Results 121 to 130 of about 28,838 (266)

Reductive Stress-Induced Biofilm Formation Mediates Mycobacterial Resistance to Macrophage Capture and Nitric Oxide Exposure

Applied Microbiology
Mycobacteria form cellulose-containing biofilms and exhibit drug resistance at infection sites. However, the function of mycobacterial biofilms in host defense remains unclear.
Shota Torigoe, Kentaro Yamamoto, Manabu Ato   +2 more
doaj   +1 more source

The Reductive Stress Reducto-miR: Emerging Insight into microRNA-671

, 2019
Excessive accumulation of reactive oxygen and nitrogen species (ROS/RNS) promotes cardiac pathophysiology. Although extreme oxidative burden is cytotoxic, ROS/RNS are continually generated within multiple domains of cardiac myocytes, and these species ...
Quiles, Justin Michael
core  

The Effect of Endoplasmic Reticulum and Reductive Stress on the Human Dermal Fibroblast Proteome [PDF]

, 2018
Dermal fibroblasts are responsible for the secretion of extracellular matrix (ECM) components that support the structural integrity of the skin. Alterations to the ECM have been implicated in many skin diseases including systemic sclerosis and fibrotic ...
CARNE, NAOMI,ANGHARAD
core  

NADH-reductive stress in Saccharomyces cerevisiae induces the expression of the minor isoform of glyceraldehyde-3-phosphate dehydrogenase (TDH1)

, 2004
A strain of Saccharomyces cerevisiae lacking the GPD2 gene, encoding one of the glycerol-3-phosphate dehydrogenases, grows slowly under anaerobic conditions, due to reductive stress caused by the accumulation of cytoplasmic NADH. We used 2D-PAGE to study
Gustafsson, Lena, Adler, L,, Ansell, R.,, Norbeck, J,, Valadi, Åsa,, Blomberg, Anders,, Norbeck, Joakim, Valadi, Åsa, Valadi, Hadi, Norbeck, Joakim,, Valadi, \uc5sa, Valadi, H,, Blomberg, A,, Gustafsson, L,, Gustafsson, Lena,, Valadi, A,, Ansell, R., Adler, Lennart,, Ansell, Ricky,, Adler, Lennart, Valadi, Hadi,, Blomberg, Anders   +21 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Aggregation of Albumins under Reductive Radical Stress

The reactions of radicals with human serum albumin (HSA) under reductive stress conditions were studied using pulse radiolysis and photochemical methods.
Karolina Radomska, Liwia Lebelt, Marian Wolszczak   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Engineering probiotic biohydrogen micro-factories to initiate reductive stress for boosting tumor vulnerability

Disruption of redox homeostasis profoundly affects cellular metabolism and activities. While oxidative stress is extensively studied in cancer therapies, research on reductive stress remains in its infancy.
Zheng, Huizhen, Zheng, Xinyi, Gao, Meng, Lu, Yuhao, Jiang, Jie, Xie, Maomao, Jauković, Aleksandra   +6 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source