Results 71 to 80 of about 106,778 (281)
Frontiers in Behavioral Neuroscience, 2013 Stimuli previously associated with drugs of abuse can become triggers that elicit craving and lead to drug-seeking behavior. The basolateral amygdala (BLA) is a key neural structure involved in cue-induced reinstatement of cocaine seeking.
Michael T. Stefanik, Peter W. Kalivas
doaj +1 more source
Advanced Science, EarlyView.Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao +3 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Land Use Dynamics of Drove Roads: The Case of Tratturo Castel di Sangro-Lucera (Molise, Italy)
Land, 2018 Organized transhumant pastoralism has contributed to shaping the cultural landscape of many countries. It has affected areas designated for grazing, temporary and permanent shelters, and towns.
Michele Minotti +3 more
doaj +1 more source
Policy and Practice Brief: Expedited Reinstatement of Social Security or SSI Disability Benefits [PDF]
, 2006 This brief covers the expedited reinstatement (EXR) provision, introduced into the Social Security Disability Insurance (SSDI) and Supplemental Security Income (SSI) programs in January 2001.
Sheldon, James R.
core +1 more source
Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes
Advanced Science, EarlyView.Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang +14 more
wiley +1 more source
The promises and pitfalls of retrieval-extinction procedures in preventing relapse to drug seeking
Frontiers in Psychiatry, 2013 Relapse to drug seeking after treatment or a period of abstinence remains a fundamental challenge for drug users. The retrieval – extinction procedure offers promise in augmenting the efficacy of exposure based treatment for drug use and for protecting ...
Gavan P McNally +1 more
doaj +1 more source
Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface
Advanced Science, EarlyView.Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley +1 more source
Frontiers in Psychology, 2015 The present experiment investigated potential reinstaters of suboptimal economic decision making in rats. Rats were first trained on a version of the rat Gambling Task under conditions designed to promote choice of a suboptimal option that occasionally ...
Nina P. Connolly +3 more
doaj +1 more source
Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence [PDF]
, 2017 We recently developed a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and dorsomedial striatum (DMS) in this incubation.
Bossert, Jennifer M. +6 more
core +2 more sources