Results 41 to 50 of about 26,499 (240)

Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]

, 2015
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
core   +3 more sources

Soluble urokinase-type plasminogen activator receptor and urokinase-type plasminogen activator receptor contribute to chemoresistance in leukemia

Oncology Letters, 2017
The soluble urokinase-type plasminogen activator receptor (suPAR) and the urokinase-type plasminogen activator receptor (uPAR) have been proposed as useful biomarkers of tumor progression. Recently, suPAR was associated with chemoresistance in lung cancer. However, its clinical significance in leukemia has not previously been investigated.
Hong, Guo, Lan-Xia, Zhou, Haizhen, Ma, Bei, Liu, Juan, Cheng, Yun-Yun, Ma, Li, Zhao   +6 more
openaire   +3 more sources

PAI-1: An Integrator of Cell Signaling and Migration

International Journal of Cell Biology, 2011
Cellular migration, over simple surfaces or through complex stromal barriers, requires coordination between detachment/re-adhesion cycles, involving structural components of the extracellular matrix and their surface-binding elements (integrins), and the
Ralf-Peter Czekay, Cynthia E. Wilkins-Port, Stephen P. Higgins, Jennifer Freytag, Jessica M. Overstreet, R. Matthew Klein, Craig E. Higgins, Rohan Samarakoon, Paul J. Higgins   +8 more
doaj   +1 more source

PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology [PDF]

, 2018
The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling.
Azmoon, Pardis, Banki, Michael A, Campana, Wendy M, Gilder, Andrew S, Gonias, Steven L, Mantuano, Elisabetta   +5 more
core   +2 more sources

Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer [PDF]

EJNMMI Research, 2020
AbstractThe urokinase plasminogen activator receptor (uPAR) plays a multifaceted role in almost any process where migration of cells and tissue-remodeling is involved such as inflammation, but also in diseases as arthritis and cancer. Normally, uPAR is absent in healthy tissues.
Baart, V.M., Houvast, R.D., Geus-Oei, L.F. de, Quax, P.H.A., Kuppen, P.J.K., Vahrmeijer, A.L., Sier, C.F.M.   +6 more
openaire   +4 more sources

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours [PDF]

, 2016
Natural killer (NK) lymphocytes are part of the innate immune system and are important in immune protection against tumourigenesis. NK cells display a broad repertoire of activating and inhibitory cell surface receptors that regulate NK cell activity ...
Filtjens, Jessica, Keirsse, Jiri, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Taghon, Tom, Taveirne, Sylvie, Van Acker, Aline, Van Ammel, Els, Van Ginderachter, Jo A, Vandekerckhove, Bart   +10 more
core   +2 more sources

Urokinase plasminogen activator receptor: Prognostic biomarker for endometrial cancer [PDF]

Proceedings of the National Academy of Sciences, 2002
Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. However, reliable diagnostic or prognostic tumor markers have not been identified for endometrial cancer. In this study, we examined whether urokinase plasminogen activator receptor (UPAR), a glycosyl-phosphatidylinositol-linked membrane protein, is ...
Sanaz, Memarzadeh, Katherine R, Kozak, Lisbeth, Chang, Sathima, Natarajan, Peter, Shintaku, Srinivasa T, Reddy, Robin, Farias-Eisner, Sanaz, Memarzedeh   +7 more
openaire   +2 more sources

Changes in serum angiogenic factors among patients with acute pain and subacute pain

Frontiers in Molecular Neuroscience, 2022
Screening serum biomarkers for acute and subacute pain is important for precise pain management. This study aimed to examine serum levels of angiogenic factors in patients with acute and subacute pain as potential biomarkers. Serum samples were collected
Xuewei Yang, Chunmei Yuan, Huanling Wang, Yunxia Wang, Mei Liu, Zongjin Li, Jun Zhang, Jun Zhang   +7 more
doaj   +1 more source

The murine urokinase-type plasminogen activator receptor gene

Journal of Biological Chemistry, 1994
The murine urokinase-type plasminogen activator receptor (uPAR) gene has been isolated and its complete nucleotide sequence established. The gene is organized into seven exons comprising 9.5% of the 13,207-base pair region that spans the interval between the transcription initiation and polyadenylation sites.
T T, Suh, C, Nerlov, K, Danø, J L, Degen   +3 more
openaire   +2 more sources

Urokinase type plasminogen activator receptor expression in colorectal neoplasms [PDF]

Gut, 1998
Background—The urokinase type plasminogen activator receptor (uPAR) may play a critical role in cancer invasion and metastasis.Aims—To study the involvement of uPAR in colorectal carcinogenesis.Methods—The cellular expression and localisation of uPAR were investigated in colorectal adenomas and invasive carcinomas by in situ hybridisation ...
S, Suzuki, Y, Hayashi, Y, Wang, T, Nakamura, Y, Morita, K, Kawasaki, K, Ohta, N, Aoyama, S R, Kim, H, Itoh, Y, Kuroda, W F, Doe   +11 more
openaire   +2 more sources