Results 201 to 210 of about 17,679 (284)

Conversion of a telomere resolvase into a Cre-like site-specific recombinase. [PDF]

PLoS One
Huang SH, Balouchi M, Kobryn K.
europepmc   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

IME_Rho_tet, a novel family of putative integrative mobilizable elements spreading tetracycline resistance genes <i>tet</i>(W) and <i>tet</i>(32) among human and animal gut bacteria. [PDF]

Microb Genom
Sidibé O, Doublet B, Leclercq SO.
europepmc   +1 more source

Robust activity‐dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation

The Journal of Physiology, EarlyView.
Abstract figure legend In cortical layer (L)5 pyramidal neurons we found that mitochondria in the axon initial segment (AIS) are distributed non‐uniformly and display robust calcium (Ca2+) uptake during action potential (AP) firing. Because the AIS is the site for the initiation of APs, which are shaped by cytosolic Ca2+ levels, we hypothesized that ...
Koen Kole, Maarten H.P. Kole
wiley   +1 more source

Recent advances in site-specific transgene insertion into the maize genome using recombinases and genome editing endonucleases. [PDF]

Front Plant Sci
Basso MF, Pinto MS, Nonato JVA, Dante RA, Yassitepe JECT.   +4 more
europepmc   +1 more source

Conflicting adaptations in an inhibitory feedback circuit

The Journal of Physiology, EarlyView.
Abstract figure legend We studied activity‐dependent adaptation in the fruit fly Drosophila’s memory centre, the mushroom body. Here, excitatory Kenyon cells (KCs) receive feedback inhibition from the anterior paired lateral (APL) neuron. When KCs are artificially overactivated for 24 h, both KCs and APL reduce their sensitivity to excitation (‘↓ Exc’,
Gregor A. Bergmann, Melissa W. Tan, Katie Greenin‐Whitehead, Philippe J. Fischer, Thomas C. Cozens, Andrew C. Lin   +5 more
wiley   +1 more source

A powerful and highly efficient PAI-mediated transgenesis approach in Drosophila. [PDF]

Nucleic Acids Res
Shi W, Zhang X, Sun A, Zheng J, Zhuang K, Chen Z, Peng J, Fu P, Gao G.   +8 more
europepmc   +1 more source

Synaptic Potentiation in Hippocampus by eEF2K Inhibitor A484954

Hippocampus, Volume 36, Issue 3, May 2026.
ABSTRACT An important mechanism controlling protein synthesis is through phosphorylation of the eukaryotic elongation factor 2 (eEF2) by its kinase eEF2K. Hyperphosphorylation of eEF2 is linked to many neuronal diseases characterized by cognitive impairments.
Qian Yang, Tian Li, Hannah M. Jester, Qiang Su, Xueyan Zhou, Alexey G. Ryazanov, Tao Ma   +6 more
wiley   +1 more source

FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells. [PDF]

J Exp Med
Farré Díaz C, Kabrani E, Winkler W, Blanc E, Wollert-Wulf B, Salomon C, Wunderlich FT, Beule D, Janz M, Rajewsky K.   +9 more
europepmc   +1 more source

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview

American Journal of Hematology, Volume 101, Issue S1, Page 56-74, April 2026.
ABSTRACT The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs.
Adetola A. Kassim, Alexis A. Thompson, Punam Malik   +2 more
wiley   +1 more source