Results 81 to 90 of about 729,299 (226)

Prognostic value of urokinase plasminogen activator for prostatic carcinoma.

, 1994
The usefulness of routine clinical application of the urokinase plasminogen activator in prostate cancer was evaluated. The urokinase values of prostate cancer confined to the organ, with extraprostatic spread and with metastatic disease did not differ ...
Plas E, Lehmann K, Hauri D, Gautschi K
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, Volume 20, Issue 11, Page 2955-2973, November 2026.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, Volume 20, Issue 11, Page 2569-2583, November 2026.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease

Nature Communications
Coagulation factor XII (FXII) conveys various functions as an active protease that promotes thrombosis and inflammation, and as a zymogen via surface receptors like urokinase-type plasminogen activator receptor (uPAR).
Ahmed Elwakiel, Dheerendra Gupta, Rajiv Rana, Jayakumar Manoharan, Moh’d Mohanad Al-Dabet, Saira Ambreen, Sameen Fatima, Silke Zimmermann, Akash Mathew, Zhiyang Li, Kunal Singh, Anubhuti Gupta, Surinder Pal, Alba Sulaj, Stefan Kopf, Constantin Schwab, Ronny Baber, Robert Geffers, Tom Götze, Bekas Alo, Christina Lamers, Paul Kluge, Georg Kuenze, Shrey Kohli, Thomas Renné, Khurrum Shahzad, Berend Isermann   +26 more
doaj   +1 more source

The Plasma Proteome Mediates the Association Between Workplace Noise Exposure and Psychiatric Disorder Risk

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Workplace noise exposure was associated with adverse psychiatric outcomes and plasma proteomic alterations in the UK Biobank. Circulating proteins partially mediated associations with anxiety disorder and major depressive disorder (MDD), while workplace noise‐related protein risk scores provided proteomics‐based measures of individual susceptibility to
Xuan Zhao, Yan Fu, Dan‐Dan Zhang, Wei Xu, Hui‐Fu Wang, Wei Zhang, Jin‐Tai Yu, Lan Tan   +7 more
wiley   +1 more source

Transcriptomic Responses to Koi Herpesvirus in Isolated Blood Leukocytes from Infected Common Carp

Viruses
Koi herpesvirus (KHV, CyHV-3) causes severe economic losses in carp farms. Its eradication is challenging due to the establishment of latency in blood leukocytes and other tissues.
Irene Cano, Ellen Blaker, David Hartnell, Audrey Farbos, Karen A. Moore, Adele Cobb, Eduarda M. Santos, Ronny van Aerle   +7 more
doaj   +1 more source

Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells

BMC Cancer, 2011
Background A major problem with the use of current chemotherapy regimens for several cancers, including breast cancer, is development of intrinsic or acquired drug resistance, which results in disease recurrence and metastasis.
Choi Changsun, Kim Sunshin, Jeong Kyung-Chae, Song Ki-Hoon, Kang Ju-Hee, Lee Chang, Oh Seung   +6 more
doaj   +1 more source

Immunohistochemical staining of urokinase plasminogen activator-like and urokinase plasminogen activator receptor-like proteins in the urinary tract of healthy dogs

, 2006
OBJECTIVE: To determine distribution of urokinase plasminogen activator-like protein and urokinase plasminogen activator receptor-like protein in urinary tract tissues of healthy dogs. ANIMALS: 11 healthy dogs. PROCEDURES: Necropsy specimens from kidney,
Hosgood, Giselle, Bailey, Trina R, Sehgal, Inder, Paulsen, Daniel B   +3 more
core   +1 more source

A Single Smart Nanomaterial for Near‐Infrared‐Switchable Theranostics of Hemorrhage and Thrombosis via Photoacoustic Imaging

Small Science, Volume 6, Issue 11, November 2026.
A smart nanomaterial integrating Ag single atoms and nanoparticles on NiFe‐layered double hydroxides enables NIR‐switchable hemostasis and thrombolysis via photoelectric and photothermal effects. This platform allows real‐time photoacoustic imaging of active bleeding and exhibits rapid in vivo clearance, offering a dynamic theranostic strategy for ...
Yi Ye, Zhilu Sun, Daofu Wu, Jun’an Lai, Mingyue Yang, Zhiqiong Luo, Sha Cheng, Suwen Yang, Hong Zeng, Yinghui Li, Faguang Kuang, Baofei Sun, Wenxia Zhang, Xiaosheng Tang, Heng Luo, Guofeng Wu   +15 more
wiley   +1 more source

Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin

Cells
The soluble urokinase plasminogen activator receptor (suPAR) has been implicated in a wide range of pathological conditions including primary nephrotic syndromes and acute kidney injuries.
Eun Young Kim, Stuart E. Dryer
doaj   +1 more source