Results 211 to 220 of about 17,679 (284)

Generation of a Novel Col8a2P2A‐CreERT2 Mouse Line Enables Targeted Genetic Manipulation of Corneal Endothelial Cells and Modeling of Endothelial Decompensation

open access: yesgenesis, Volume 64, Issue 2, April 2026.
ABSTRACT The corneal endothelium is a monolayer of specialized cells that maintains stromal deturgescence and transparency, functions essential for vision. Despite its clinical importance, the developmental origins and homeostatic programs of the endothelium remain poorly understood, in part due to the lack of a lineage‐specific genetic driver.
Yong Yuan   +9 more
wiley   +1 more source

C/EBP α is Essential for Gonadal but Not Inguinal White Adipose Tissue Formation in Mice

open access: yesObesity, Volume 34, Issue 4, Page 882-895, April 2026.
Human genetics has linked the gene CEBPA to waist to hip ratio and adipose distribution. We generated mice with AdipoQ‐Cre driven deletion of Cebpa and found these mice to have a specific reduction in gonadal white adipose tissue and myriad other metabolic phenotypes.
Krista Y. Hu   +10 more
wiley   +1 more source

Development and Laboratory Validation of a Field‐Deployable CRISPR‐Cas12a eDNA Assay for Phylogeographic Lineage Detection in Arctic Char (Salvelinus alpinus)

open access: yesMolecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT Environmental DNA (eDNA) tools are increasingly used for biodiversity monitoring, with most existing assays targeting species‐level identification. However, the use of eDNA to resolve intraspecific genetic variation remains rare and methodologically underdeveloped.
Darren J. Walsh   +5 more
wiley   +1 more source

Unraveling the Genetic Mysteries of Müllerian Anomalies: Research Approaches and Clinical Significance

open access: yesClinical Genetics, Volume 109, Issue 4, Page 615-629, April 2026.
This review primarily summarizes the genetic defects in Müllerian anomalies, the tools used to validate these genetic defects, and the future clinical significance of identifying the precise genetic etiology of Müllerian anomalies. ABSTRACT Müllerian anomalies are a collection of heterogeneous anatomical disorders of the female genital tract that ...
Jingfang Li   +5 more
wiley   +1 more source

Characterization of Social and Repetitive Behaviors of Mllt11/Af1q/TcF7c Conditional Knockout Mice

open access: yesEuropean Journal of Neuroscience, Volume 63, Issue 7, April 2026.
Sex‐specific neurodevelopmental defects in Mllt11 conditional knockout mice. Females displayed reduced social interest, increased freezing, and decreased nestlet shredding, while males exhibited increased novelty‐seeking behaviors. ABSTRACT Mllt11 (myeloid/lymphoid or mixed‐lineage leukemia translocated to chromosome 11; also known as Af1q/TcF7c) has ...
Emily A. Witt   +4 more
wiley   +1 more source

Repeated Stress Escalates Aggression and Activity in Fronto‐Limbic Regions in Cntnap2−/− Mice

open access: yesGenes, Brain and Behavior, Volume 25, Issue 2, April 2026.
Stress induced aggression emerges only after repeated restraint stress in Cntnap2−/− mice. Neuronal activity mapping revealed stress‐evoked activation in the lateral septum, lateral habenula, lateral hypothalamus, nucleus accumbens, and prefrontal cortex, with aggressive behavior positively correlating specifically with activity in the lateral septum ...
Caroline H. Hertweck   +7 more
wiley   +1 more source

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