Xenopus reduced folate carrier regulates neural crest development epigenetically. [PDF]
PLoS ONE, 2011 Folic acid deficiency during pregnancy causes birth neurocristopathic malformations resulting from aberrant development of neural crest cells. The Reduced folate carrier (RFC) is a membrane-bound receptor for facilitating transfer of reduced folate into ...
Jiejing Li +4 more
doaj +6 more sources
Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity [PDF]
Fluids and Barriers of the CNS, 2023 Background Reduced folate carrier 1 (RFC1; SLC19a1) is the main responsible transporter for the B9 family of vitamins named folates, which are essential for normal tissue growth and development.
Gokce Gurler +6 more
doaj +3 more sources
Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance Folates are critical for brain development and function. Abnormalities in brain folate transport have been implicated in a number of childhood neurodevelopmental disorders, including cerebral folate deficiency syndrome, hereditary folate ...
Alam C +7 more
europepmc +5 more sources
The role of folate receptor and reduced folate carrier polymorphisms in osteoporosis development [PDF]
Herba Polonica, 2019 Introduction: Osteoporosis is a chronic metabolic disease with multifactorial etiology. One of possible osteoporosis causes may be impairment of osteoclasts function which leads to increased bone resorption. This may be a result of many metabolic changes.
Mrozikiewicz Aleksandra E. +5 more
doaj +3 more sources
Association of reduced folate carrier-1 (RFC-1) polymorphisms with ischemic stroke and silent brain infarction. [PDF]
PLoS ONE, 2015 Stroke is the second leading cause of death in the world and in South Korea. Ischemic stroke and silent brain infarction (SBI) are complex, multifactorial diseases influenced by multiple genetic and environmental factors.
Yunkyung Cho +9 more
doaj +3 more sources
The study of association between reduced folate carrier 1 (RFC1) polymorphism and non-syndromic cleft lip/palate in Iranian population [PDF]
BioImpacts, 2017 Introduction: Cleft lip/palate is one of the most common congenital defects and is supposed to have multifactorial etiology, including a complex interaction between genetics and environment.
Behnoosh Soghani +5 more
doaj +3 more sources
Subcellular localization and distribution of the reduced folate carrier in normal rat tissues [PDF]
European Journal of Histochemistry, 2011 The reduced folate carrier (Rfc1; Slc19a1) mediated transport of reduced folates and antifolate drugs such as methotrexate (MTX) play an essential role in physiological folate homeostasis and MTX cancer chemotherapy.
M. Hinken +3 more
doaj +3 more sources
Animal, 2013 Folate transporters, including the reduced folate carrier and the proton-coupled folate transporter, encoded by Slc19a1 and Slc46a1 genes respectively, play important roles in the transport of folate across biological membranes given the hydrophilic ...
M. Jing, G.B. Tactacan, J.D. House
doaj +4 more sources
The Roles of Reduced Folate Carrier-1 (RFC1) A80G (rs1051266) Polymorphism in Congenital Heart Disease: A Meta-Analysis. [PDF]
Med Sci Monit, 2021 Background We performed the present study to better elucidate the correlation of reduced folate carrier-1 (RFC1) A80G (rs1051266) polymorphism with the risk of congenital heart disease (CHD).
Yi K +9 more
europepmc +2 more sources
Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. [PDF]
Bioorg Med Chem, 2020 Tumor-targeted 6-substituted pyrrolo[2,3-d]pyrimidine benzoyl compounds based on 2 were isosterically modified at the 4-carbon bridge by replacing the vicinal (C11) carbon by heteroatoms N (4), O (5) or S (6), or with an N-substituted formyl (7 ...
Golani LK +6 more
europepmc +2 more sources