Results 101 to 110 of about 2,924,310 (221)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Development of a Photoactivatable Phosphine Probe for Induction of Intracellular Reductive Stress with Single-Cell Precision

, 2016
Photoactivatable phosphines that induce intracellular reductive stress are reported. The design of these probes takes advantage of the conjugate addn. of trialkylphosphines to carbocyanine dyes, which can be reverted photochem.
Rivera-Fuentes, Pablo, Tirla, Alina, Tirla A, Alina Tirla, Pablo Rivera‐Fuentes, Rivera-Fuentes P   +5 more
core   +1 more source

Progressive salinity drives flavonoid branch reprogramming in Anoectochilus roxburghii

BMC Plant Biology
Flavonoids play critical roles in plant adaptation to abiotic stress; however, how salt stress modulates metabolic flux distribution within flavonoid branches remains poorly understood, particularly in non-model medicinal plants.
Huiming Huang, Wenqing Bao, Jiangbo Lin, Jiamin Hong, Xiaowei Yu, Yimin Dai   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Reductive Stress-Induced Biofilm Formation Mediates Mycobacterial Resistance to Macrophage Capture and Nitric Oxide Exposure

Applied Microbiology
Mycobacteria form cellulose-containing biofilms and exhibit drug resistance at infection sites. However, the function of mycobacterial biofilms in host defense remains unclear.
Shota Torigoe, Kentaro Yamamoto, Manabu Ato   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Representation theory of disconnected reductive groups

, 2020
International audienceWe study three fundamental topics in the representation theory of disconnected algebraic groups whose identity component is reductive: (i) the classification of irreducible representations; (ii) the existence and properties of Weyl ...
Hardesty, William, Achar, Pramod, N., Riche, Simon   +2 more
core   +1 more source

Identification of transcriptome signature for myocardial reductive stress

, 2017
The nuclear factor erythroid 2 like 2 (Nfe2l2/Nrf2) is a master regulator of antioxidant gene transcription. We recently identified that constitutive activation of Nrf2 (CaNrf2) caused reductive stress (RS) in the myocardium.
David Crossman, Gobinath Shanmugam, Madhusudhanan Narasimhan, Namakkal S. Rajasekaran, Justin M. Quiles, Timothy Mosbruger   +5 more
core   +1 more source