Vasoactive Intestinal Peptide in Thymus: Synthesis, Receptors and Biological Actions
Neuroimmunomodulation, 1999Evidence summarized in this report indicates that thymocytes produce and secrete VIP. Moreover, different stimuli such as Con A, LPS and anti-TCR antibody induce a significant increase in VIP production by thymocytes. In addition, proinflammatory cytokines such as IL-1, IL-6 and TNF-α, but not IL-2, stimulate in a similar time-dependent manner VIP ...
M, Delgado +3 more
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Characterization of vasoactive intestinal peptide receptors on rat alveolar macrophages
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1994In view of the evidence that vasoactive intestinal peptide (VIP) may modulate acute inflammatory injury in the lung, we investigated the presence and characteristics of VIP receptors on alveolar macrophages (AMs). We examined the binding of monoiodinated [Tyr(125I)10]-labeled VIP (125I-VIP) to rat AMs (> 96% pure), obtained from Sprague-Dawley rats
H, Sakakibara, K, Shima, S I, Said
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The Airway and Vasoactive Intestinal Peptide Autoantibodies and Receptors
2020This chapter outlines observations on human autoantibodies directed against vasoactive intestinal peptide (VIP), the functional properties of these autoantibodies, and their relevance to disease; and characteristics, regulatory features, and signal-transducing pathways utilized by the VIP receptor in guinea pig lung.
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Vasoactive intestinal peptide and its receptors in fetuses with cystic fibrosis
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1989Fetuses were investigated to establish whether vasoactive intestinal peptide (VIP) and its receptors are involved in the basic biochemical defect causing cystic fibrosis (CF). The intestine was used as a target for the disease and the liver as control.
E, Chastre +6 more
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Distribution of vasoactive intestinal peptide and its receptors in the arteries of the rabbit
Journal of Surgical Research, 1989Vasoactive intestinal peptide (VIP) is a widely distributed neurotransmitter whose dilatory effects on vascular smooth muscle are believed to be mediated via specific receptors. To determine the possible role of VIP in regulating specific vascular beds, we examined the relationship between arterial wall VIP content as determined by radioimmunoassay and
A N, Sidawy +6 more
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The vasoactive intestinal peptide (VIP) receptor: recent data and hypothesis
Biochimie, 1988Vasoactive intestinal peptide (VIP) is a neuropeptide with a broad range of biological activities in various tissues. After interaction with its membrane receptor, VIP generally induces a very large increase in the intracellular cyclic AMP level. Receptors for VIP have been described in numerous tissues and cell lines. The first results on VIP receptor
J, Luis +4 more
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Vasoactive intestinal peptide receptor localization in rat forebrain by autoradiography
Neuroscience Letters, 1985Vasoactive intestinal peptide (VIP) receptors were localized in rat forebrain by in vitro labeling light microscopic autoradiography with 125I-labeled VIP. Binding sites for VIP were found in discrete areas of rat forebrain including lamina I of the neocortex and pyriform cortex, caudate-putamen, the hippocampus and molecular layer of the dentate gyrus,
E B, De Souza, H, Seifert, M J, Kuhar
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Ontogeny of vasoactive intestinal peptide receptors in rat ventral prostate
General Pharmacology: The Vascular System, 19941. The stimulatory effect of VIP on rat prostatic adenylyl cyclase changes during postnatal development. It peaks at 2 months (peripubertal period), remains in a plateau between 3 and 12 months (adult period), and decreases at 24 months (old period). 2.
M G, Juarranz +4 more
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Intestinal adenocarcinomas and various endocrine tumors express large numbers of high-affinity receptors for vasoactive intestinal peptide (VIP). We have evaluated the usefulness of scanning with VIP labeled with iodine-123 for tumor localization in patients with gastrointestinal tumors.Radioiodinated VIP was purified by high-pressure liquid ...
I, Virgolini +11 more
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Ontogenic Development of Vasoactive Intestinal Peptide Receptors in Rat Intestinal Cells and Liver*
Endocrinology, 1987Changes in the functional and biochemical characteristics of membrane receptors for vasoactive intestinal peptide (VIP) were evaluated in vitro, using epithelial intestinal cells isolated during rat development, from day 17 of gestation to adulthood.
E, Chastre +3 more
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