Results 21 to 30 of about 171,869 (285)

Ischemia-Reperfusion Injury Reduces Kidney Folate Transporter Expression and Plasma Folate Levels

Frontiers in Immunology, 2021
Acute or chronic kidney disease can cause micronutrient deficiency. Patients with end-stage renal disease, kidney transplantation or on dialysis have reduced circulating levels of folate, an essential B vitamin.
Cheng Yang, Cheng Yang, Charith U. B. Wijerathne, Charith U. B. Wijerathne, Guo-wei Tu, Connie W. H. Woo, Yaw L. Siow, Yaw L. Siow, Yaw L. Siow, Susara Madduma Hewage, Susara Madduma Hewage, Kathy K. W. Au-Yeung, Kathy K. W. Au-Yeung, Tongyu Zhu, Tongyu Zhu, Karmin O, Karmin O, Karmin O   +17 more
doaj   +1 more source

Biochemical and molecular mechanisms of folate transport in rat pancreas; interference with ethanol ingestion. [PDF]

PLoS ONE, 2011
Folic acid is an essential nutrient that is required for one-carbon biosynthetic processes and for methylation of biomolecules. Deficiency of this micronutrient leads to disturbances in normal physiology of cell.
Nissar Ahmad Wani, Ritambhara Nada, Jyotdeep Kaur   +2 more
doaj   +1 more source

Selenofolate inhibits the proliferation of IGROV1 cancer cells independently from folate receptor alpha

Heliyon, 2021
Cancer is one of the main causes of human mortality worldwide and novel chemotherapeutics are required due to the limitations of conventional cancer therapies.
Ali Razaghi, Antje Maria Zickler, Julian Spallholz, Gilbert Kirsch, Mikael Björnstedt   +4 more
doaj   +1 more source

Reduced folate carrier 80A→G polymorphism, plasma folate, and risk of placental abruption [PDF]

Human Genetics, 2008
Folate deficiency and maternal smoking are strong risk factors for placental abruption. We assessed whether the reduced folate carrier [NM_194255.1: c.80A-->G (i.e., p.His27Arg)] (RFC-1) polymorphism was associated with placental abruption, and evaluated if maternal smoking modified the association between plasma folate and abruption. Data were derived
Cande V, Ananth, Morgan R, Peltier, Dirk F, Moore, Wendy L, Kinzler, Daniel, Leclerc, Rima R, Rozen   +5 more
openaire   +2 more sources

Interaction between dolutegravir and folate transporters and receptor in human and rodent placenta

EBioMedicine, 2022
Summary: Background: Due to the critical role of folates in neurodevelopment, it is important to understand potential interactions between anti-HIV drugs used during pregnancy, and folate delivery pathways in the placenta.
Julian C. Gilmore, Md. Tozammel Hoque, Wanying Dai, Haneesha Mohan, Caroline Dunk, Lena Serghides, Reina Bendayan   +6 more
doaj   +1 more source

Nuclear respiratory factor 1 (NRF‐1) upregulates the expression and function of reduced folate carrier (RFC) at the blood‐brain barrier

The FASEB Journal, 2020
Folates are important for neurodevelopment and cognitive function. Folate transport across biological membranes is mediated by three major pathways: folate receptor alpha (FRα), proton‐coupled folate transporter (PCFT), and reduced folate carrier (RFC ...
C. Alam, Md Tozammel Hoque, Vishal Sangha, R. Bendayan   +3 more
semanticscholar   +1 more source

Protective effects of pyrroloquinoline quinone in brain folate deficiency

Fluids and Barriers of the CNS, 2023
Background Folates (Vitamin B9) are critical for normal neurodevelopment and function, with transport mediated by three major pathways: folate receptor alpha (FRα), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).
Vishal Sangha, Sara Aboulhassane, Qing Rui Qu, Reina Bendayan   +3 more
doaj   +1 more source

Novel localization of folate transport systems in the murine central nervous system

Fluids and Barriers of the CNS, 2022
Background Folates are a family of B9 vitamins that serve as one-carbon donors critical to biosynthetic processes required for the development and function of the central nervous system (CNS) in mammals.
Vishal Sangha, Md. Tozammel Hoque, Jeffrey T. Henderson, Reina Bendayan   +3 more
doaj   +1 more source

Genetic polymorphisms of vitamin B12 and folate transporter proteins and depression in postpartum period: A case-control study

Journal of Affective Disorders Reports, 2021
Vitamin B12 and folate deficiency have been linked to the susceptibility of developing depression in the postpartum period. Transcobalamin-2 (TCN-2) and reduced folate carrier (RFC-1) are essential for the cellular uptake of vitamin B12 and folate ...
Pooja Dhiman, Raji Ramachandran Pillai, Anand Babu Wilson, Nancy Premkumar, Balaji Bharadwaj, P. Veena, Soundravally Rajendiran   +6 more
doaj   +1 more source

Reduced folate carrier polymorphism (80A→G) and neural tube defects [PDF]

European Journal of Human Genetics, 2003
Transport of folates in mammalian cells occurs by a carrier-mediated mechanism. The human folate carrier (RFC-1) gene has been isolated and characterized. Within this gene, a common polymorphism, 80A-->G, changing a histidine to an arginine in exon 2 (H27R), was recently identified.
Patrizia, De Marco, Maria Grazia, Calevo, Anna, Moroni, Elisa, Merello, Alessandro, Raso, Richard H, Finnell, Huiping, Zhu, Luciano, Andreussi, Armando, Cama, Valeria, Capra   +9 more
openaire   +2 more sources