Results 141 to 150 of about 520,105 (221)

Myelin Maintenance and Addition Regulate Synaptic Plasticity in the Adult Mouse Cortex

Glia, Volume 74, Issue 12, December 2026.
We report that existing myelin allows neurons to remain plastic throughout life, while new myelin progressively stabilises synapses along the basal but not apical dendrites of layer V pyramidal neurons in the motor cortex. ABSTRACT Myelin has the capacity to affect synapse number or plasticity across the lifespan.
Renee E. Pepper, Kalina Makowiecki, Kimberley A. Pitman, Raphael Ricci, Angela L. Nicoli, Phuong Tram Nguyen, Catherine A. Blizzard, Ben Emery, Carlie L. Cullen, Kaylene M. Young   +9 more
wiley   +1 more source

Adolescent Ethanol Exposure Disrupts the Mature Phenotype of Surviving Neuroprogenitors in Female Mice

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT Rodent models of human adolescent binge drinking persistently reduce adult neurogenesis and induce innate immune signaling cascades, suggesting long‐lasting dysfunction in the hippocampal neurogenic niche. Nevertheless, many neuroprogenitors survive, and the impact of adolescent ethanol on the mature phenotype of these surviving neurons is ...
Kaitlyn Campbell, Madison McDowell, Eymani Alston, Hunter Kelley, Michael Kasten, Paul B. Manis, Fulton Crews, Victoria Macht   +7 more
wiley   +1 more source

Paratuberculosis in small ruminants in the Sudan: prevalence and risk factors

BMC Veterinary Research
Background Paratuberculosis (PTB), caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a contagious and chronic enteric disease of ruminants and many non-ruminants leading to emaciation and death of the animal.
Sanaa M. Idris, Wisal A. Elmagzoub, Julius B. Okuni, Lonzy Ojok, Mohamed E. Mukhtar, Enass M. Abdalla, Sulieman M. El Sanousi, Ahmad Amanzada, Uwe Truyen, Ahmed Abd El Wahed, ElSagad Eltayeb, Kamal H. Eltom, Ahmed A. Gameel   +12 more
doaj   +1 more source

A YAP–TEAD–CTCF Transcriptional Regulatory Axis Associated With the Elimination of Injured Hepatocytes From the Liver

Genes to Cells, Volume 31, Issue 6, November 2026.
Injured YAP‐activated hepatocytes are eliminated from the liver. They are extruded toward the sinusoidal lumen, undergo cell death, and are phagocytosed by macrophages. Here, we performed proximity ligation assay, ATAC‐seq, RNA‐seq, and CellChat analyses.
Daiki Hatakeyama, Yoshimi Okamoto‐Uchida, Misaki Kosaka, Haruka Hirose, Satoshi Kofuji, Keiko Danzaki, Yoshiki Endo, Michiko Nakagawa, Akinori Kanai, Yutaka Suzuki, Takeshi Yokoo, Shuji Terai, Teppei Shimamura, Hiroshi Nishina   +13 more
wiley   +1 more source

Allele‐Specific GNAQ Q209 Mutations Reveal Context‐Dependent Oncogenic Programs in Uveal Melanoma

Pigment Cell &Melanoma Research, Volume 39, Issue 6, November 2026.
Using matched immune‐competent, multistep uveal melanoma models, we show that GNAQ Q209L and Q209R mutations are not functionally equivalent. Q209L drives faster in vivo progression but reduces in vitro proliferation and migration, whereas Q209R promotes greater in vitro fitness and preferential FAK‐YAP activation, revealing an allele‐dependent ...
Vinesh Jarajapu, Sathya Neelature Sriramareddy, Nicol Mecozzi, Kaizhen Wang, Florian A. Karreth, Xiaonan Xu   +5 more
wiley   +1 more source

Ten‐Eleven Translocation Enzymes Control the Rate and Mode of Retinal Progenitor Cell Division in the Developing Retina

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Early RPCs divide predominantly symmetrically and exhibit a high proliferation rate, resulting in rapid retinal growth. Late RPCs divide predominantly asymmetrically and exhibit a low proliferation rate. Our results suggest that TET‐deficient RPCs divide predominantly asymmetrically but exhibit a high proliferation rate.
Galina Dvoriantchikova, Michelle Fleishaker, Byron L. Lam, Dmitry Ivanov   +3 more
wiley   +1 more source

Advances in CRISPR‐based detection technologies for severe fever with thrombocytopenia syndrome virus (Dabiebanda virus): A mini review

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review summarises the detection methods for severe fever with thrombocytopenia syndrome virus based on CRISPR platforms. (A) CRISPR with fluorescent reporter. (B) CRISPR with lateral flow test strip. (C) CRISPR with DNAzyme. (D) Digital CRISPR. (E) CRISPR with single micro‐ring resonator biosensor. (F) self‐amplifying signal amplification strategy
Junhu Wang, Changqiang Zhu, Jinzhao Chu, Yingqing Mao, Yixin Ge, Haiming Yi, Hongming Wang, Yuexi Li, Yong Qi   +8 more
wiley   +1 more source

Müller Glia–Vasculature Interactions in the Developing Retina

Glia, Volume 74, Issue 10, October 2026.
Retinal vascular layers form normally despite loss of cholinergic retinal waves. Müller glial processes contact endothelial tip cells early and form Aquaporin‐4‐enriched endfeet. Glial endfoot calcium signals are compartmentalized and occur largely independently of neural activity. ABSTRACT Coordinated signaling among neurons, glia, and the vasculature
Samira Monshietehadi, Angel J. Garcia, Benjamin E. Smith, Matthew Tarchick, Kiara Abhayaratne, Aileen Conley, Marla B. Feller   +6 more
wiley   +1 more source

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions

Glia, Volume 74, Issue 10, October 2026.
CX3CR1 deficiency promotes microglial migration toward CNS injury. Proteomic profiling reveals altered RHO‐mediated cytoskeletal signaling, while in vivo two‐photon imaging demonstrates increased process extension, velocity, and accumulation of Cx3cr1‐deficient microglia at lesion sites. ABSTRACT Microglia are innate immune cells of the central nervous
Jens Wagner, Henrike Antony, Cornelia Hoyer, Kristiina Lundgrén, Rabah Soliymani, Sophie Crux, Lena Justus, Kevin Keppler, Julia Steffen, Christian Kurts, Daniel R. Engel, Jochen Herms, Maciej Łałowski, Martin Fuhrmann   +13 more
wiley   +1 more source

Establishment of Salivary Gland Tumors Arising in Salivary Gland‐Specific EWSR1::ATF1 Transgenic Mice

Head &Neck, Volume 48, Issue 10, Page 2733-2744, October 2026.
ABSTRACT Background Salivary gland carcinomas are uncommon malignancies with various histological subtypes harboring fusion genes. The EWSR1::ATF1 fusion gene, resulting from a translocation between chromosomes 12 and 22, is frequently observed in hyalinizing clear cell carcinoma (HCCC). However, the role of this fusion gene in HCCC oncogenesis remains
Yuri Hirai, Yoshitaka Utsumi, Daisuke Sano, Tatsu Kuwahara, Yoshihiro Aizawa, Takashi Hatano, Hisashi Hasumi, Yutaro Soejima, Tatsukata Kawagoe, Ryosuke Jikuya, Nobuhisa Mizuki, Satoshi Fujii, Toshitaka Nagao, Nobuhiko Oridate   +13 more
wiley   +1 more source