Results 161 to 170 of about 14,521 (208)

Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract

Peptides, 1988
Vasoactive intestinal peptide (VIP) is a putative neurotransmitter in both the brain and peripheral tissues. To define possible target tissues of VIP we have used quantitative receptor autoradiography to localize and quantify the distribution of 125I-VIP receptor binding sites in the canine gastrointestinal tract.
R P, Zimmerman, T S, Gates, C R, Mantyh, S R, Vigna, C G, Boehmer, P W, Mantyh   +5 more
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Characterization of vasoactive intestinal peptide receptors on rat alveolar macrophages

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1994
In view of the evidence that vasoactive intestinal peptide (VIP) may modulate acute inflammatory injury in the lung, we investigated the presence and characteristics of VIP receptors on alveolar macrophages (AMs). We examined the binding of monoiodinated [Tyr(125I)10]-labeled VIP (125I-VIP) to rat AMs (> 96% pure), obtained from Sprague-Dawley rats
H, Sakakibara, K, Shima, S I, Said
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Receptors for vasoactive intestinal peptide and secretin on small intestinal epithelial cells

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1980
Binding of 125I-labeled vasoactive intestinal peptide (VIP) to dispersed enterocytes prepared from guinea pig small intestine was saturable, temperature dependent, and reversible, and reflected interaction of the labeled peptide with a single class of binding sites. Each enterocyte possessed approximately 60,000 binding sites and binding of the tracer
H J, Binder, G F, Lemp, J D, Gardner
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Vasoactive intestinal peptide receptor scintigraphy.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1995
This study presents the biodistribution, safety and absorbed dose of 123I-VIP administered to 18 patients with intestinal adenocarcinomas or endocrine tumors.To achieve high-specific activity, 123I-VIP was purified by HPLC. Following intravenous administration of 123I-VIP (172 +/- 17 MBq (4.65 +/- 0.5 mCi); < 300 pmole ( < 1 microgram)/patient ...
I, Virgolini, A, Kurtaran, M, Raderer, M, Leimer, P, Angelberger, E, Havlik, S, Li, W, Scheithauer, B, Niederle, P, Valent   +9 more
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Characterization of vasoactive intestinal peptide receptors in canine liver membranes

Biochemical Pharmacology, 1994
The binding characteristics of vasoactive intestinal peptide (VIP) in the liver membranes of the dog were examined using radioligand binding assay with 125I-VIP and unlabelled peptides and results were compared with those from the rat. The binding of VIP to canine liver membranes occurred in a reversible, saturable, specific and temperature-dependent ...
T, Kiso, S, Ito, T, Ohta, T, Asano, Y, Nakazato   +4 more
openaire   +2 more sources

Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1986
From structure-activity relationship studies of rat growth hormone-releasing factor (rGFR) on the vasoactive intestinal peptide (VIP) receptor in an in vitro preparation of exocrine pancreas, we predicted that [4Cl-D-Phe6, Leu17]VIP would be a competitive antagonist for the action of VIP.
S J, Pandol, K, Dharmsathaphorn, M S, Schoeffield, W, Vale, J, Rivier   +4 more
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Characterization of Vasoactive Intestinal Peptide (VIP) receptors in mammalian lung

Peptides, 1986
125I-VIP bound specifically to sites on human, rat, guinea pig, and rabbit lung membranes with a dissociation constant (KD) of 60-200 pM and binding site maxima of 200-800 fmol/mg of protein. The presence of a second lower affinity site was detected but not investigated further.
K E, Dickinson, M, Schachter, C M, Miles, D H, Coy, P S, Sever   +4 more
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Receptors for vasoactive intestinal peptide on isolated human sweat glands

Peptides, 1986
Human sweat gland function is predominantly under cholinergic control. Sweat secretion may also be regulated by Vasoactive Intestinal Peptide (VIP), which coexists with acetylcholine in nerves to sweat gland acini and ducts. We have examined the expression of VIP receptors on isolated human eccrine sweat glands.
P, Heinz-Erian, S, Paul, S I, Said
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Vasoactive intestinal peptide receptor antagonists in rat seminal vesicle membranes

European Journal of Pharmacology: Molecular Pharmacology, 1991
Vasoactive intestinal peptide (VIP) receptors coupled to activation of adenylate cyclase have been previously identified in seminal vesicle membranes of rat. In the present study we demonstrate that the synthetic peptides [4-Cl-D-Phe6,Leu17]VIP and the growth hormone releasing factor (GRF) analog [Ac-Tyr1,D-Phe2]GRF1-29-NH2 inhibit in a competitive ...
M S, Rodríguez-Pena, L G, Guijarro, J C, Prieto   +2 more
openaire   +2 more sources

Characterization of vasoactive intestinal peptide receptors in rat seminal vesicle

American Journal of Physiology-Endocrinology and Metabolism, 1991
Receptors for vasoactive intestinal peptide (VIP) in membranes from rat seminal vesicle were examined using 125I-labeled VIP as ligand. The receptor binding was rapid, reversible, saturable, specific, and dependent on temperature and membrane concentration.
L G, Guijarro, M S, Rodriguez-Pena, J C, Prieto   +2 more
openaire   +2 more sources