Results 71 to 80 of about 103,312 (279)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A microscopic mechanism for rejuvenation and memory effects in spin glasses

, 2001
Aging in spin glasses (and in some other systems) reveals astonishing effects of `rejuvenation and memory' upon temperature changes. In this paper, we propose microscopic mechanisms (at the scale of spin-spin interactions) which can be at the origin of ...
Miyashita, S., Vincent, E.
core   +3 more sources

Proactive cloud management for highly heterogeneous multi-cloud infrastructures [PDF]

, 2016
Various literature studies demonstrated that the cloud computing paradigm can help to improve availability and performance of applications subject to the problem of software anomalies.
Avresky, Dimiter R., DI SANZO, Pierangelo, Pellegrini, Alessandro   +2 more
core   +1 more source

LASMIK laser biorevitalization: mechanisms and therapeutic experience

Dermatology Reports, 2020
LASMIK laser biorevitalization is a well-known technology developed in Russia that is based on laser phoresis as a method to enhance percutaneous penetration of substances. The article describes the mechanisms that act here and factors that determine the
Sergey Vladimirovich Moskvin, Aleksandr Agubechirovich Khadartsev   +1 more
doaj   +1 more source

Rejuvenation of Senescent Bone Marrow Mesenchymal Stromal Cells by Pulsed Triboelectric Stimulation

Advanced Science, 2021
Stem cell senescence contributes to stem cell exhaustion and drives various aging‐associated disorders. However, strategies to rejuvenate senescent stem cells are limited.
Gaocai Li, Qianqian Zhu, Bingjin Wang, Rongjin Luo, Xiaohui Xiao, Yi Zhang, Liang Ma, Xiaobo Feng, Jingang Huang, Xuhui Sun, Zhen Wen, Yue Pan, Cao Yang   +12 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Temperature shifts in the Sinai model: static and dynamical effects

, 2002
We study analytically and numerically the role of temperature shifts in the simplest model where the energy landscape is explicitely hierarchical, namely the Sinai model.
Aspelmeier T, Berthier L, Berthier L, Billoire A, Bouchaud J-P, Bouchaud J-P, Bouchaud J-P, Bouchaud J-P, Bouchaud J-P, Broderix K, Cavagna A, da Silveira R, Feller W, F lix Ritort, Goldstein M, Hammann J, Jean-Philippe Bouchaud, Jonsson P E, Kawasaki M, Komori T, Komori T, Komori T, Kondor I, Kurchan J, Le Doussal P, Lubensky D, Luding S, Marta Sales, Monthus C, Mézard M, Mézard M, Ney-Nifle M, Oshanin G, Parisi G, Parker A, Refregier Ph, Rizzo T, Rizzo T, Sales M, Sasaki M, Sasaki M, Sasaki M, Vincent E, Vincent E   +43 more
core   +1 more source

Heartbreak hotel: a convergence in cardiac regeneration [PDF]

, 2016
In February 2016, the Company of Biologists hosted an intimate gathering of leading international researchers at the forefront of experimental cardiovascular regeneration, with its emphasis on ‘Transdifferentiation and Tissue Plasticity in Cardiovascular
Schneider, MD
core   +1 more source

PPARgamma Deficiency Counteracts Thymic Senescence

Frontiers in Immunology, 2017
Thymic senescence contributes to increased incidence of infection, cancer and autoimmunity at senior ages. This process manifests as adipose involution. As with other adipose tissues, thymic adipose involution is also controlled by PPARgamma.
David Ernszt, David Ernszt, Krisztina Banfai, Krisztina Banfai, Zoltan Kellermayer, Attila Pap, Janet M. Lord, Judit E. Pongracz, Judit E. Pongracz, Krisztian Kvell, Krisztian Kvell   +10 more
doaj   +1 more source

Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies

Frontiers in Cell and Developmental Biology, 2020
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and differentiation. There is increasing evidence of the therapeutic value of MSCs in various clinical situations, however, these cells gradually lose their regenerative ...
Jing Liu, Jing Liu, Yue Ding, Zhongmin Liu, Zhongmin Liu, Xiaoting Liang, Xiaoting Liang   +6 more
doaj   +1 more source