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Redox Regulation of Cellular Signalling
Cellular Signalling, 1999Extracellular stimuli elicit a variety of responses, such as cell proliferation and differentiation, through the cellular signalling system. Binding of growth factors to the respective receptor leads to the activation of receptor tyrosine kinases, which in turn stimulate downstream signalling systems such as mitogen-activated protein (MAP) kinases ...
H, Kamata, H, Hirata
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Quantitative measures for redox signaling
Free Radical Biology and Medicine, 2016Redox signaling is now recognized as an important regulatory mechanism for a number of cellular processes including the antioxidant response, phosphokinase signal transduction and redox metabolism. While there has been considerable progress in identifying the cellular machinery involved in redox signaling, quantitative measures of redox signals have ...
Ché S, Pillay +3 more
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Redox-signals and macrophage biology
Molecular Aspects of Medicine, 2018Macrophages are known for their versatile role in biology. They sense and clear structures that contain exogenous or endogenous pathogen-associated molecular patterns. This process is tightly linked to the production of a mixture of potentially harmful oxidants and cytokines.
Andreas, Weigert +4 more
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The Role of Redox in Signal Transduction
2008It is the functioning of efficient cell signaling which is vital for the survival of cells, whether it is a simple prokaryote or a complex eukaryote, including both animals and plants. Over many years various components have been identified and recognized as crucial for the transduction of signals in cells, including small organic molecules and ions ...
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Redox regulation of TNF signaling
BioFactors, 1999AbstractTNF is produced during inflammation and induces, among other activities, cell death in sensitive tumour cells. We previously reported an increased generation of ROS in TNF‐treated L929 fibrosarcoma cells prior to cell death. These ROS are of mitochondrial origin and participate in the cell death process.
V, Goossens +7 more
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Redox Signaling, Neuroinflammation, and Neurodegeneration
Antioxidants & Redox Signaling, 2018Production of pro-inflammatory and anti-inflammatory cytokines is part of the defense system that mostly microglia and macrophages display to induce normal signaling to counteract the deleterious actions of invading pathogens in the brain. Also, redox activity in the central nervous system (CNS) constitutes an integral part of the metabolic processes ...
Gabriela, Aguilera +4 more
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Sphingolipid signaling and redox regulation
Free Radical Biology and Medicine, 2006Sphingolipids including ceramide and its derivatives such as ceramide-1-phosphate, glycosyl-ceramide, and sphinogosine (-1-phosphate) are now recognized as novel intracellular signal mediators for regulation of inflammation, apoptosis, proliferation, and differentiation.
Je-Seong, Won, Inderjit, Singh
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Redox Signaling in the Right Ventricle
2017Pulmonary hypertension is a devastating disease without cure. The major cause of death among patients with pulmonary hypertension is right heart failure; however, biology of the right heart is not well understood. This lack of knowledge interferes with developing effective therapeutic strategies to treat these patients.
Yuichiro J, Suzuki, Nataliia V, Shults
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Redox metabolism: ROS as specific molecular regulators of cell signaling and function
Molecular Cell, 2021Helena M Cochemé
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