Results 131 to 140 of about 27,691 (245)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ATP-Citrate Lyase in Heart Failure

JACC: Basic to Translational Science
David Weissman, MSc, Christoph Maack, MD
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Exploring reductive stress as a regulation approach for <i>Pseudomonas Aeruginosa</i> biofilm. [PDF]

iScience
Liu J, Li Y, Yan K, Han J, Wu Z, Li Y.
europepmc   +1 more source

Transgenic Expression of Nrf2 Induces a Pro-Reductive Stress and Adaptive Cardiac Remodeling in the Mouse. [PDF]

Genes (Basel), 2022
Jyothidasan A, Sunny S, Murugesan S, Quiles JM, Challa AK, Dalley B, Cinghu SK, Nanda V, Rajasekaran NS.   +8 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Reductive stress and the role of antioxidants in male infertility: a narrative review. [PDF]

Arch Gynecol Obstet
Moustakli E, Christopoulos P, Potiris A, Zikopoulos A, Matsas A, Arkoulis I, Mavrogianni D, Drakaki E, Zachariou A, Drakakis P, Stavros S.   +10 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Cognitive Impairment in Psychotic Disorders Is Associated with Brain Reductive Stress and Impaired Energy Metabolism as Measured by 31P Magnetic Resonance Spectroscopy. [PDF]

Schizophr Bull
Chouinard VA, Du F, Chen X, Tusuzian E, Ren B, Anderson J, Cuklanz K, Feizi W, Zhou S, Weerasekera A, Cohen BM, Öngür D, Lewandowski KE.   +12 more
europepmc   +1 more source

Endoplasmic reticulum oxidoreductin provides resilience against reductive stress and hypoxic conditions by mediating luminal redox dynamics. [PDF]

Plant Cell, 2022
Ugalde JM, Aller I, Kudrjasova L, Schmidt RR, Schlößer M, Homagk M, Fuchs P, Lichtenauer S, Schwarzländer M, Müller-Schüssele SJ, Meyer AJ.   +10 more
europepmc   +1 more source