Results 101 to 110 of about 14,304 (250)

Cellular Degradation of Free and Inhibitor-bound Tissue-type Plasminogen Activator

, 2000
SummaryThe low density lipoprotein receptor-related protein (LRP) is a multiligand clearance receptor that removes free tissue-type plasminogen activator (t-PA) or complexes of t-PA with plasminogen activator inhibitor type 1 (PAI-1) from the blood ...
Egbert Kruithof, Chantal Camani, Olivier Gavin   +2 more
core   +1 more source

Circulating Soluble Urokinase Plasminogen Activator Receptor as a Predictive Indicator for COVID-19-Associated Acute Kidney Injury and Mortality: Clinical and Bioinformatics Analysis

, 2023
Urokinase receptors regulate the interplay between inflammation, immunity, and blood clotting. The soluble urokinase plasminogen activator system is an immunologic regulator affecting endothelial function and its related receptor; the soluble urokinase ...
Hassnaa M. Nassar, Mohamed Gamal Sakr, Jawaher A. Abdulhakim, Manal S. Fawzy, Noha M. Abd El-Fadeal, Hidi A. A. Abdellatif, Eman Riad, Mostafa Elsaied Elsayed Gomaa, Alhanouf I. Al-Harbi, Basma Osman Sultan   +9 more
core   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Structural Biology and Protein Engineering of Thrombolytics

Computational and Structural Biotechnology Journal, 2019
Myocardial infarction and ischemic stroke are the most frequent causes of death or disability worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently used for their treatment. Improving the effectiveness of thrombolytics
Jan Mican, Martin Toul, David Bednar, Jiri Damborsky   +3 more
doaj   +1 more source

Urokinase type plasminogen activator receptor (UPAR) as a new therapeutic target in cancer. [PDF]

, 2016
The urokinase (uPA)-type plasminogen activator receptor (uPAR) is a GPI-anchored receptor that focuses urokinase (uPA) proteolytic activity on the cell surface.
RAGNO, Pia, De Paulis, A, Pesapane, Ada, Giudice, Valentina, SELLERI, Carmine, ROSSI, FRANCESCA WANDA, Rossi, Fw, Montuori, N, DE PAULIS, AMATO, Pesapane, A, Giudice, V, MONTUORI, NUNZIA   +11 more
core   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors [PDF]

, 2017
The urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored cell membrane receptor that focuses urokinase (uPA) proteolytic activity on the cell surface.
Sabino De Placido, Valentina D’Amato, LAVECCHIA, ANTONIO, Paola Ciciola, Roberta Marciano, Di Mauro, Concetta, D'AMATO, VALENTINA, BIANCO, ROBERTO, Mauro, Concetta Di, Nicola Zambrano, MARCIANO, ROBERTA, Bianca Maria Veneziani, ZAMBRANO, NICOLA, Lucia Grumetto, Orsini, Roberta Clara, Giuseppe Pignataro, Francesca Monteleone, Roberta Rosa, BRUZZESE, DARIO, Fontanini, Gabriella, Giancarlo Troncone, Concetta Di Mauro, FORMISANO, LUIGI, TRONCONE, GIANCARLO, Alberto Servetto, Ada Pesapane, Roberta Clara Orsini, SERVETTO, ALBERTO, De Placido, Sabino, Luigi Formisano, Adele Servadio, Antonio Lavecchia, VENEZIANI, BIANCA MARIA, ROSA, ROBERTA, Antonino Iaccarino, PESAPANE, ADA, IACCARINO, ANTONINO, Servadio, Adele, MONTELEONE, FRANCESCA, GRUMETTO, LUCIA, Nunzia Montuori, Gabriella Fontanini, PIGNATARO, GIUSEPPE, Placido, Sabino De, Dario Bruzzese, CICIOLA, PAOLA, MONTUORI, NUNZIA, Roberto Bianco   +47 more
core   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor Mediate Human Stem Cell Tropism to Malignant Solid Tumors

Stem Cells, 2008
Abstract Human neural and mesenchymal stem cells have been identified for cell-based therapies in regenerative medicine and as vehicles for delivering therapeutic agents to areas of injury and tumors. However, the signals required for homing and recruitment of stem cells to these sites are not well understood.
Margarita, Gutova, Joseph, Najbauer, Richard T, Frank, Stephen Edward, Kendall, Anna, Gevorgyan, Marianne Z, Metz, Mark, Guevorkian, Marissa, Edmiston, Donghong, Zhao, Carlotta A, Glackin, Seung U, Kim, Karen S, Aboody   +11 more
openaire   +2 more sources

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source