Results 21 to 30 of about 10,769 (161)
Cell Reports, 2020 Summary: Meiotic recombination is critical for genetic exchange and generation of chiasmata that ensures faithful chromosome segregation during meiosis I.
Kazumasa Takemoto +9 more
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The emerging role of recombineering in microbiology
Engineering Microbiology, 2023 : Recombineering is a valuable technique for generating recombinant DNA in vivo, primarily in bacterial cells, and is based on homologous recombination using phage-encoded homologous recombinases, such as Redαβγ from the lambda phage and RecET from the ...
Ruijuan Li +3 more
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Plant DNA Recombinases: A Long Way to Go
Journal of Nucleic Acids, 2010 DNA homologous recombination is fundamental process by which two homologous DNA molecules exchange the genetic information for the generation of genetic diversity and maintain the genomic integrity.
Rajani Kant Chittela +1 more
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The dif/Xer recombination systems in proteobacteria. [PDF]
PLoS ONE, 2009 In E. coli, 10 to 15% of growing bacteria produce dimeric chromosomes during DNA replication. These dimers are resolved by XerC and XerD, two tyrosine recombinases that target the 28-nucleotide motif (dif) associated with the chromosome's replication ...
Christophe Carnoy, Claude-Alain Roten
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RUNX1 as a recombinase cofactor
Oncotarget, 2015 The regulation of TCR rearrangements, particularly of TCRδ and TCRβ, plays a decisive role in lymphoid differentiation and oncogenic transformation. Somatic assembly of TCR loci is established through V(D)J recombination during lymphocyte development.
Agata, Cieslak +2 more
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High-performance chemical- and light-inducible recombinases in mammalian cells and mice
Nature Communications, 2019 The availability of high performance recombinases with low basal activity and high dynamic range is limited. Here the authors present a library of over 20 orthogonal split recombinases that can be induced by small molecules, light and temperature in vivo.
Benjamin H. Weinberg +13 more
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High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases
Nature Communications, 2019 The development of site-specific recombinases as genome editing tools is limited by the difficulty of altering their DNA sequence specificity. Here the authors present Rec-seq, a method for identifying specificity determinants and off-target substrates ...
Jeffrey L. Bessen +7 more
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mBio, 2018 Uropathogenic Escherichia coli (UPEC) is the most common etiologic agent of uncomplicated urinary tract infection (UTI). An important mechanism of gene regulation in UPEC is phase variation that involves inversion of a promoter-containing DNA element via
E. J. Battaglioli +5 more
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Nature Communications, 2019 Homology directed repair of meiotic double-strand breaks functions via recruitment and assembly of strand-exchange proteins called recombinases. Here the authors reveal and characterize a BRCA2 interactor regulating meiotic recombinases that localizes to
Jingjing Zhang +3 more
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The Rad52 SSAP superfamily and new insight into homologous recombination
Communications Biology, 2023 Recent structures of DNA-bound bacterial and phage recombinases provide insights into homologous recombination and suggest relation to the eukaryotic Rad52 and identification of a Rad52 single strand annealing protein (SSAP) superfamily.
Ali Al-Fatlawi +2 more
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