Methotrexate recognition by the human reduced folate carrier SLC19A1.
Biophysical Journal, 2023 Folates are essential nutrients with important roles as cofactors in one-carbon transfer reactions, being heavily utilized in the synthesis of nucleic acids and the metabolism of amino acids during cell division1,2. Mammals lack de novo folate synthesis pathways and thus rely on folate uptake from the extracellular milieu3.
Justin G. Fedor +8 more
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Reduced Folate Carrier: an Entry Receptor for a Novel Feline Leukemia Virus Variant. [PDF]
J Virol, 2019 Feline leukemia virus (FeLV) is a member of the genus Gammaretrovirus, which causes malignant diseases in cats. The most prevalent FeLV among cats is FeLV subgroup A (FeLV-A), and specific binding of FeLV-A Env to its viral receptor, thiamine transporter
Miyake A +7 more
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Methotrexate recognition by the human reduced folate carrier SLC19A1. [PDF]
Nature, 2022 Wright NJ +8 more
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Post-transcriptional regulation of the human reduced folate carrier as a novel adaptive mechanism in response to folate excess or deficiency. [PDF]
Biosci Rep, 2014 The RFC (reduced folate carrier) is the principal mechanism by which folates and clinically used antifolates are delivered to mammalian cells. hRFC (human RFC) is subject to complex transcriptional controls and exists as homo-oligomer.
Hou Z, Orr S, Matherly LH.
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Polymorphisms and methylation of the reduced folate carrier in osteosarcoma. [PDF]
Clin Orthop Relat Res, 2008 High-dose methotrexate is a standard component in the treatment of osteogenic sarcoma. Impaired methotrexate uptake associated with decreased reduced folate carrier expression is a common mechanism of methotrexate resistance in osteogenic sarcoma samples.
Yang R +4 more
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Frontiers in Cell and Developmental Biology, 2022 The neural plate border (NPB) of vertebrate embryos segregates from the neural and epidermal regions, and it is comprised of an intermingled group of multipotent progenitor cells. Folate is the precursor of S-adenosylmethionine, the main methyl donor for
Nagif Alata Jimenez +1 more
doaj +2 more sources
A humanized mouse model for the reduced folate carrier. [PDF]
Mol Genet Metab, 2008 The ubiquitously expressed reduced folate carrier (RFC) or SLC19A1 is recognized to be an essential transport system for folates in mammalian cells and tissues. In addition to its generalized role as a folate transporter, RFC provides specialized tissue functions including absorption across intestinal/colonic epithelia, transport across the basolateral
Patterson D +3 more
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Frontiers in Bioengineering and Biotechnology, 2023 The carrier-free chemo-photothermal therapy has become a promising strategy to improve anti-cancer therapeutic efficacy owing to the combination of chemotherapy and photothermal therapy, with improved chemotherapy drug pharmacodynamics and ...
Shuang Kuang +5 more
doaj +2 more sources
Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier. [PDF]
Mol Pharm, 2017 Alam C +4 more
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The reduced folate carrier (RFC-1) 80A>G polymorphism and maternal risk of having a child with Down syndrome: a meta-analysis. [PDF]
Nutrients, 2013 A common polymorphism (c.80A>G) in the gene coding for the reduced folate carrier (SLC19A1, commonly known as RFC-1) has been associated with maternal risk of the birth of a child with Down Syndrome (DS), but results are controversial.
Coppedè F, Lorenzoni V, Migliore L.
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