Results 111 to 120 of about 14,304 (250)

Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease

Nature Communications
Coagulation factor XII (FXII) conveys various functions as an active protease that promotes thrombosis and inflammation, and as a zymogen via surface receptors like urokinase-type plasminogen activator receptor (uPAR).
Ahmed Elwakiel, Dheerendra Gupta, Rajiv Rana, Jayakumar Manoharan, Moh’d Mohanad Al-Dabet, Saira Ambreen, Sameen Fatima, Silke Zimmermann, Akash Mathew, Zhiyang Li, Kunal Singh, Anubhuti Gupta, Surinder Pal, Alba Sulaj, Stefan Kopf, Constantin Schwab, Ronny Baber, Robert Geffers, Tom Götze, Bekas Alo, Christina Lamers, Paul Kluge, Georg Kuenze, Shrey Kohli, Thomas Renné, Khurrum Shahzad, Berend Isermann   +26 more
doaj   +1 more source

Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells

BMC Cancer, 2011
Background A major problem with the use of current chemotherapy regimens for several cancers, including breast cancer, is development of intrinsic or acquired drug resistance, which results in disease recurrence and metastasis.
Choi Changsun, Kim Sunshin, Jeong Kyung-Chae, Song Ki-Hoon, Kang Ju-Hee, Lee Chang, Oh Seung   +6 more
doaj   +1 more source

Urokinase-type plasminogek-activator receptor associates with a cell surface molecule in monocytic cells

, 1996
The urokinase-type plasminogen activator (uPA) is a specific protease which, by converting plasminogen into plasmin, can promote the degradation of the extracellular matrix.
Montuori N., Rossi G.
core   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Transcriptomic Responses to Koi Herpesvirus in Isolated Blood Leukocytes from Infected Common Carp

Viruses
Koi herpesvirus (KHV, CyHV-3) causes severe economic losses in carp farms. Its eradication is challenging due to the establishment of latency in blood leukocytes and other tissues.
Irene Cano, Ellen Blaker, David Hartnell, Audrey Farbos, Karen A. Moore, Adele Cobb, Eduarda M. Santos, Ronny van Aerle   +7 more
doaj   +1 more source

Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin

Cells
The soluble urokinase plasminogen activator receptor (suPAR) has been implicated in a wide range of pathological conditions including primary nephrotic syndromes and acute kidney injuries.
Eun Young Kim, Stuart E. Dryer
doaj   +1 more source

Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)

Molecular Cancer, 2009
Introduction Studies in mammary cancer demonstrated that moderately high concentrations of molecular iodine (I2) have a antiproliferative and apoptotic effect either in vivo as in vitro, however the cellular intermediated involved in these effects has ...
Anguiano Brenda, Delgado Guadalupe, Vega-Riveroll Laura, Arroyo-Helguera Omar, García-Solís Pablo, Aceves Carmen   +5 more
doaj   +1 more source

Immunolocalization of the receptors for urokinase plasminogen activator (uPAR) in bladder carcinoma

, 2003
The work reports the immunolocalization of the receptors for urokinase plasminogen activator (uPAR) in bladder ...
Baldelli B., Gazzanelli G., Fazioli F., Muzzonigro G., MALATESTA, Manuela, Vivani C., Milanese G.   +6 more
core  

Investigator‐Led Research to Improve the Diagnostic Assessment of Platelet Function Disorders: Reflections on the Challenges and Rewards

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Investigator‐led research and quality improvement initiatives have led to important improvements in the diagnostic assessment of platelet function disorders (PFD). Methods Personal reflections were used to summarize our contributions to knowledge on PFD diagnostic assessment, pathogenesis, and bleeding risks.
Catherine P. M. Hayward
wiley   +1 more source

Kinetics of the soluble urokinase plasminogen activator receptor (suPAR) in cirrhosis

PLOS ONE, 2019
The soluble urokinase plasminogen activator receptor (suPAR) is related to hepatic inflammation and fibrosis and has been suggested to participate in the development of liver cirrhosis. Therefore, the aim of the current study was to measure the concentration of suPAR in the hepatic vein of cirrhotic patients during a liver vein catheterization to ...
Emilie Garnæs, Christian Mortensen, Lise Hobolth, Ove Andersen, Jan Nehlin, Søren Møller   +5 more
openaire   +5 more sources