Results 21 to 30 of about 12,788 (278)
Determinants of selectivity in Xer site-specific recombination [PDF]
, 1996 A remarkable property of some DNA-binding proteins that can interact with and pair distant DNA segments is that they mediate their biological function only when their binding sites are arranged in a specific configuration. Xer site-specific recombination
Blakely, G, Sherratt, D
core +1 more source
RAG: a recombinase diversified [PDF]
Nature Immunology, 2009 During B cell and T cell development, the lymphoid-specific proteins RAG-1 and RAG-2 act together to initiate the assembly of antigen receptor genes through a series of site-specific somatic DNA rearrangements that are collectively called variable-diversity-joining (V(D)J) recombination.
Adam G W, Matthews +1 more
openaire +2 more sources
Cell Reports, 2020 Summary: Meiotic recombination is critical for genetic exchange and generation of chiasmata that ensures faithful chromosome segregation during meiosis I.
Kazumasa Takemoto +9 more
doaj +1 more source
Manipulating or superseding host recombination functions: a dilemma that shapes phage evolvability. [PDF]
PLoS Genetics, 2013 Phages, like many parasites, tend to have small genomes and may encode autonomous functions or manipulate those of their hosts'. Recombination functions are essential for phage replication and diversification. They are also nearly ubiquitous in bacteria.
Louis-Marie Bobay +2 more
doaj +1 more source
mSphere, 2019 Most urinary tract infections (UTIs) are caused by uropathogenic Escherichia coli (UPEC), which depends on an extracellular organelle (type 1 pili) for adherence to bladder cells during infection.
Colin W. Russell +6 more
doaj +1 more source
Structure, function, and applications of two novel phage recombinases from extreme environments. [PDF]
Nucleic Acids ResThis study describes the identification and characterization of two new extremophilic phage recombinases, UvsXt and UvsXp, discovered through metagenomic analysis within the Virus-X project, and explores their potential applications in biotechnology. DNA
Tarrant E +13 more
europepmc +2 more sources
The emerging role of recombineering in microbiology
Engineering Microbiology, 2023 : Recombineering is a valuable technique for generating recombinant DNA in vivo, primarily in bacterial cells, and is based on homologous recombination using phage-encoded homologous recombinases, such as Redαβγ from the lambda phage and RecET from the ...
Ruijuan Li +3 more
doaj +1 more source
The dif/Xer recombination systems in proteobacteria. [PDF]
PLoS ONE, 2009 In E. coli, 10 to 15% of growing bacteria produce dimeric chromosomes during DNA replication. These dimers are resolved by XerC and XerD, two tyrosine recombinases that target the 28-nucleotide motif (dif) associated with the chromosome's replication ...
Christophe Carnoy, Claude-Alain Roten
doaj +1 more source
RUNX1 as a recombinase cofactor
Oncotarget, 2015 The regulation of TCR rearrangements, particularly of TCRδ and TCRβ, plays a decisive role in lymphoid differentiation and oncogenic transformation. Somatic assembly of TCR loci is established through V(D)J recombination during lymphocyte development.
Agata, Cieslak +2 more
openaire +2 more sources
Light-Inducible Recombinases for Bacterial Optogenetics
, 2020 Optogenetic tools can provide direct and programmable control of gene expression. Light-inducible recombinases, in particular, offer a powerful method for achieving precise spatiotemporal control of DNA modification.
Michael B. Sheets (8338722) +2 more
core +1 more source