Results 71 to 80 of about 113,150 (329)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

An Adaptive Reconfiguration Mechanism for Periodic Software Rejuvenation based on Transient Reliability Analysis

open access: yesMATEC Web of Conferences, 2018
While software rejuvenation is used to prevent severe software failures, existing researches generally choose the constant-value periodic policy through steady-state reliability optimization.
He Pan, Liu Gang, Yuan Yue
doaj   +1 more source

Immune system rejuvenation—approaches and real achievements

open access: yesExploration of Immunology, 2023
Interest in the mechanisms of aging of the immune system has not faded over the past 100 years, and it is caused by the immune-mediated development of age-related pathology, including autoimmune organ damage, reduced vaccination efficiency ...
Iryna Pishel
doaj   +1 more source

Semi-independent resampling for particle filtering

open access: yes, 2017
Among Sequential Monte Carlo (SMC) methods,Sampling Importance Resampling (SIR) algorithms are based on Importance Sampling (IS) and on some resampling-based)rejuvenation algorithm which aims at fighting against weight degeneracy.
Desbouvries, François   +3 more
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

The 5-Step Filler Hand Rejuvenation: Filling with Hyaluronic Acid

open access: yesPlastic and Reconstructive Surgery, Global Open, 2019
Many patients are pursuing simultaneous facial and hand rejuvenation with the latter receiving increased interest in recent years. Various materials have been purported to rejuvenate the hands including fat, calcium hydroxyapatite, and hyaluronic fillers.
Nima Khosravani, BS, MS   +3 more
doaj   +1 more source

Heartbreak hotel: a convergence in cardiac regeneration [PDF]

open access: yes, 2016
In February 2016, the Company of Biologists hosted an intimate gathering of leading international researchers at the forefront of experimental cardiovascular regeneration, with its emphasis on ‘Transdifferentiation and Tissue Plasticity in Cardiovascular
Schneider, MD
core   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

A Model for Availability and Security Risk Evaluation for Systems With VMM Rejuvenation Enabled by VM Migration Scheduling

open access: yesIEEE Access, 2019
Most companies and organizations rely nowadays on virtualized environments to host and run their applications. Some of these applications have stringent availability and security requirements.
Matheus Torquato   +2 more
doaj   +1 more source

REJUVENATING HUMAN CAPITAL IN SYARIAH LEGAL INSTITUTIONS THROUGH FIQH FORENSICS FUNDAMENTAL MODULE: A PRELIMINARY REVIEW

open access: yesMalaysian Journal of Syariah and Law, 2020
The development of science and technology today has contributed to the advancement of evidence law in the Civil Courts as well as Syariah Courts. The said application of science and technology refers to the scientific evidence produced from the results ...
Muhammad Hazim Ahmad   +5 more
doaj   +1 more source

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