Results 91 to 100 of about 676,629 (244)

Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells

BMC Cancer, 2011
Background A major problem with the use of current chemotherapy regimens for several cancers, including breast cancer, is development of intrinsic or acquired drug resistance, which results in disease recurrence and metastasis.
Choi Changsun, Kim Sunshin, Jeong Kyung-Chae, Song Ki-Hoon, Kang Ju-Hee, Lee Chang, Oh Seung   +6 more
doaj   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Pemphigus IgG Induces Expression of Urokinase Plasminogen Activator Receptor on the Cell Surface of Cultured Keratinocytes [PDF]

, 1997
We previously found that the binding of pemphigus IgG to desmogleins caused marked activation of phospholipase C, a transient increase in inositol 1,4,5-trisphosphate production, and a concomitant increase in the intracellular calcium concentration in ...
Seishima, Mariko, Nojiri, Mari, Satoh, Shiho, Kitajima, Yasuo, Osada, Kazuko   +4 more
core   +1 more source

Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin

Cells
The soluble urokinase plasminogen activator receptor (suPAR) has been implicated in a wide range of pathological conditions including primary nephrotic syndromes and acute kidney injuries.
Eun Young Kim, Stuart E. Dryer
doaj   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)

Molecular Cancer, 2009
Introduction Studies in mammary cancer demonstrated that moderately high concentrations of molecular iodine (I2) have a antiproliferative and apoptotic effect either in vivo as in vitro, however the cellular intermediated involved in these effects has ...
Anguiano Brenda, Delgado Guadalupe, Vega-Riveroll Laura, Arroyo-Helguera Omar, García-Solís Pablo, Aceves Carmen   +5 more
doaj   +1 more source

Seminal Biomarkers and Sperm Proteomic Signatures Differentiate Acute and Chronic Male Accessory Gland Inflammation

Andrology, EarlyView.
ABSTRACT Background Male accessory gland inflammation (MAGI) comprises a heterogeneous group of inflammatory conditions that may differentially affect the seminal microenvironment and sperm function. However, whether transrectal ultrasound (TRUS)‐defined MAGI phenotypes correspond to distinct biological profiles remains insufficiently characterized ...
Emanuela Teveroni, Fiorella Di Nicuolo, Giorgia Mazzuccato, Alessandro Oliva, Emanuele Pierpaolo Vodola, Francesca Mancini, Carla Di Nardo, Edoardo Vergani, Michela Cicchinelli, Federica Iavarone, Cassandra Serantoni, Giuseppe Maulucci, Alessia Riente, Alfredo Pontecorvi, Andrea Urbani, Domenico Milardi, Silvia Baroni   +16 more
wiley   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

Real-Time Reverse-Transcription PCR to Quantify a Panel of 19 Genes in Breast Cancer: Relationships with Sentinel Lymph Node Invasion

The International Journal of Biological Markers, 2008
At the Centre Oscar Lambret, the anticancer centre of the North of France, sentinel lymph node (SLN) procedures are routinely performed for localized (T0–T1, N0, M0) breast carcinoma without any previous treatment, in order to prevent the deleterious ...
F. Révillion Dr., Ph.D., V. Lhotellier, L. Hornez, A. Leroy, M.C. Baranzelli, S. Giard, J. Bonneterre, J.P. Peyrat   +7 more
doaj   +1 more source

Modulation of CD44 Activity by A6-Peptide

Frontiers in Immunology, 2015
Hyaluronan (HA) is a nonsulfated glycosaminoglycan distributed throughout the extracellular matrix that plays a major role in cell adhesion, migration, and proliferation. CD44, a multifunctional cell surface glycoprotein, is a receptor for HA.
Malcolm eFinlayson
doaj   +1 more source