Results 141 to 150 of about 14,304 (250)
Inhibiting the urokinase-type plasminogen activator receptor system recovers STZ-induced diabetic nephropathy. [PDF]
, 2019 The urokinase‐type plasminogen activator (uPA) receptor (uPAR) participates to the mechanisms causing renal damage in response to hyperglycaemia. The main function of uPAR in podocytes (as well as soluble uPAR ‐(s)uPAR‐ from circulation) is to regulate ...
Svelto M +9 more
core +1 more source
Brain and Behavior, Volume 16, Issue 6, June 2026.In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence +14 more
wiley +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun +7 more
wiley +1 more source
, 2020 The major proteases that constitute the fibrinolysis system are tightly regulated. Protease inhibitors target plasmin, the protease responsible for fibrin degradation, and the proteases that convert plasminogen into plasmin, including tissue-type ...
Zampieri, Carlotta, Gonias, Steven L
core +1 more source
Programmed Cell Death in Chronic Rhinosinusitis
Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu +5 more
wiley +1 more source
Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma
eFood, Volume 7, Issue 3, June 2026.Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie +5 more
wiley +1 more source
Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation [PDF]
, 2006 It has been questioned whether there are receptors for urokinase-type plasminogen activator (uPA) that facilitate plasminogen activation other than the high affinity uPA receptor (uPAR/CD87) since studies of uPAR knockout mice did not support a major ...
Majumdar, Mousumi +10 more
core
Expression of plasminogen/plasmin receptors on human glomerular epithelial cells
, 1994 The aim of the present study was to display plasminogen/plasmin receptors on human glomerular epithelial cell (HGEC) membranes and to determine the properties of receptor-bound plasminogen at the cell surface.
M. N. Peraldi +5 more
core +1 more source
Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.Pretreatment with New Zealand blackcurrant anthocyanins nonsignificantly reduced TNF‐α–induced PAI‐1 release in bronchial epithelial cells. The small sample size may have influenced the lack of statistical significance. This study provides preliminary evidence of possible effects of NZBC anthocyanins on PAI‐1 secretion but warrants further extensive ...
Madiha Ajaz +5 more
wiley +1 more source