Results 61 to 70 of about 12,163 (157)

Immune activation and response dynamics of human iPSC‐derived macrophages in tuberculosis infection models

Clinical &Translational Immunology, Volume 15, Issue 1, 2026.
In this study, we analysed the immune responses of blood‐derived monocyte macrophages and iPSC‐derived macrophages following BCG/HKMT infection. We found that iPSC‐derived macrophages displayed a markedly stronger activation profile, including faster migration, increased reactive oxygen species production, elevated apoptosis marker expression and ...
Daniela Paasch, Hannah Schevel, Andrea Riehle, Bibiana Costa, Hassan Toufaili, Tabea Gehnen, Julia Dahlmann, Andreas Pavlou, Anna‐Lena Neehus, Ariane Hai Ha Nguyen, Erika Schiering, Theresa Buchegger, Jacinta Bustamante, Gesine Hansen, Ulrich Kalinke, Erich Gulbins, Heike Grassmé, Nico Lachmann   +17 more
wiley   +1 more source

Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memory [PDF]

Frontiers in Immunology, 2014
Bacille Calmette-Guérin (BCG), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against active TB in children, BCG has failed to protect adults against TB infection and active disease development, especially in developing countries where the disease is endemic ...
da Costa, Adeliane Castro, Nogueira, Sarah Veloso, Kipnis, André, Junqueira-Kipnis, Ana Paula   +3 more
openaire   +3 more sources

Immune Modulation by Plasmodium yoelii: Insights From Lethal and Non‐Lethal Strains

Parasite Immunology, Volume 48, Issue 1, January 2026.
ABSTRACT Malaria pathogenesis is driven by intricate host–parasite interactions that determine immune balance and clinical outcome. The Plasmodium yoelii model, particularly its lethal (17XL) and non‐lethal (17XNL) strains, provides a robust framework to investigate these dynamics.
Sharoen Yu Ming Lim
wiley   +1 more source

Advances and challenges in recombinant Mycobacterium bovis BCG-based HIV vaccine development: lessons learned

Expert Review of Vaccines, 2018
Introduction: Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome, tuberculosis, and malaria are responsible for most human deaths produced by infectious diseases worldwide.
Athina Kilpeläinen, Milena Maya-Hoyos, Narcís Saubí, Carlos Y. Soto, Joan Joseph   +4 more
doaj   +1 more source

Anticipating Knowledge Applicability in Open Science Through Recycling, Mimicking, and Shortcutting

R&D Management, Volume 56, Issue 1, Page 71-87, January 2026.
ABSTRACT Open science literature scrutinizes how organizations provide access to knowledge. Yet, much less is known about how organizations pursuing open science for societal impact anticipate knowledge applicability—that shared knowledge is reusable for other organizations and individuals, and enables open social innovation.
Konstantin Hondros, Milena Leybold, Leonhard Dobusch, Sigrid Quack   +3 more
wiley   +1 more source

Neutrophil Plasticity and NETosis in Tumour Microenvironment: Tumour Evolution and Therapy Resistance

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Neutrophil extracellular traps (NETs) are web‐like formations consisting of DNA‐histone complexes and associated proteins released from activated neutrophils. While NET formation plays an important role in innate immunity, it is also associated with the pathogenesis of autoimmune disorders such as rheumatoid arthritis, psoriasis and systemic lupus ...
Mojdeh Soltani, Sara Falahi, Mohammad Abbaszadeh, Mark J. M. Sullman, Hamed Fouladseresht, Nahid Eskandari, Poorani Gurumallesh   +6 more
wiley   +1 more source

Trained Immunity Exacerbates Inflammatory Arthritis Progression via Promoting Synovial Fibroblast Ferroptotic Resistance

Advanced Science, Volume 12, Issue 46, December 11, 2025.
β‐glucan‐induced trained immunity reprograms macrophages toward hyperinflammation, exacerbating inflammatory arthritis. In a collagen‐induced arthritis model, trained macrophages intensify disease severity and confer ferroptosis resistance in synovial cells via IL‐1β/NAT10‐mediated FSP1 mRNA modification.
Haibo Su, Baoying Zhang, Qiudi Deng, Jiaxin Huang, Jinyu Feng, Yuan Fu, Yuejun Huang, Weikun Deng, YingJun Su, Huisheng Liu, Ning‐yi Shao, Zhenhui Zhang, Jianwei Dai   +12 more
wiley   +1 more source

Recombinant BCG as a vaccine vehicle to protect against tuberculosis [PDF]

Bioengineered Bugs, 2010
Mycobacterium bovis Bacille Calmette Guérin (BCG) was first administered to humans in 1921 and has subsequently been delivered to an estimated 3 billion individuals, with a low incidence of serious complications. The vaccine is immunogenic and is stable and cheap to produce.
openaire   +2 more sources

Th1 Cytokine-Secreting Recombinant Mycobacterium bovis Bacillus Calmette-Guérin and Prospective Use in Immunotherapy of Bladder Cancer

Clinical and Developmental Immunology, 2011
Intravesical instillation of Mycobacterium bovis bacillus Calmette-Guérin (BCG) has been used for treating bladder cancer for 3 decades. However, BCG therapy is ineffective in approximately 30–40% of cases.
Yi Luo, Jonathan Henning, Michael A. O'Donnell   +2 more
doaj   +1 more source

BCG-induced trained immunity: history, mechanisms and potential applications

Journal of Translational Medicine, 2023
The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the prevention of tuberculosis, but also has a non-specific protective effect on the human body called trained ...
Jingjing Chen, Li Gao, Xinya Wu, Yuxin Fan, Meixiao Liu, Li Peng, Jieqin Song, Bingxue Li, Aihua Liu, Fukai Bao   +9 more
doaj   +1 more source