Results 161 to 170 of about 153,606 (275)

Enterococcus faecalis Extracellular Vesicles Deliver the Bacterial GTPase Obg to Hijack mTOR Signalling in Hepatocellular Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
E. faecalis is enriched in HCC tissue and can promote liver tumourigenesis by activating mTOR signalling pathway. Obg derived from E. faecalis extracellular vesicles (EVs) is a GTPase physically interacts with mTOR, and acts as an interkingdom activator of mTOR. EF‐Obg expression level in HCC tissue correlates with poor prognosis in HCC patients.
Ning Ma, Xiaoshan Xie, Jiarui Wang, Zhikai Zheng, Huilin Jin, Xijie Chen, Xiaoling Huang, Haidan Luo, Yue Wei, Qihao Pan, Boyu Zhang, Jiaying Zheng, Peng Zhang, Fenghai Yu, Xue Liu, Zhi‐Min Zhang, Zhongguo Zhou, Xiangqi Meng, Mong‐Hong Lee   +18 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Comprehensive metabolic characterization of pediatric ependymomas. [PDF]

Life Metab
Li T, Jin Y, Ren S, Liu Y, Cheng D, Bi Z, Li Y, Chen X, Zhu X, Chen Z, He W, Li Y, Liu Y, Luan G, Tian Y, Liu Y, Ge WP.   +16 more
europepmc   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

cJun-assisted loading of RelA DNA-binding promotes synergistic lung epithelial antimicrobial responses. [PDF]

iScience
Pantaleón García J, Bhoda K, Burch-Eapen M, Alonso Becerra R, Rodríguez Carstens P, Covarrubias López D, Foncerrada Lizaola J, Kulkarni VV, Martinez J, Wang Y, Evans SE.   +10 more
europepmc   +1 more source

RELA wt Allele [PDF]

, 2020
openaire   +1 more source

Phytochemicals in Asthma Management: Mechanism, Translational Gap and Clinical Integration

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
The phytochemicals including flavonoids, alkaloids, terpenoids, and saponins modulate inflammatory, oxidative, and immune pathways in asthma. It highlights their mechanisms of action, translational challenges, advanced formulation strategies, and emerging clinical potential as adjunct therapies for precision‐based asthma management.
Pulak Majumder, Trisita Majumder
wiley   +1 more source

Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer. [PDF]

Nat Commun
Su Y, Liu C, Lu X, Chuang HY, Li G, Shao S, Kong Y, Lee JW, Ng RH, Wong S, Robert L, Warden C, Liu V, Chen J, Wang Z, Qin G, Tang Y, Cheng H, Ng AHC, Chen D, Peng S, Xue M, Johnson D, Xu Y, Wang J, Wu X, Shmulevich I, Shi Q, Levine R, Ribas A, Baltimore D, Guo J, Heath JR, Wei W.   +33 more
europepmc   +1 more source

Precision environmental medicine: Integrated multi‐exposure transcriptomics for shared molecular networks in COPD pathogenesis in response to environmental exposure

Precision Medical Sciences, Volume 15, Issue 2, Page 147-159, June 2026.
This integrated systems biology study of 2847 exposure‐related genes identifies a conserved 647‐gene core and CYP1B1 hub across cigarette smoke, ozone, and PM2.5. Three key pathways converge, enabling computational repurposing of 15 drug candidates (e.g., NRF2 activators) for environmentally induced COPD.
Fakher Rahim, Gürler Akpinar, Kenesh Dzhusupov   +2 more
wiley   +1 more source

RELA Fusion Positive [PDF]

, 2020
openaire   +1 more source