Results 111 to 120 of about 1,855,106 (245)

RelA-Induced Interferon Response Negatively Regulates Proliferation

PLOS ONE, 2015
Both oncogenic and tumor-suppressor activities are attributed to the Nuclear Factor kappa B (NF-kB) pathway. Moreover, NF-kB may positively or negatively regulate proliferation. The molecular determinants of these opposing roles of NF-kB are unclear. Using primary human mammary epithelial cells (HMEC) as a model, we show that increased RelA levels and ...
Kochupurakkal, Bose, Wang, Zhigang C., Hua, Tony, Culhane, Aedin, Rodig, Scott, Rajkovic-Molek, Koraljka, Lazaro, Jean-Bernard, Richardson, Andrea, Biswas, Debajit, Iglehart, James   +9 more
openaire   +5 more sources

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: implications in colon cancer

Journal of Experimental & Clinical Cancer Research, 2019
Background RelA/p65 a crucial member of NF-κB signaling pathway plays diverse role in mediating oncogenesis. Limited knowledge prevails on the mechanistic insights of RelA gene regulation.
Veenita Khare, Shaheda Tabassum, Uttara Chatterjee, Sandip Chatterjee, Mrinal K. Ghosh   +4 more
doaj   +1 more source

Impact of obesity and an obesogenic environment on cardiotoxin‐induced damage and recovery of human myotubes

Experimental Physiology, EarlyView.
Abstract Obesity (BMI ≥ 30 kg/m2) reduces skeletal muscle quality and impairs the myogenic response to muscle damage. The present study investigated if differences exist in myotubes from individuals with (OB) or without (LN) obesity incubated in control (bovine serum albumin [BSA]) or obesogenic (Ob) medium, at baseline or in response to cardiotoxin ...
Brian P. Sullivan, Lundon C. Burton, Allison Ellis, Christopher K. Kargl, Deborah Shera, Shihuan Kuang, James F. Markworth, Timothy P. Gavin   +7 more
wiley   +1 more source

Reprogramming SREBP1‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention

International Journal of Cancer, Volume 158, Issue 7, Page 1927-1940, 1 April 2026.
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley, Seyyedmohsen Hosseinibarkooie, Zahra Assadi, Shao Huan Samuel Weng, Raymond Moellering, Oukseub Lee, Ruohui Chen, Wonhwa Cho, Sriram Chandrasekaran, Susan E. Clare, Seema A. Khan   +14 more
wiley   +1 more source

Intrusion Detection Systems for the Internet of Drones Security Using Multi-Teacher Knowledge Distillation

IEEE Access
The Internet of Drones (IoD) is increasingly adopted in mission-critical applications, but it remains vulnerable to a wide range of cyberattacks due to its open communication channels and resource-constrained nodes.
Mostafa Ogab, Sofiane Zaidi, Abdelhabib Bourouis, Carlos T. Calafate   +3 more
doaj   +1 more source

Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA

Frontiers in Microbiology, 2019
Amino acid starvation in Escherichia coli activates the enzymatic activity of the stringent factor RelA, leading to accumulation of the alarmone nucleotide (p)ppGpp.
Kathryn Jane Turnbull, Kathryn Jane Turnbull, Kathryn Jane Turnbull, Ievgen Dzhygyr, Ievgen Dzhygyr, Søren Lindemose, Vasili Hauryliuk, Vasili Hauryliuk, Vasili Hauryliuk, Mohammad Roghanian, Mohammad Roghanian, Mohammad Roghanian   +11 more
doaj   +1 more source

Timing of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3‐Inflammasome Activation in Macrophages

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Utilizing a clinically relevant course of treatment, our study reveals that glucocorticoids protect against the late NLRP3 inflammasome activation regulating the IL‐1β secretion, the processing of GSDM‐D and pyroptosis following signal 2 stimulation. These potent anti‐inflammatory effects are mediated by the activation of GR signaling and the expansion
David Diaz‐Jimenez, Robert H. Oakley, Jackson A. Hoffman, Carl D. Bortner, Fred Lih, Jianying Li, Jason G. Williams, Erica Scappini, Kevin E. Gerrish, Stavros Garantziotis, Trevor K. Archer, John A. Cidlowski   +11 more
wiley   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions

Ecology and Evolution, Volume 16, Issue 2, February 2026.
Dormancy is presented as a conserved, reversible survival program in which epitranscriptomic RNA modifications are proposed to provide a rapid, energy‐efficient layer that establishes, maintains, and terminates the state by modulating mRNA stability, translation, and localization.
Ehsan Pashay Ahi
wiley   +1 more source