Results 11 to 20 of about 14,888 (293)
Archaeal tyrosine recombinases [PDF]
FEMS Microbiology Reviews, 2021 ABSTRACTThe integration of mobile genetic elements into their host chromosome influences the immediate fate of cellular organisms and gradually shapes their evolution. Site-specific recombinases catalyzing this integration have been extensively characterized both in bacteria and eukarya.
Catherine Badel +2 more
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Gene stacking by recombinases [PDF]
Plant Biotechnology Journal, 2015 SummaryEfficient methods of stacking genes into plant genomes are needed to expedite transfer of multigenic traits to crop varieties of diverse ecosystems. Over two decades of research has identified several DNA recombinases that carryout efficient cis and trans recombination between the recombination sites artificially introduced into the plant ...
Vibha, Srivastava, James, Thomson
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RAG: a recombinase diversified [PDF]
Nature Immunology, 2009 During B cell and T cell development, the lymphoid-specific proteins RAG-1 and RAG-2 act together to initiate the assembly of antigen receptor genes through a series of site-specific somatic DNA rearrangements that are collectively called variable-diversity-joining (V(D)J) recombination.
Adam G W, Matthews +1 more
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Manipulating or superseding host recombination functions: a dilemma that shapes phage evolvability. [PDF]
PLoS Genetics, 2013 Phages, like many parasites, tend to have small genomes and may encode autonomous functions or manipulate those of their hosts'. Recombination functions are essential for phage replication and diversification. They are also nearly ubiquitous in bacteria.
Louis-Marie Bobay +2 more
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mSphere, 2019 Most urinary tract infections (UTIs) are caused by uropathogenic Escherichia coli (UPEC), which depends on an extracellular organelle (type 1 pili) for adherence to bladder cells during infection.
Colin W. Russell +6 more
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BRCA2: a universal recombinase regulator [PDF]
Oncogene, 2007 Homologous recombination has a dual role in eukaryotic organisms. Firstly, it is responsible for the creation of genetic variability during meiosis by directing the formation of reciprocal crossovers that result in random combinations of alleles and traits.
T, Thorslund, S C, West
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Cell Reports, 2020 Summary: Meiotic recombination is critical for genetic exchange and generation of chiasmata that ensures faithful chromosome segregation during meiosis I.
Kazumasa Takemoto +9 more
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The emerging role of recombineering in microbiology
Engineering Microbiology, 2023 : Recombineering is a valuable technique for generating recombinant DNA in vivo, primarily in bacterial cells, and is based on homologous recombination using phage-encoded homologous recombinases, such as Redαβγ from the lambda phage and RecET from the ...
Ruijuan Li +3 more
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Modeling Gliomas Using Two Recombinases [PDF]
Cancer Research, 2019 Abstract Development of animal models to investigate the complex ecosystem of malignant gliomas using the Cre/loxP recombination system has significantly contributed to our understanding of the molecular underpinnings of this deadly disease.
Toshiro Hara, Inder M. Verma
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Plant DNA Recombinases: A Long Way to Go
Journal of Nucleic Acids, 2010 DNA homologous recombination is fundamental process by which two homologous DNA molecules exchange the genetic information for the generation of genetic diversity and maintain the genomic integrity.
Rajani Kant Chittela +1 more
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