Results 21 to 30 of about 26,442 (182)

A randomized, double-blinded, placebo-controlled clinical trial of duloxetine hydrochloride enteric-coated tablets in the treatment of refractory chronic cough

BMC Pulmonary Medicine, 2023
Introduction Refractory cough, a chronic cough with an unclear diagnosis or poor treatment response. The symptoms are often stubborn and persistent, causing serious complications and lowering the patient's quality of life. Cough hypersensitivity syndrome
Shengyuan Wang, Shaohui Li, Heng Wu, Tongyangzi Zhang, Yixiao Chen, Yiqing Zhu, Siwan Wen, Cuiqin Shi, Li Yu, Xianghuai Xu   +9 more
doaj   +1 more source

Non-pharmacological Management of Non-productive Chronic Cough in Adults: A Systematic Review

Frontiers in Rehabilitation Sciences, 2022
BackgroundChronic cough is a common reason for medical referral and its prevalence is on the rise. With only one pharmaceutical therapy currently under review for the treatment of refractory chronic cough, exploring non-pharmacological chronic cough ...
Ana Maria Ilicic, Ana Oliveira, Ana Oliveira, Ana Oliveira, Ana Oliveira, Razanne Habash, Yejin Kang, Michelle Kho, Michelle Kho, Michelle Kho, Roger Goldstein, Roger Goldstein, Dina Brooks, Dina Brooks, Dina Brooks   +14 more
doaj   +1 more source

From bench to bedside: The role of cough hypersensitivity in chronic cough

Clinical and Translational Medicine, 2023
Background Chronic cough is a burdensome condition characterized by persistent cough lasting longer than 8 weeks. Chronic cough can significantly affect quality of life, physical function and productivity, with many people troubled with a cough that ...
Matthew G. Drake, Lorcan P. McGarvey, Alyn H. Morice   +2 more
doaj   +1 more source

“Chronic refractory cough with dyspnea” as presenting feature of metastatic renal cell carcinoma: “Beaded Interlobular Septum” on HRTC Thorax Needs Cautious Workup to Rule out Underlying Malignant Pathology

Journal of Applied Sciences and Clinical Practice, 2022
Cough is the most common respiratory symptoms with infective and noninfective etiological factors involving upper and lower airways. Chronic refractory cough (CRC) has limited etiology and associated symptoms play a crucial role in differentiating it ...
Shital Patil, Atul Deshmukh, Rupesh Gundawar   +2 more
doaj   +1 more source

Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial

BMC Pulmonary Medicine, 2023
Objective The purpose of this study was to collect pilot efficacy data on a novel treatment for refractory chronic cough (RCC), which we call cough desensitization treatment (CDT).
Laurie J. Slovarp, Jane E. Reynolds, Sophia Tolbert, Sarah Campbell, Shannon Welby, Paige Morkrid   +5 more
doaj   +1 more source

A double-blind randomised placebo-controlled trial investigating the effects of lesogaberan on the objective cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough

ERJ Open Research, 2022
Objective Baclofen is a centrally acting γ-aminobutyric acid type B (GABAB) receptor agonist which reduces gastro-oesophageal reflux and suppresses the cough reflex; however, central nervous system side-effects limit its use.
Huda Badri, Carmen Gibbard, Dimitra Denton, Imran Satia, Bashar Al-Sheklly, Rachel J. Dockry, Kimberley Holt, Kevin McGuiness, Sam Treadway, Peter Whorwell, Lesley Houghton, Augustine Lee, K. Jane Escott, Theresa Lee, Greame Wilkinson, Alison Holt, Brendan J. Canning, Jacky A. Smith   +17 more
doaj   +1 more source

A toddler with a cough and wheeze refractory to treatment [PDF]

Thorax, 2017
A 20-month-old girl weighing 12 kg presented with 2 weeks of worsening dry cough and wheeze. Aside from respiratory symptoms she was otherwise well, without fever or weight loss. There was no history of foreign body inhalation or choking. She had no significant personal or family medical history, and her immunisations were up to date.
Shivanthan, Shanthikumar, Tommy, Lwin, Chung W, Chow, Joe, Crameri, Jo, Harrison   +4 more
openaire   +2 more sources

Somatically evoked cough responses help to identify patients with difficult-to-treat chronic cough: a six-month observational cohort studyResearch in context

EClinicalMedicine, 2023
Summary: Background: Recently we identified in patients with chronic cough a sensory dysregulation via which the urge-to-cough (UTC) or coughing are evoked mechanically from “somatic points for cough” (SPCs) in the neck and upper trunk.
Federico Lavorini, Guja Bernacchi, Carlo Fumagalli, Marianna Noale, Stefania Maggi, Donatella Mutolo, Eliana Cinelli, Giovanni A. Fontana   +7 more
doaj   +1 more source

Impact of refractory and unexplained chronic cough on disease burden: a qualitative study

BMC Pulmonary Medicine, 2022
Background Chronic cough lasting for > 8 weeks is a common medical condition that burdens patients. This study aimed to qualitatively describe knowledge, awareness, experiences, and subtypes of burdens (physical, social, psychological) among Japanese ...
Naoya Ueda, Anzu Yakushiji, Jonathan Schelfhout, Shigeru Tokita, Takekazu Kubo   +4 more
doaj   +1 more source

Efficacy of Gefapixant, a P2X3 Antagonist, for Refractory Atopic Cough

International Medical Case Reports Journal, 2023
Yoshihisa Ishiura, Shosaku Nomura, Yuka Ishii, Kai Imai, Yusuke Sawai, Takeshi Tamaki, Toshiki Shimizu, Naoyuki Miyashita, Tomoki Ito First Department of Internal Medicine, Kansai Medical University, Osaka, JapanCorrespondence: Yoshihisa Ishiura, First ...
Ishiura Y, Nomura S, Ishii Y, Imai K, Sawai Y, Tamaki T, Shimizu T, Miyashita N, Ito T   +8 more
doaj