Results 11 to 20 of about 10,769 (161)
Site‐specific recombinase genome engineering toolkit in maize
Plant Direct, 2020 Site‐specific recombinase enzymes function in heterologous cellular environments to initiate strand‐switching reactions between unique DNA sequences termed recombinase binding sites. Depending on binding site position and orientation, reactions result in
Jon P. Cody +4 more
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Archaeal tyrosine recombinases
FEMS Microbiology Reviews, 2021 ABSTRACTThe integration of mobile genetic elements into their host chromosome influences the immediate fate of cellular organisms and gradually shapes their evolution. Site-specific recombinases catalyzing this integration have been extensively characterized both in bacteria and eukarya.
Badel, Catherine +2 more
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Gene stacking by recombinases [PDF]
Plant Biotechnology Journal, 2015 SummaryEfficient methods of stacking genes into plant genomes are needed to expedite transfer of multigenic traits to crop varieties of diverse ecosystems. Over two decades of research has identified several DNA recombinases that carryout efficient cis and trans recombination between the recombination sites artificially introduced into the plant ...
Vibha, Srivastava, James, Thomson
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Stimulation of homologous recombination in plants expressing heterologous recombinases
BMC Plant Biology, 2020 Background Current excitement about the opportunities for gene editing in plants have been prompted by advances in CRISPR/Cas and TALEN technologies. CRISPR/Cas is widely used to knock-out or modify genes by inducing targeted double-strand breaks (DSBs ...
Abdellah Barakate +3 more
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Molecules, 2023 RecA family recombinases are the core enzymes in the process of homologous recombination, and their normal operation ensures the stability of the genome and the healthy development of organisms.
Yue Pan +4 more
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Frontiers in Neuroanatomy, 2017 Central noradrenergic neurons, collectively defined by synthesis of the neurotransmitter norepinephrine, are a diverse collection of cells in the hindbrain, differing in their anatomy, physiological and behavioral functions, and susceptibility to disease
Nicholas W. Plummer +4 more
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RAG: a recombinase diversified [PDF]
Nature Immunology, 2009 During B cell and T cell development, the lymphoid-specific proteins RAG-1 and RAG-2 act together to initiate the assembly of antigen receptor genes through a series of site-specific somatic DNA rearrangements that are collectively called variable-diversity-joining (V(D)J) recombination.
Adam G W, Matthews +1 more
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Manipulating or superseding host recombination functions: a dilemma that shapes phage evolvability. [PDF]
PLoS Genetics, 2013 Phages, like many parasites, tend to have small genomes and may encode autonomous functions or manipulate those of their hosts'. Recombination functions are essential for phage replication and diversification. They are also nearly ubiquitous in bacteria.
Louis-Marie Bobay +2 more
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Diversity in the serine recombinases [PDF]
Molecular Microbiology, 2002 SummaryMost site‐specific recombinases fall into one of two families, based on evolutionary and mechanistic relatedness. These are the tyrosine recombinases orλintegrase family and the serine recombinases or resolvase/invertase family. The tyrosine recombinases are structurally diverse and functionally versatile and include integrases, resolvases ...
Margaret C M, Smith, Helena M, Thorpe
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mSphere, 2019 Most urinary tract infections (UTIs) are caused by uropathogenic Escherichia coli (UPEC), which depends on an extracellular organelle (type 1 pili) for adherence to bladder cells during infection.
Colin W. Russell +6 more
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