Tumor necrosis factors (TNFs) have been a focus of research for well over a decade now. The identification and recent molecular cloning of two different types of cell-surface TNF receptors will shed further light on the mode of action of these pleiotropic cytokines.
J, Rothe +3 more
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3D Modeling of Tumor Necrosis Factor Receptor and Tumor Necrosis Factor‐bound Receptor Systems
Molecular Informatics, 2019AbstractThe interactions between the tumor necrosis factor (TNF) and its receptor molecule are responsible for various signaling networks that are central to the functioning of human immune homeostasis. The present work is a computational study of certain structural aspects of this cell‐signaling protein, specifically focusing on the molecular level ...
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Tumor necrosis factor-? and tumor necrosis factor receptors in human heart failure
Heart Failure Reviews, 1996The basic mechanisms that are responsible for the development and progression of congestive heart failure are not known. Although clinicians have traditionally viewed heart failure as a hemodynamic disorder related to left ventricular pump dysfunction, one of the more recent concepts that has emerged is that the development and progression of heart ...
Biykem Bozkurt +4 more
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The nerve growth factor/tumor necrosis factor receptor family
Journal of Leukocyte Biology, 1996Abstract Receptors in the nerve growth factor/tumor necrosis factor receptor family are characterized by the presence of cysteine-rich motifs of ~40 amino acids in the extracellular domain. The ligands are type II transmembrane proteins with β-strands that form a jelly-roll β-sandwich.
Lotz, Martin +3 more
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Tumor necrosis factor family ligand–receptor binding
Current Opinion in Structural Biology, 2004Ligands and receptors of the tumor necrosis factor (TNF) superfamily have pivotal roles in the development and function of the immune system. The growing pool of data on TNF from structural and biochemical studies suggests that the higher order clustering of TNF family ligands could play an essential role in signal transduction initiation for this ...
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Tumor Necrosis Factor Receptors Encoded by Poxviruses
Molecular Genetics and Metabolism, 1999Poxviruses encode several cytokine response modifying (Crm) proteins. The Crm proteins possess sequence homology to several human proteins important in immunity. This homology and the conservation of Crm proteins among poxvirus strains suggest an immunomodulatory function that provides a survival advantage to the virus.
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Tumor necrosis factor receptor superfamily.
Journal of inflammation, 1997Tumor necrosis factor (TNF) is a powerful cytokine which is involved in the immune and pro-inflammatory response. The TNF receptors (TNF-R1 and TNF-R2) are the sole mediators of TNF signaling. The receptors consist of a disulfide rich domain which recognizes TNF, a transmembrane helix, and a cytoplasmic domain.
J H, Naismith, S R, Sprang
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The p70 tumor necrosis factor receptor mediates cytotoxicity
Cell, 1992Tumor necrosis factor alpha (TNF) selectively kills tumor cells, but this specificity is not clearly understood. Two distinctly different cell surface receptors (TNFRs), proteins of 55 kd (p55) and 70-80 kd (p70), mediate TNF action. Mouse TA1 cells are not killed by human (h) TNF, but are killed by mouse (m) TNF alone.
R A, Heller, K, Song, N, Fan, D J, Chang
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Tumor necrosis factor receptors in the pituitary cells
Brain Research, 1997To clarify the site and mode of action of tumor necrosis factor (TNF) in the pituitary, we studied the effects, binding sites of TNF and its receptor mRNA in the two types of mouse pituitary-derived cell lines, AtT-20, ACTH-producing cells and TtT/GF, folliculo-stellate (FS)-like cells.
H, Kobayashi +9 more
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Tumor Necrosis Factor Ligand-Receptor Superfamily and Arthritis
2005The current studies of apoptosis in rheumatoid arthritis (RA) suggest that the TNF ligand-receptor superfamily (TNFRsF) molecules, downstream pathways (activation of proapoptosis or anti-apoptosis pathway), cell types (lymphocytes and synovial fibroblast), and the mechanism that triggers apoptosis (tolerance induction-related, downmodulation of ...
Hui-Chen, Hsu, Yalei, Wu, John D, Mountz
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