Results 91 to 100 of about 14,304 (250)

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Urokinase plasminogen activator receptor: Prognostic biomarker for endometrial cancer [PDF]

Proceedings of the National Academy of Sciences, 2002
Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. However, reliable diagnostic or prognostic tumor markers have not been identified for endometrial cancer. In this study, we examined whether urokinase plasminogen activator receptor (UPAR), a glycosyl-phosphatidylinositol-linked membrane protein, is ...
Sanaz, Memarzadeh, Katherine R, Kozak, Lisbeth, Chang, Sathima, Natarajan, Peter, Shintaku, Srinivasa T, Reddy, Robin, Farias-Eisner, Sanaz, Memarzedeh   +7 more
openaire   +2 more sources

Integrin-uPAR signaling leads to FRA-1 phosphorylation and enhanced breast cancer invasion

Breast Cancer Research, 2018
Background The Fos-related antigen 1 (FRA-1) transcription factor promotes tumor cell growth, invasion and metastasis. Phosphorylation of FRA-1 increases protein stability and function.
Matthew G. Annis, Veronique Ouellet, Jonathan P. Rennhack, Sylvain L’Esperance, Claudine Rancourt, Anne-Marie Mes-Masson, Eran R. Andrechek, Peter M. Siegel   +7 more
doaj   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Release of urokinase plasminogen activator receptor during urosepsis and endotoxemia [PDF]

Kidney International, 2001
The urokinase receptor (uPAR; CD87) is a multifunctional molecule involved in fibrinolysis, in proteolysis, in renal tubular functions, and in migration and adhesion of inflammatory cells to the site of infection.To gain insight into systemic and local release of uPAR and into its regulation during urosepsis, which is one of the leading causes of ...
Florquin, S., van den Berg, J. G., Olszyna, D. P., Claessen, N., Opal, S. M., Weening, J. J., van der Poll, T.   +6 more
openaire   +2 more sources

Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms

Allergy, EarlyView.
Short‐term exposure to SDS rapidly disrupts human skin barrier integrity within minutes, as detected by real‐time electrical impedance spectroscopy. SDS‐induced barrier dysfunction is driven by oxidative stress, leading to suppression of immune/barrier mediators and activation of stress, lipid remodeling, and epidermal differentiation pathways ...
Manru Li, Huseyn Babayev, Paolo D'Avino, Can Zeyneloğlu, Ceren Bicer, Duygu Yazici, Yagiz Pat, Per Svedenhag, Nicolas Gaudenzio, Cezmi A. Akdis, Yasutaka Mitamura   +10 more
wiley   +1 more source

Urokinase type plasminogen activator receptor expression in colorectal neoplasms [PDF]

Gut, 1998
Background —The urokinase type plasminogen activator receptor (uPAR) may play a critical role in cancer invasion and metastasis. Aims —To study the involvement of uPAR in colorectal carcinogenesis.
S, Suzuki, Y, Hayashi, Y, Wang, T, Nakamura, Y, Morita, K, Kawasaki, K, Ohta, N, Aoyama, S R, Kim, H, Itoh, Y, Kuroda, W F, Doe   +11 more
openaire   +2 more sources

The Multifaceted Role of Plasminogen in Cancer

, 2021
Fibrinolytic factors like plasminogen, tissue-type plasminogen activator (tPA), and urokinase plasminogen activator (uPA) dissolve clots. Though mere extracellular-matrix-degrading enzymes, fibrinolytic factors interfere with many processes during ...
Yousef Salama, Beate Heissig, Ko Okumura, Koichi Hattori, Taro Osada   +4 more
core   +1 more source

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Soluble Urokinase-Type Plasminogen Activator Receptor in FSGS [PDF]

Journal of the American Society of Nephrology, 2014
The soluble urokinase-type plasminogen activator receptor (suPAR) has been proposed as a candidate circulating factor causing FSGS.[1][1] In this issue of JASN , Cathelin et al. further examine the short-term effects of two different types of suPAR on the kidney filtration barrier.[2][2 ...
Jochen, Reiser, Harold, Chapman
openaire   +2 more sources