Results 91 to 100 of about 125,603 (234)

Case report and literature review: clinical manifestations and treatment of human RelA deficiency

Frontiers in Immunology
RelA deficiency resulting from mutations in the human RELA gene is a recently identified inborn errors of immunity (IEI). The RELA gene encodes the RelA (p65) protein, one of the five transcription factors of the NF-κB family, which plays a critical role
Chenghao Wang, Wenjie Wang, Xiaoying Hui, Jia Hou, Qinhua Zhou, Qifan Li, Qi Wu, Qi Ni, Bingbing Wu, Jinqiao Sun, Xiaochuan Wang, Xiaochuan Wang   +11 more
doaj   +1 more source

Tumor necrosis factor-alpha-dependent activation of a RelA homodimer in astrocytes. Increased phosphorylation of RelA and MAD-3 precede activation of RelA.

The Journal of biological chemistry, 1995
Rel proteins are important intracellular mediators of cytokine-induced signal transduction. To understand how cytokines affect different cell populations in the brain, we have characterized Rel activation in astrocytes. A RelA homodimer is uniquely activated in cytokine-stimulated astrocytes. Cytokine-dependent phosphorylation of the RelA inhibitor MAD-
J A, Diehl, W, Tong, G, Sun, M, Hannink
openaire   +1 more source

Women in business: Gender and commercial space in nineteenth‐century Glasgow

The Economic History Review, EarlyView.
Abstract Focusing on women entrepreneurs in a large British city, we examine how women's commercially listed businesses populated that city. Using commercial property rental records, our study allows us to understand sectoral variation and the distribution of businesses across the city and to assess both the absolute and relative contribution of women ...
Graeme Acheson, Gill Newton, Linda Perriton   +2 more
wiley   +1 more source

Actin networks modulate heterogeneous NF-κB dynamics in response to TNFα

eLife
The canonical NF-κB transcription factor RELA is a master regulator of immune and stress responses and is upregulated in pancreatic ductal adenocardinoma (PDAC) tumours.
Francesca Butera, Julia E Sero, Lucas G Dent, Chris Bakal   +3 more
doaj   +1 more source

The Myeloma Risk Variant of TNFRSF13B Shows Reduced NF‐κB Signalling Activity in HEK293 Cells

European Journal of Haematology, EarlyView.
ABSTRACT A single nucleotide variant rs34562254 in TNFRSF13B, which encodes TACI (transmembrane activator and CAML interactor), is associated with an increased risk of myeloma and MGUS. This variant encodes a proline to leucine substitution at residue 251 in the long isoform (P251L) and residue 205 in the short isoform (P205L) of TACI.
Richard Muyan Chen, Jackie L. Ludgate, Robert J. Weeks, Heather E. Cunliffe, Ali G. Dohan, Ian M. Morison   +5 more
wiley   +1 more source

The Impact of Multi-Agent Reorganization on Efficiency

Information
Multi-agent systems constitute a well-known paradigm to develop complex systems thanks to their ability to process dynamic situations. One of the mechanisms used to ensure dynamic responses is reorganization.
Abdelheq Silem, Zouheyr Tamrabet, Roumaissa Khanfar, Lina Tahir, Toufik Marir, Narimane Sahel, Varun Gupta   +6 more
doaj   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Circulating granulocyte colony‐stimulating factor as a sex‐unbiased global marker of lung and colorectal cancer cachexia pre‐clinical models

Experimental Physiology, EarlyView.
Abstract Cancer cachexia, affecting up to 80% of patients with advanced cancer, is characterized by metabolic and inflammatory dysregulation driven by tumour‐ and host‐derived factors. Although cytokines are central to cachexia pathogenesis, their circulating profiles and transcriptional relevance across models and sexes remain incompletely defined. We
Francielly Morena, Eleanor R. Schrems, Ana Regina Cabrera, Ruqaiza Muhyudin, Sepideh Shakeri, Stavroula Tsitkanou, Mark Viggars, Tyrone A. Washington, Nicholas P. Greene   +8 more
wiley   +1 more source

Extracellular high mobility group box 1 as a UV‐induced alarmin driving cutaneous inflammation and photoaging via TLR4 signaling

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
UV irradiation triggers the active release of HMGB1 from skin cell nuclei into the extracellular space. Extracellular HMGB1 binds TLR4 receptors on neighboring cells, initiating a signaling cascade that upregulates proinflammatory cytokines (IL‐1β, IL‐6, IL‐8, and TNF‐α). This chronic inflammatory state drives neutrophil infiltration and collagen fiber
Qian Liufu, Zhaoping Qin, Yan Yan, Yiru Xu, Tianyuan He, Yingchun Liu, Yaping Xiang, Chunfang Guo, Taihao Quan   +8 more
wiley   +1 more source