Results 31 to 40 of about 5,375,401 (399)
eLife, 2016 In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells is poorly understood. In mammals, MBNL proteins negatively regulate an exon program specific of embryonic stem cells; however, little is known about the in
Jordi Solana +11 more
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Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancers [PDF]
, 2011 Background: Gene regulation through cis-regulatory elements plays a crucial role in development and disease. A major aim of the post-genomic era is to be able to read the function of cis-regulatory elements through scrutiny of their DNA sequence ...
Bronner, Marianne E. +4 more
core +5 more sources
Frontiers in Bioengineering and Biotechnology, 2022 Bacteria belonging to Streptomyces have the ability to produce a wide range of secondary metabolites through a shift from primary to secondary metabolism regulated by complex networks activated after vegetative growth terminates.
Soonkyu Hwang +22 more
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Expand+Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors [PDF]
, 2010 Despite the critical role of pre-mRNA splicing in generating proteomic diversity and regulating gene expression, the sequence composition and function of intronic splicing regulatory elements (ISREs) have not been well elucidated.
Berglund, J. Andrew +4 more
core +4 more sources
Frontiers in Cell and Developmental Biology, 2020 Necroptosis is a form of regulated necrosis that requires the activation of receptor-interacting kinase 3 (RIPK3 or RIP3) and its phosphorylation of the substrate MLKL (mixed lineage kinase domain-like protein).
Kaijiang Xia +42 more
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Mechanisms of robustness in gene regulatory networks involved in neural development
Frontiers in Molecular Neuroscience, 2023 The functions of living organisms are affected by different kinds of perturbation, both internal and external, which in many cases have functional effects and phenotypic impact.
Camila D. Arcuschin +4 more
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Multigenome DNA sequence conservation identifies Hox cis-regulatory elements [PDF]
, 2008 To learn how well ungapped sequence comparisons of multiple species can predict cis-regulatory elements in Caenorhabditis elegans, we made such predictions across the large, complex ceh-13/lin-39 locus and tested them transgenically. We also examined how
De Buysscher, Tristan +7 more
core +3 more sources
Uncovering Drug-Responsive Regulatory Elements
Pharmacogenomics, 2015 Nucleotide changes in gene regulatory elements can have a major effect on interindividual differences in drug response. For example, by reviewing all published pharmacogenomic genome-wide association studies, we show here that 96.4% of the associated single nucleotide polymorphisms reside in noncoding regions. We discuss how sequencing technologies are
Luizon, Marcelo R, Ahituv, Nadav
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Arabidopsis thalianaregulatory element analyzer [PDF]
Bioinformatics, 2008 AbstractSummary: In the Arabidopsis thaliana regulatory element analyzer (AtREA) server, we have integrated sequence data, genome-wide expression data and functional annotation data in three application modules which will be useful to identify major regulatory targets of a user-provided cis-regulatory element (CRE), study different features of CRE ...
Ananyo, Choudhury, Ansuman, Lahiri
openaire +2 more sources
Cell Reports, 2020 Summary: circSLC45A4 is the main RNA splice isoform produced from its genetic locus and one of the highest expressed circRNAs in the developing human frontal cortex.
Christin Suenkel +4 more
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