Results 201 to 210 of about 1,033,187 (394)

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses [PDF]

, 2001
Roger P.M. Sutmuller, Leonie M. van Duivenvoorde, Andrea van Elsas, Ton N. Schumacher, Manon E. Wildenberg, James P. Allison, René E. M. Toes, Rienk Offringa, Cornelis J.M. Melief   +8 more
openalex   +1 more source

Carbon Dot‐Linked Hydrogel for TAMs Transform: Spatiotemporal Manipulation to Reshape Tumor Microenvironment

Advanced Materials, EarlyView.
The CDs crosslinked egg white hydrogel loaded with lipopolysaccharide (LPS) and CA170 (TTF‐L‐C) can realize spatiotemporal tumor‐associated macrophages (TAMs) transformation from multi‐level dimensions, including spatial recruitment, cell phenotype reprogramming, and immune checkpoint molecule blockade.
Lingyun Li, Jun Wu, Xue Wu, Zhenjian Li, Xianming Zhang, Zekun Yan, Yingqi Liang, Caishi Huang, Songnan Qu   +8 more
wiley   +1 more source

Specific features of lymphoid infiltration in liver biopsy in patients with chronic viral hepatitis B and C

Терапевтический архив, 2011
Aim. To study characteristics of leukocytic infiltration of the liver in patients with chronic viral hepatitis B and C (CVHB and CVHC) with consideration of hepatitis activity and fibrosis severity. Material and methods.
Karina Turakbaevna Umbetova, Anna Svyatoslavovna Lazareva, Mikhail Valentinovich Kiselevskiy, Yuriy Georgievich Parkhomenko, Elena Vasil'evna Volchkova, Sergey Grigor'evich Pak, K T Umbetova, A S Lazareva, M V Kiselevsky, Yu G Parkhomenko, E V Volchkova, S G Pak   +11 more
doaj  

Chemokine Receptor Expression and Function in CD4+ T Lymphocytes with Regulatory Activity [PDF]

, 2001
Silvia Sebastiani, Paola Allavena, Cristina Albanesi, Francesca Nasorri, Giuseppe Bianchi, Claudia Traidl‐Hoffmann, Silvano Sozzani, Giampiero Girolomoni, Andrea Cavani   +8 more
openalex   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Editorial: Regulatory Mechanisms of Early Intracellular Signaling in T Lymphocytes

Frontiers in Cell and Developmental Biology, 2021
Enrique Aguado, Enrique Aguado, Ewoud B. Compeer, Arkadiusz Miazek   +3 more
doaj   +1 more source

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source

Hepatitis C Virus Core Protein Inhibits Human T Lymphocyte Responses by a Complement-Dependent Regulatory Pathway [PDF]

, 2001
Zhi Q. Yao, Duong Tony Nguyen, Apostolos I. Hiotellis, Young S. Hahn   +3 more
openalex   +1 more source

Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy

Advanced Science, EarlyView.
This study reveals that KMT5C activates DNA damage repair to inhibit STING‐IRF3 pathway, downstream type I IFN signaling and CCL5 secretion, leading to the downregulation of CD8+ T cell infiltration and function in NSCLC, ultimately facilitating tumor progression.
Yunfeng Yuan, Qianyu Li, Guoquan Yan, Yifei Qian, Wenyun Guo, Songling Li, Fan Wang, Wanjing Shang, Zijun Zhu, Di Ge, Yanan Wang, Yanfeng Liu   +11 more
wiley   +1 more source