Results 31 to 40 of about 5,141,166 (402)

Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancers [PDF]

, 2011
Background: Gene regulation through cis-regulatory elements plays a crucial role in development and disease. A major aim of the post-genomic era is to be able to read the function of cis-regulatory elements through scrutiny of their DNA sequence ...
Bronner, Marianne E., Elgar, Greg, Parker, Hugo J., Piccinelli, Paul, Sauka-Spengler, Tatjana   +4 more
core   +5 more sources

Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

eLife, 2016
In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells is poorly understood. In mammals, MBNL proteins negatively regulate an exon program specific of embryonic stem cells; however, little is known about the in
Jordi Solana, Manuel Irimia, Salah Ayoub, Marta Rodriguez Orejuela, Vera Zywitza, Marvin Jens, Javier Tapial, Debashish Ray, Quaid Morris, Timothy R Hughes, Benjamin J Blencowe, Nikolaus Rajewsky   +11 more
doaj   +1 more source

Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury

Frontiers in Cell and Developmental Biology, 2020
Necroptosis is a form of regulated necrosis that requires the activation of receptor-interacting kinase 3 (RIPK3 or RIP3) and its phosphorylation of the substrate MLKL (mixed lineage kinase domain-like protein).
Kaijiang Xia, Fang Zhu, Fang Zhu, Fang Zhu, Fang Zhu, Chengkui Yang, Chengkui Yang, Chengkui Yang, Shuwei Wu, Yu Lin, Haikuo Ma, Xiaoliang Yu, Xiaoliang Yu, Xiaoliang Yu, Cong Zhao, Cong Zhao, Cong Zhao, Yuting Ji, Yuting Ji, Yuting Ji, Yuting Ji, Wenxiang Ge, Wenxiang Ge, Wenxiang Ge, Jingrui Wang, Jingrui Wang, Jingrui Wang, Yayun Du, Yayun Du, Yayun Du, Yayun Du, Wei Zhang, Wei Zhang, Wei Zhang, Tao Yang, Tao Yang, Tao Yang, Tao Yang, Xiaohu Zhang, Sudan He, Sudan He, Sudan He, Sudan He   +42 more
doaj   +1 more source

MicroRNAs as regulatory elements in psoriasis

Open Medicine, 2016
Abstract Psoriasis is a chronic, autoimmune, and complex genetic disorder that affects 23% of the European population. The symptoms of Psoriatic skin are inflammation, raised and scaly lesions. microRNA, which is short, nonprotein-coding, regulatory RNAs, plays critical roles in psoriasis.
Quanzhong Liu, Yuan Liu
openaire   +4 more sources

Systematic discovery of structural elements governing stability of mammalian messenger RNAs. [PDF]

, 2012
Decoding post-transcriptional regulatory programs in RNA is a critical step towards the larger goal of developing predictive dynamical models of cellular behaviour.
Cristea, Ileana M, Fish, Lisa, Goodarzi, Hani, Greco, Todd M, Najafabadi, Hamed S, Oikonomou, Panos, Salavati, Reza, Tavazoie, Saeed   +7 more
core   +2 more sources

An atlas of gene regulatory elements in adult mouse cerebrum

Nature, 2020
The mammalian cerebrum performs high-level sensory perception, motor control and cognitive functions through highly specialized cortical and subcortical structures1.
Y. Li, Sebastian Preissl, Xiaomeng Hou, Ziyang Zhang, Kai Zhang, Yunjiang Qiu, Olivier B. Poirion, Bin Li, Joshua Chiou, Hanqing Liu, A. Pinto-Duarte, Naoki Kubo, Xiaoyu Yang, Rongxin Fang, Xinxin Wang, Jee Yun Han, J. Lucero, Yiming Yan, Michael Miller, Samantha Kuan, David U. Gorkin, K. Gaulton, Yin Shen, M. Nunn, E. Mukamel, M. Behrens, J. Ecker, B. Ren   +27 more
semanticscholar   +1 more source

Expand+Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors [PDF]

, 2010
Despite the critical role of pre-mRNA splicing in generating proteomic diversity and regulating gene expression, the sequence composition and function of intronic splicing regulatory elements (ISREs) have not been well elucidated.
Berglund, J. Andrew, Culler, Stephanie J., Hoff, Kevin G., Smolke, Christina D., Voelker, Rodger B.   +4 more
core   +4 more sources

Multigenome DNA sequence conservation identifies Hox cis-regulatory elements [PDF]

, 2008
To learn how well ungapped sequence comparisons of multiple species can predict cis-regulatory elements in Caenorhabditis elegans, we made such predictions across the large, complex ceh-13/lin-39 locus and tested them transgenically. We also examined how
De Buysscher, Tristan, DeModena, John A., Kuntz, Steven G., Schwarz, Erich M., Shizuya, Hiroaki, Sternberg, Paul W., Trout, Diane, Wold, Barbara J.   +7 more
core   +3 more sources

Expression Profiling of Salt-Responsive Genes and Transcription Factors in Leaf Transcriptome of Arabidopsis thaliana

Diversity, 2023
This investigation discerns the expression profiles of genes within the leaf transcriptome of Arabidopsis thaliana subjected to salt stress (200 mM NaCl).
Nahaa M. Alotaibi, Aala A. Abulfaraj
doaj   +1 more source

A unified architecture of transcriptional regulatory elements [PDF]

Trends in Genetics, 2015
AbstractGene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications.
Andersson, Robin, Sandelin, Albin, Danko, Charles G   +2 more
openaire   +5 more sources