Results 41 to 50 of about 140,429 (262)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Wound Care with Grape Skin Extract and Sustainable Materials: Evidence from an In Vivo Rat Model

Future Pharmacology
Background: This study investigates a novel alginate–gelatin hydrogel incorporating polyphenol-rich grape skin extract as a multifunctional therapeutic system for diabetic wound healing.
Marko Simic, Aleksandar Kocovic, Anica Petrovic, Jovana Joksimovic Jovic, Tijana Markovic, Sandra Jovičić Milić, Vladimir Jakovljevic, Jovana Bradic   +7 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

The Hidden Notes of Redox Balance in Neurodegenerative Diseases

Antioxidants, 2022
Reactive oxygen species (ROS) are versatile molecules that, even if produced in the background of many biological processes and responses, possess pleiotropic roles categorized in two interactive yet opposite domains. In particular, ROS can either function as signaling molecules that shape physiological cell functions, or act as deleterious end ...
Silvia Piccirillo, Simona Magi, Alessandra Preziuso, Tiziano Serfilippi, Giorgia Cerqueni, Monia Orciani, Salvatore Amoroso, Vincenzo Lariccia   +7 more
openaire   +3 more sources

Oral Gel Formulation of Cotinus coggygria Scop. Stem Bark Extract: Development, Characterization, and Therapeutic Efficacy in a Rat Model of Aphthous Stomatitis

Pharmaceutics
Background/Objectives: Encouraged by the traditional use of Cotinus coggygria Scop. (European smoketree) for its anti-inflammatory and antioxidant properties, and considering the limitations of current therapies for recurrent aphthous stomatitis (RAS ...
Jovana Bradic, Miona Vuletic, Vladimir Jakovljevic, Jasmina Sretenovic, Suzana Zivanovic, Marina Tomovic, Jelena Zivkovic, Aleksandar Kocovic, Nina Dragicevic   +8 more
doaj   +1 more source

Oxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome

Neurobiology of Disease, 2012
Rett syndrome is an X chromosome-linked neurodevelopmental disorder associated with cognitive impairment, motor dysfunction and breathing irregularities causing intermittent hypoxia. Evidence for impaired mitochondrial function is also accumulating.
Emanuel Großer, Ursula Hirt, Oliwia A. Janc, Christiane Menzfeld, Marc Fischer, Belinda Kempkes, Steffen Vogelgesang, Till U. Manzke, Lennart Opitz, Gabriela Salinas-Riester, Michael Müller   +10 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Balancing of Ocean Acidification by Superoxide Redox Chemistry? [PDF]

Environmental Science & Technology, 2013
O acidification is typically caused by production of carbonic acid (H2CO3) through the dissolution of increasing atmospheric CO2, which adds to CO2 plus DIC (dissolved CO2, H2CO3, HCO3 −, and CO3 2−) produced in seawater by several processes including biological ones (primary production followed by respiration).
Khan M G, Mostofa, Cong-qiang, Liu, Marco, Minella, Davide, Vione   +3 more
openaire   +2 more sources

Comparative Cardioprotective Effectiveness: NOACs vs. Nattokinase—Bridging Basic Research to Clinical Findings

Biomolecules
The use of non-vitamin K antagonist oral anticoagulants (NOACs) has brought a significant progress in the management of cardiovascular diseases, considered clinically superior to vitamin K antagonists (VKAs) particularly in the prevention and treatment ...
Maja Muric, Marina Nikolic, Andreja Todorovic, Vladimir Jakovljevic, Ksenija Vucicevic   +4 more
doaj   +1 more source