Results 101 to 110 of about 28,051 (225)

OX40/OX40L modulation: A target for regulating T cells in cutaneous inflammatory disorders

Journal of the European Academy of Dermatology and Venereology, EarlyView.
OX40 and OX40L are a co‐stimulatory immune checkpoint pair. Modulation of this pair impacts multiple immune phenotypes and is an attractive target for immunotherapy in dermatological disorders. Trials are underway with the majority in atopic dermatitis and currently in phase 3 trials.
Aditya K. Gupta, Julia Steriopoulos, Vasiliki Economopoulos, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study - A Randomized Clinical Trial [PDF]

, 2016
Background: Pimobendan is effective in treatment of dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD). Its effect on dogs before the onset of CHF is unknown.
Abbott, J A, Barrett, K A, Bomassi, E, Bonagura, J D, Boswood, A, Church, W M, Deinert, M, Del Palacio, M J F, Estrada, A H, Fox, P R, Fujii, Y, Gordon, S G, Haggstrom, J, Jaudon, J P, Keene, B W, Kresken, J G, Ljungvall, I, Luethy, M W, MacDonald, K A, Menaut, P, Moise, N S, O'Sullivan, M L, Oyama, M A, Patteson, M, Rosenthal, S L, Rush, J, Sanderson, K, Santilli, R A, Saunders, A B, Smith, S, Spier, A, Stepien, R L, Szatmari, V, Tidholm, A, Uechi, M, Watson, P, Wess, G, Woolley, R   +37 more
core   +3 more sources

Systematic literature review of treatments used for refractory or unexplained chronic cough in adults

Annals of Thoracic Medicine
BACKGROUND: Refractory or unexplained chronic cough (RCC or UCC) is difficult to manage and is usually treated by the off-label use of drugs approved for other indications.
Vishal Bali, Peter Kardos, Clive Page, Paola Rogliani, Luigino Calzetta, Ada Adriano, Aidan Byrne, Adekemi Adeyemi, Andrew Frederickson, Jonathan Schelfhout   +9 more
doaj   +1 more source

A pragmatic patient-reported outcome strategy for rare disease clinical trials: application of the EORTC item library to myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia. [PDF]

, 2019
BackgroundNovel, pragmatic, patient-centered strategies are needed to ensure fit-for-purpose patient-reported outcomes (PRO) instruments in clinical trial research for rare diseases such as myelodysplastic syndromes (MDS), acute myeloid leukemia (AML ...
Bejar, Rafael, Bell, Jill A, Cano, Stefan, Faller, Douglas V, Fram, Robert J, Galaznik, Aaron, Marquis, Patrick, Pompilus, Farrah, Scipione, Fatima, Strzok, Sara   +9 more
core  

Allergic bronchopulmonary aspergillosis: diagnostic and treatment challenges [PDF]

, 2016
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder, occurring mostly in asthmatic and cystic fibrosis patients, caused by an abnormal T-helper 2 lymphocyte response of the host to Aspergillus fumigatus antigens.
CINICOLA, BIANCA LAURA, DUSE, MARZIA, Laitano, Rossella, LEONARDI, LUCIA   +3 more
core   +1 more source

Pre‐anaesthetic risk assessment and management of dogs with myxomatous mitral valve disease: a spectrum of care narrative review

Journal of Small Animal Practice, EarlyView.
Myxomatous mitral valve disease, an acquired valvular degeneration, is the most common cardiac disorder in dogs, affecting approximately 10% of dogs in primary care veterinary practice. Dogs with myxomatous mitral valve disease frequently require anaesthesia for routine procedures.
I. Levinzon, L. Köster, E. Vettorato, A. H. Estrada   +3 more
wiley   +1 more source

Profile of cough triggers and their relationship with capsaicin cough sensitivity in chronic cough

Therapeutic Advances in Respiratory Disease
Background: Cough hypersensitivity is an important part of the neurophysiology of cough, which presents with increased cough response to a lower level of stimuli or triggers.
Tingting Xu, Zhiyin Chen, Chen Zhan, Wenzhi Zhan, Fang Yi, Kefang Lai   +5 more
doaj   +1 more source

Effect of weight loss on urinary incontinence in women. [PDF]

, 2011
BackgroundThe purpose of this research was review the epidemiology of the association of obesity and urinary incontinence, and to summarize the published data on the effect of weight loss on urinary incontinence.MethodsA literature review of the ...
Subak, Leslee L, Whitcomb, Emily L
core   +2 more sources

Studies of platelet antibodies at MacKay Memorial Hospital in Taiwan: Methods, case reviews and a possible case of post‐transfusion purpura

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Platelet antibody screening and identification are crucial and challenging. MacKay Memorial Hospital has been dedicated to this for nearly four decades. We reviewed our experience with platelet antibody detection methods and prevalence, and presented a possible case of post‐transfusion purpura caused by anti‐CD36 ...
Chiang Chen‐Yu, Chang Hsiao‐Lin, Chan Yung‐Shu, Cheng Wern‐Cherng, Lin Marie   +4 more
wiley   +1 more source

Managing patients with chronic cough: challenges and solutions

Therapeutics and Clinical Risk Management, 2018
Jeanne-Marie Perotin,1,2 Claire Launois,1 Maxime Dewolf,1 Antoine Dumazet,1 Sandra Dury,1 François Lebargy,1 Valérian Dormoy,2 Gaëtan Deslee1,2 1Department of Respiratory Diseases, University Hospital of Reims, Reims, France; 2INSERM ...
Perotin JM, Launois C, Dewolf M, Dumazet A, Dury S, Lebargy F, Dormoy V, Deslee G   +7 more
doaj