Results 81 to 90 of about 14,304 (250)

Expression of Urokinase-type Plasminogen Activator and Its Receptor in Keloids [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 2003
The urokinase-mediated plasminogen activation (uPA) system plays a central role in a number of cellular processes including tissue remodeling, cell migration, and angiogenesis. Elevated uPA activity has also been seen with tumor invasion and metastasis in a variety of malignancies.
Deirdre, Leake, Timothy D, Doerr, Glynis, Scott   +2 more
openaire   +2 more sources

Role of specific membrane receptors in urokinase dependent migration of human keratinocytes

, 1990
On the basis of both 125I-labeled plasminogen activator binding analysis and transmission electron microscopy studies of the interaction of a plasminogen activator/gold complex with cell membranes, we have found that human keratinocytes have specific ...
Lotti, T., Dini, Germana, Del Rosso, M., Grappone, Cecilia, Fimiani, M., Magnelli, Lucia, Pucci, Marco, Fibbi, G., Caldini, Riccardo, Panconesi, Emiliano, Dini, G., Pucci, M., Fibbi, Gabriella, Panconesi, E., Del Rosso, Mario, Caldini, R., Magnelli, L., Lotti, Torello, Grappone, C.   +18 more
core   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Biological and Clinical Significance of Non-canonical Ligands of Epithelial Nicotinic Acetylcholine Receptors

Journal of Pharmacological Sciences, 2008
Mucocutaneous keratinocytes and bronchial epithelial cells express nicotinic acetylcholine receptors (nAChRs). Emerging evidence indicates that nAChRs can be stimulated also by the tobacco-derived nitrosamines 4-(methylnitrosamino)-1-(3–pyridyl)-1 ...
Sergei A. Grando
doaj   +1 more source

A randomized trial of an early measles vaccine at 4½ months of age in Guinea-Bissau: sex-differential immunological effects. [PDF]

PLoS ONE, 2014
After measles vaccine (MV), all-cause mortality is reduced more than can be explained by the prevention of measles, especially in females.We aimed to study the biological mechanisms underlying the observed non-specific and sex-differential effects of MV ...
Kristoffer Jarlov Jensen, Mia Søndergaard, Andreas Andersen, Erliyani Sartono, Cesario Martins, May-Lill Garly, Jesper Eugen-Olsen, Henrik Ullum, Maria Yazdanbakhsh, Peter Aaby, Christine Stabell Benn, Christian Erikstrup   +11 more
doaj   +1 more source

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

Düzce Tıp Fakültesi Dergisi, 2021
Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types.
Mahmut Şenyurt, Engin Şebin, Sibel İba Yılmaz, Ali Batur, Orhan Delice, Omer Karasahin, Kadir Küçükceran   +6 more
doaj   +1 more source

A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?

, 2021
Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system.
Paul J. Declerck, Declerck, Paul J., Sillen, Machteld, Machteld Sillen   +3 more
core   +1 more source

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

The urokinase‐type‐plasminogen‐activator receptor (CD87) is a pleiotropic molecule [PDF]

European Journal of Biochemistry, 1998
Since its discovery over a decade ago, evidence has accumulated implicating the cell‐surface urokinase receptor (u‐PAR), in numerous biological processes. Most notable has been the identification of a critical role for u‐PAR in the regulation of cell‐surface plasminogen activation in physiological and pathological conditions.
A E, Dear, R L, Medcalf
openaire   +2 more sources

Exercise, cognition and Alzheimer’s disease: More is not necessarily better [PDF]

, 2005
Regional hypoperfusion, associated with a reduction in cerebral metabolism, is a hallmark of Alzheimer’s disease (AD) and contributes to cognitive decline. Cerebral perfusion and hence cognition can be enhanced by exercise.
Swaab, D.F., Scherder, E.J.A., Swaab, D, Luiten, P, Scherder, Erik,, Scherder, Erik, Eggermont, L, Swaab, Dick,, Eggermont, Laura, Luiten, P.G.M., Eggermont, L.H.P., Eggermont, Laura,, Scherder, E, Swaab, Dick, Luiten, Paul,, Luiten, Paul   +15 more
core   +1 more source