Results 61 to 70 of about 26,499 (240)

Role of genetic polymorphisms in tumour angiogenesis [PDF]

, 2002
Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression.
A Compagni, A Panahloo, AG Wilson, AH Hajeer, AK Daly, B Conne, B Smolarz, B Zhang, B Zhang, BK Sim, C Sgadari, CD Lucke, CJ Powers, CJ Watson, CK Goldman, CP Dinney, CR Weinberg, CT To, D Giri, DJ Lindner, DM Turner, E Van Belle, EA Garbett, F Andreotti, F Bazzoni, F Janicke, FA Ferrer, G Ghilardi, G Messer, GA Stanczuk, GC Johnson, H Nekarda, H Pedersen, H Takayama, I Golovleva, IF Dunn, J Bange, J Blasiak, J Muldoon, JA Foekens, JH Bream, JH Jang, JH Lee, JL Rutter, K Koli, K Shingu, K Tsukasaki, K Warzocha, KC Hart, KM Neilson, KS Park, KS Park, L Pertovaara, L Strizzi, LJ Rosenwasser, M Beranek, M Gregoire, M Jeffers, M Shahbazi, M Shahbazi, M Toi, M W R Reed, M Yokota, MD Barber, ML Biondi, MR Cardillo, MR Cardillo, MR Cardillo, MR Kohonen-Corish, MS O'Reilly, N J Brown, N Yoshimura, NJ Risch, P Iughetti, R Hildenbrand, RC Borghaei, RK Jain, S Curran, S Dawson, S Jormsjo, S Mestiri, S P Balasubramanian, S Shimajiri, S Ye, S Ye, S Yoshida, SA Rabbani, SL McCarron, SP Balasubramanian, SS Apte, T Higuchi, T Shimura, T Shimura, T Veikkola, V Chopra, V Pravica, W Renner, WH Jang, WM Howell, WM Howell, Y Hasegawa, Y Kanamori, Y Nishioka, Y Zhu   +103 more
core   +2 more sources

Upregulation of Monocyte Urokinase Plasminogen Activator Receptor during Human Endotoxemia [PDF]

Infection and Immunity, 2000
ABSTRACTThe receptor for urokinase-type plasminogen activator (uPAR) (CD87) plays an important role in leukocyte adhesion and migration. To assess the effect of endotoxin on cellular uPAR, uPAR expression was determined on leukocytes by fluorescence-activated cell sorter analysis in seven healthy subjects following intravenous injection of endotoxin ...
Dekkers, P. E., ten Hove, T., te Velde, A. A., van Deventer, S. J., van der Poll, T.   +4 more
openaire   +3 more sources

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, EarlyView.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source

Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]

, 2014
Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Hall, Ian P., Portelli, Michael A., Sayers, Ian   +2 more
core  

Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]

, 2010
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Debela, Emami, Freije, Frenette, Gomis, Hollenberg, Itoh, Jung, Lopez, Ohler, Pampalakis, Ramsay, Ries, Rittenhouse, Ryu, Shaw, Sperl, Takayama, Takayama, Tye, Yoon, Yoon   +21 more
core   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Measuring the metastatic potential of cancer cells [PDF]

, 1993
Cancer cells must secrete proteolytic enzymes to invade adjacent tissues and migrate to a new metastatic site. Urokinase (uPA) is a key enzyme related to metastasis in cancers of the lung, colon, gastric, uterine, breast, brain, and malignant melanoma. A
Atassi, M. Z., Gratzner, Howard, Morrison, Dennis R.   +2 more
core   +1 more source

Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels [PDF]

, 2013
The soluble cleaved urokinase plasminogen activator receptor (scuPAR) is a circulating protein detected in multiple diseases, including various cancers, cardiovascular disease, and kidney disease, where elevated levels of scuPAR have been associated with
Andrew J. Wardlaw, Behrendt N., Blasi F., Ceri E. Stewart, Dirkje S. Postma, Gerard H. Koppelman, Ian Sayers, Janine Altmuller, Judith M. Vonk, Maartje A. Nieuwenhuis, Martin J. Connolly, Mateusz Siedlinski, Mazzieri R., Michael A. Portelli, Miriam F. Moffatt, Peter Nurnberg, Plesner T., Ploug M., Schmaier A. H., Sidenius N., Stewart C. E., Stewart C. E., Stuart G. Parker, Tan X., Team R. C.   +24 more
core   +5 more sources

Immunohistochemical localization of urokinase-type plasminogen activator, type-1 plasminogen-activator inhibitor, urokinase receptor and α2-macroglobulin receptor in human breast carcinomas [PDF]

International Journal of Cancer, 1996
We have investigated the localization of urokinase-type plasminogen activator (u-PA), type-1 plasminogen-activator inhibitor (PAI-1), u-PA receptor (u-PAR) and alpha(2)-macroglobulin- receptor/low-density-lipoprotein-receptor-related protein (alpha(2)MR/LRP) in human breast tumors by immunohistochemical methods.
Christensen, Lise, Wiborg Simonsen, Anna Carina, Heegaard, Christian Wurtz, Moestrup, Søren Kragh, Andersen, Johan A., Andreasen, Peter   +5 more
openaire   +3 more sources

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source