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Related Article from Urokinase-Type Plasminogen Activator Receptor: A Beacon of Malignancy?
, 2008 Related Article from Urokinase-Type Plasminogen Activator Receptor: A Beacon of ...
Ronny Drapkin (130800) +2 more
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British Journal of Pharmacology, Volume 183, Issue 22, Page 6685-6703, November 2026.Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier +2 more
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Molecular Cancer, 2009 Introduction Studies in mammary cancer demonstrated that moderately high concentrations of molecular iodine (I2) have a antiproliferative and apoptotic effect either in vivo as in vitro, however the cellular intermediated involved in these effects has ...
Anguiano Brenda +5 more
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Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy
Immunology &Cell Biology, Volume 104, Issue 10, Page 996-1014, November‐December 2026.IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
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, 2013 Effects of acute exercise and allopurinol administration on soluble urokinase plasminogen activator receptor (suPAR)
Sanchis Gomar F +6 more
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Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]
, 2003 Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito +6 more
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Lipoprotein(a), Endothelial Dysfunction and Cardiovascular Disease
Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.ABSTRACT Lipoprotein(a) (Lp(a)) is a particle similar to low‐density lipoprotein cholesterol and is associated with apolipoprotein (A). High Lp(a) levels are a genetic, independent risk factor for atherosclerotic cardiovascular disease (ASCVD). Endothelial cells, which form the continuous lining of the cardiovascular system, are crucial for vascular ...
Xianghui Zhou +5 more
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The International Journal of Biological Markers, 2008 At the Centre Oscar Lambret, the anticancer centre of the North of France, sentinel lymph node (SLN) procedures are routinely performed for localized (T0–T1, N0, M0) breast carcinoma without any previous treatment, in order to prevent the deleterious ...
F. Révillion Dr., Ph.D. +7 more
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Modulation of CD44 Activity by A6-Peptide
Frontiers in Immunology, 2015 Hyaluronan (HA) is a nonsulfated glycosaminoglycan distributed throughout the extracellular matrix that plays a major role in cell adhesion, migration, and proliferation. CD44, a multifunctional cell surface glycoprotein, is a receptor for HA.
Malcolm eFinlayson
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Regulation of urokinase plasminogen activator and plasminogen activator inhibitor-1 in murine breast cancer cells [PDF]
, 2011 Proteases are indispensable for tumor growth, angiogenesis, and metastasis. These proteases are produced by tumor cells, stromal cells, and by the host coagulation cascade.
McEachron, Troy Anthony
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